Cultured human dermal fibroblasts do produce cortisol
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Cortisol and corticosterone production was detected in epidermal melanocytes and dermal fibroblasts, with chemical structure confirmed by LC/MS.
“We have also detected cortisol as well as corticosterone production in epidermal melanocytes and dermal fibroblasts (chemical structure was confirmed by LC/MS) [57, 58, 60].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [60]
In skin, induction of steroidogenesis by CRH, ACTH, or factors raising intracellular cAMP is cell type dependent: corticosterone and cortisol formation is induced in normal and malignant epidermal melanocytes and dermal fibroblasts, but not in epidermal keratinocytes.
“In the skin, induction of steroidogenesis by CRH or ACTH, or factors raising intracellular cAMP levels appears to be cell type dependent because induced corticosterone and cortisol formation has been observed in normal and malignant epidermal melanocytes [53, 58] and dermal fibroblasts [57, 60], but not epidermal keratinocytes.”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [60]
Cites
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727 · see citing works
Self-citationIto, N., Ito, T., Kromminga, A., Bettermann, A., Takigawa, M., Kees, F., Straub, R. H., & Paus, R. (2005) · The FASEB Journal · doi:10.1096/fj.04-1968fje · Cited by 498 · see citing works
Cutaneous androgen metabolism: basic research and clinical perspectives
Chen, W., Thiboutot, D., & Zouboulis, C. C. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.00613.x · Cited by 273 · see citing works
Slominski, A., Zjawiony, J., Wortsman, J., Semak, I., Stewart, J., Pisarchik, A., Sweatman, T., Marcos, J., Dunbar, C., & C. Tuckey, R. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04356.x · Cited by 243 · see citing works
Self-citationACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.
Slominski, A., Ermak, G., & Mihm, M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.7.8675607 · Cited by 216 · see citing works
Self-citationCRH stimulation of corticosteroids production in melanocytes is mediated by ACTH
Slominski, A., Zbytek, B., Szczesniewski, A., Semak, I., Kaminski, J., Sweatman, T., & Wortsman, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00519.2004 · Cited by 211 · see citing works
Self-citationAndrogen action on human skin – from basic research to clinical significance
Zouboulis, C. C., & Degitz, K. (2004) · Experimental Dermatology · doi:10.1111/j.1600-0625.2004.00255.x · Cited by 183 · see citing works
CRH stimulates POMC activity and corticosterone production in dermal fibroblasts
Slominski, A., Zbytek, B., Semak, I., Sweatman, T., & Wortsman, J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.014 · Cited by 143 · see citing works
Neuroendocrine System of the Skin
Slominski, A. T. (2005) · Dermatology · doi:10.1159/000087012 · Cited by 138 · see citing works
Self-citationActive steroidogenesis in the normal rat skin
Slominski, A. T. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00215-9 · Cited by 63 · see citing works
Self-citationMetabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells
Slominski, A., Gomez-Sanchez, C. E., Foecking, M. F., & Wortsman, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00889-3 · Cited by 60 · see citing works
Self-citationSteroidogenesis in the human skin: 21-hydroxylation in cultured keratinocytes
Rogoff, D., Gómez-Sánchez, C. E., Foecking, M. F., Wortsman, J., & Slominski, A. T. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00076-0 · Cited by 33 · see citing works
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Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works
Key role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works
Self-citationSteroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Self-citationTaves, M. D., Gomez-Sanchez, C. E., & Soma, K. K. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2011 · Cited by 293 · see citing works
Differential expression of HPA axis homolog in the skin
Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.012 · Cited by 279 · see citing works
Self-citationCutaneous hypothalamic–pituitary–adrenal axis homolog: regulation by ultraviolet radiation
Skobowiat, C., Dowdy, J. C., Sayre, R. M., Tuckey, R. C., & Slominski, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00217.2011 · Cited by 269 · see citing works
Self-citationCortisol synthesis in epidermis is induced by IL-1 and tissue injury
Vukelic, S., Stojadinovic, O., Pastar, I., Rabach, M., Krzyzanowska, A., Lebrun, E., Davis, S. C., Resnik, S., Brem, H., & Tomic-Canic, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188268 · Cited by 193 · see citing works
UVB activates hypothalamic-pituitary-adrenal axis in C57BL/6 mice
Skobowiat, C., & Slominski, A. T. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.450 · Cited by 126 · see citing works
Self-citationSkin as an endocrine organ: implications for its function
Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.04.004 · Cited by 116 · see citing works
Self-citationSteroid synthesis by primary human keratinocytes; implications for skin disease
Hannen, R. F., Michael, A. E., Jaulim, A., Bhogal, R., Burrin, J. M., & Philpott, M. P. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.059 · Cited by 96 · see citing works
Stress-linked cortisol concentrations in hair: what we know and what we need to know
Sharpley, C. F., McFarlane, J. R., & Slominski, A. (2012) · revneuro · doi:10.1515/rns.2011.058 · Cited by 92 · see citing works
Self-citationSlominski, A. T., Zmijewski, M. A., Semak, I., Sweatman, T., Janjetovic, Z., Li, W., Zjawiony, J. K., & Tuckey, R. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004309 · Cited by 90 · see citing works
Self-citationCutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity
Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology · doi:10.1111/exd.12376 · Cited by 79 · see citing works
Skin steroidogenesis in health and disease
Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76 · see citing works
Self-citation
- Authors
- Slominski, A., Zbytek, B., Szczesniewski, A., & Wortsman, J.
- Affiliations
- University of Tennessee Health Science Center (US)
- Agilent Technologies (United States) (US)
- SIU Medicine (US)
- Corresponding author
- Slominski, Andrzej
- ORCID
- Slominski, Andrzej
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 126
- Issue
- 5
- Pages
- 1177-1178
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC1472636
- OpenAlex
- W1983575165
- Cited by
- 66
- References
- 12
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR047079)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- cortisol production, dermal fibroblasts, CYP11A1, CYP17, CYP21A2, ACTH receptor, steroidogenic enzymes, androgen metabolism, estrogen metabolism, CYP19A1, aromatase
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Fibroblasts, Humans, Hydrocortisone, Progesterone, Skin, 1-Methyl-3-isobutylxanthine
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