Corticotropin releasing hormone and the skin
Open accessAbstract
Cotricotropin-releasing hormone (CRH) and related peptides are produced in skin that is dependent on species and anatomical location. Local peptide production is regulated by ultraviolet radiation (UVR), glucocorticoids and phase of the hair cycle. The skin also expresses the corresponding receptors (CRH-R1 and CRH-R2), with CRH-R1 being the major receptor in humans. CRH-R1 is expressed in epidermal and dermal compartments, and CRH-R2 predominantly in dermal structures. The gene coding for CRH-R1 generates multiple isoforms through a process modulated by UVR, cyclic adenosine monophosphate (cAMP) and phorbol 12-myristate 13-acetate. The phenotypic effects of CRH in human skin cells are largely mediated by CRH-R1alpha through increases in concentrations of cAMP, inositol triphosphate (IP3), or Ca2+ with subsequent activation of protein kinases A (PKA) and C (PKC) dependent pathways. CRH also modulates the activity of nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-kappaB), activator protein 1 (AP-1) and cAMP responsive element binding protein (CREB). The cellular functions affected by CRH depend on cell type and nutritional status and include modulation of differentiation program(s), proliferation, viability and immune activity. The accumulated evidence indicates that cutaneous CRH is also a component of a local structure organized similarly to the hypothalamo-pituitary-adrenal axis.
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Mammalian skin expresses all regulatory elements of the HPA axis, including POMC-derived peptides, CRH and related peptides, and their functional receptors.
“Since all regulatory elements of the hypothalamus-pituitary-adrenal gland (HPA) axis, including proopiomelanocortin (POMC)-derived peptides [129], CRH and related peptides as well as the corresponding functional receptors [130, 131] are expressed in mammalian skin, the concept that skin expresses a homologue of the HPA was introduced 15 years ago [2, 73, 132].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [131]
Mammalian skin expresses all regulatory elements of the HPA axis, including POMC-derived peptides, CRH and related peptides, and their functional receptors.
“Since all regulatory elements of the hypothalamus-pituitary-adrenal gland (HPA) axis, including proopiomelanocortin (POMC)-derived peptides [129], CRH and related peptides as well as the corresponding functional receptors [130, 131] are expressed in mammalian skin, the concept that skin expresses a homologue of the HPA was introduced 15 years ago [2, 73, 132].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [130]
UVB has a similar stimulatory effect on CRH and POMC signaling, production of cortisol, and inhibition of the GR.
“UVB (280–320 nm), a recognized stimulator of melanin pigmentation [152], has similar stimulatory effect on CRH and POMC signaling, production of cortisol and inhibition of the GR [81, 129, 131, 151, 153, 154].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [131]
The CRH signaling system is highly expressed in mammalian skin (epidermis and dermis), and its expression is upregulated by UVR.
“The CRH signaling system is highly expressed in mammalian skin (epidermis and dermis), and its expression is up-regulated by UVR [1, 131].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [131]
Higher elements of the HPA axis are functional within the pilosebaceous unit and help maintain its immune privilege.
“The higher elements of the HPA axis are functional within the pilosebaceous unit and provide another important element maintaining the immune privilege of this site [131, 133, 171, 183].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [131]
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Perrin, M. H., DiGruccio, M. R., Koerber, S. C., Rivier, J., Kunitake, K. S., Bain, D. L., Fischer, W. H., & Vale, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210476200 · Cited by 57 · see citing works
Inhibition of mouse melanoma cell proliferation by corticotropin-releasing hormone and its analogs.
Carlson, K. W., Nawy, S. S., Wei, E. T., Sadée, W., Filov, V. A., Rezsova, V. V., Slominski, A. T., & Quillan, J. M. (2001) · PubMed · Cited by 57 · see citing works
Self-citationCorticotropin-Releasing Hormone Stimulates Angiogenesis and Epithelial Tumor Growth in the Skin
Arbiser, J. L., Karalis, K. P., Viswanathan, A. N., Koike, C., Anand‐Apte, B., Flynn, E. A., Zetter, B. R., & Majzoub, J. A. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00760.x · Cited by 56 · see citing works
The Genomic Structure of the Rat Corticotropin Releasing Factor Receptor
Tsai‐Morris, C., Buczko, E. S., Geng, Y., Gamboa-Pinto, A., & Dufau, M. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14519 · Cited by 55 · see citing works
Effect of CRF and related peptides on calcium signaling in human and rodent melanoma cells
Fazal, N., Slominski, A. T., Choudhry, M. A., Wei, E. T., & Sayeed, M. M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01067-9 · Cited by 53 · see citing works
Self-citationHagan, P., Poole, S., & Bristow, A. F. (1992) · Biochemical Journal · doi:10.1042/bj2810251 · Cited by 52 · see citing works
Seck, T. L., Baron, R., & Horne, W. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211280200 · Cited by 51 · see citing works
Slominski, A. T. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.10.3582 · Cited by 49 · see citing works
Self-citationWiesner, B., Roloff, B., Fechner, K., & Slominski, A. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00301 · Cited by 48 · see citing works
Self-citationPapadopoulou, N., Chen, J., Randeva, H. S., Levine, M. A., Hillhouse, E. W., & Grammatopoulos, D. K. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0365 · Cited by 47 · see citing works
Corticotropin-releasing hormone triggers differentiation in HaCaT keratinocytes
Zbytek, B., Pikuła, M., Slominski, R. M., Myśliwski, A., Wei, E. T., Wortsman, J., & Slominski, A. T. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06217.x · Cited by 46 · see citing works
Self-citationBenou, C., Wang, Y., Imitola, J., VanVlerken, L., Chandras, C., Karalis, K. P., & Khoury, S. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5407 · Cited by 46 · see citing works
Kondo, S., & Jimbow, K. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199812)177:3 · Cited by 44 · see citing works
Wietfeld, D., Heinrich, N., Furkert, J., Fechner, K., Beyermann, M., Bienert, M., & Berger, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405335200 · Cited by 44 · see citing works
Regulation of Nuclear Factor-κB by Corticotropin-Releasing Hormone in Mouse Thymocytes
Zhao, J., & Karalis, K. P. (2002) · Molecular Endocrinology · doi:10.1210/me.2001-0334 · Cited by 44 · see citing works
Myers, D. A., Trinh, J. V., & Myers, T. R. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00157-9 · Cited by 40 · see citing works
Pisarchik, A. V., & Slominski, A. T. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01770.x · Cited by 39 · see citing works
Self-citationCorticotropin-Releasing Hormone Inhibits Nuclear Factor-κB Pathway in Human HaCaT Keratinocytes
Pfeffer, L. M., Slominski, A. T., & Zbytek, B. (2003) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2003.12612.x · Cited by 35 · see citing works
Self-citationTjuvajev, J., Kolesnikov, Y. A., Joshi, R., Sherinski, J., Koutcher, L. D., Zhou, Y., Matei, C., Koutcher, J. A., Kreek, M. J., & Blasberg, R. (1998) · PubMed · Cited by 34 · see citing works
Urocortin and Inflammation: Confounding Effects of Hypotension on Measures of Inflammation
Torpy, D. J., Webster, E. L., Zachman, E. K., Aguilera, G., & Chrousos, G. P. (1999) · NeuroImmunoModulation · doi:10.1159/000026380 · Cited by 34 · see citing works
Microvascular Effects of CRH in Human Skin Vary in Relation to Gender
Clifton, V. L., Crompton, R., Smith, R., & Wright, I. M. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8149 · Cited by 32 · see citing works
Wei, E. T., Thomas, H. A., Christian, H., Buckingham, J. C., & Kishimoto, T. (1998) · Peptides · doi:10.1016/s0196-9781(98)00085-0 · Cited by 28 · see citing works
Ständer, S., Böhm, M., Brzoska, T., Zimmer, K., Luger, T. A., & Metze, D. (2002) · Experimental Dermatology · doi:10.1034/j.1600-0625.2002.110105.x · Cited by 27 · see citing works
Ugele, B., & Lange, F. (2001) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1290/1071-2690(2001)037 · Cited by 24 · see citing works
Self-citationGjerde, E.-A. B., Woie, K., Wei, E. T., & Reed, R. K. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00403-8 · Cited by 20 · see citing works
Wei, E. T., & Thomas, H. A. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90729-3 · Cited by 17 · see citing works
Pereda, M. P. (1995) · Endocrinology · doi:10.1210/en.136.12.5504 · Cited by 17 · see citing works
Clifton, V. L., Crompton, R., Read, M. A., Gibson, P. G., Smith, R., & Wright, I. M. R. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06030 · Cited by 15 · see citing works
The skin as a model for the immunodulatory effects of corticotropin-releasing hormone
Slominski, A. T., Wortsman, J., Linton, E. A., Pisarchik, A. V., & Zbytek, B. (2003) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8039-8_10 · Cited by 14 · see citing works
Self-citation河野, 美. (2003) · Medical Entomology and Zoology · Cited by 13 · see citing works
Mind over Matter - Regulation of Peripheral Inflammation by the CNS
(2003) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8039-8 · Cited by 11 · see citing works
AGED GARLIC EXTRACT SUPPRESSES LIPID PEROXIDATION INDUCED BY β-AMYLOID IN PC12 CELLS
Griffin, B., Selassie, M., & Gwebu, E. T. (2000) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1290/1071-2690(2000)036 · Cited by 8 · see citing works
Self-citationPharmacology and Biology of Corticotropin-Releasing Factor (CRF) Receptors
Eckart, K., Jahn, O., Radulović, J., et al. (2002) · Receptors and Channels · doi:10.3109/10606820213678 · Cited by 8 · see citing works
Tobin, D. J. (2003) · CRC Press eBooks · doi:10.4324/9780203912867-21 · Cited by 1 · see citing works
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- Kauser, S., A. Slominski, E. Wei & D. J. Tobin: Corticotropin-releasing hormone and related peptides stimulate follicular melanocyte behaviour in vitro and also modulate human hair fibre elongation in organ culture. Journal of the German Society of Dermatology, 6, 494 (2004) 103.
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Slominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., & Steketee, J. D. (2012) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-19683-6 · Cited by 502 · see citing works
Self-citationSlominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works
How UV Light Touches the Brain and Endocrine System Through Skin, and Why
Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P., & Paus, R. (2018) · Endocrinology · doi:10.1210/en.2017-03230 · Cited by 452 · see citing works
Self-citationKey role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works
Self-citationSteroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Self-citationRegulation of melanogenesis – controversies and new concepts
Schallreuter, K. U., Kothari, S., Chavan, B., & Spencer, J. D. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00675.x · Cited by 352 · see citing works
Differential expression of HPA axis homolog in the skin
Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.012 · Cited by 279 · see citing works
Self-citationCutaneous hypothalamic–pituitary–adrenal axis homolog: regulation by ultraviolet radiation
Skobowiat, C., Dowdy, J. C., Sayre, R. M., Tuckey, R. C., & Slominski, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00217.2011 · Cited by 269 · see citing works
Self-citationThe human hair: from anatomy to physiology
Buffoli, B., Rinaldi, F., Labanca, M., Sorbellini, E., Trink, A., Guanziroli, E., Rezzani, R., & Rodella, L. F. (2013) · International Journal of Dermatology · doi:10.1111/ijd.12362 · Cited by 268 · see citing works
POMC: The Physiological Power of Hormone Processing
Harno, E., Ramamoorthy, T. G., Coll, A. P., & White, A. E. (2018) · Physiological Reviews · doi:10.1152/physrev.00024.2017 · Cited by 265 · see citing works
The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.
Deussing, J., & Chen, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2017 · Cited by 234 · see citing works
Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation
Serre, C., Busuttil, V., & Botto, J.-M. (2018) · International Journal of Cosmetic Science · doi:10.1111/ics.12466 · Cited by 255 · see citing works
Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: Ancient CRF paralogs
Fekete, É. M., & Zorrilla, E. P. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.09.002 · Cited by 244 · see citing works
Aberg, K. M., Radek, K. A., Choi, E., Kim, D.-K., Demerjian, M., Hupe, M., Kerbleski, J. F., Gallo, R. L., Ganz, T., Mauro, T. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31726 · Cited by 234 · see citing works
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides
Slominski, A. T., Slominski, R. M., Raman, C., Chen, J. Y., Athar, M., & Elmets, C. A. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00147.2022 · Cited by 195 · see citing works
Self-citationCortisol synthesis in epidermis is induced by IL-1 and tissue injury
Vukelic, S., Stojadinovic, O., Pastar, I., Rabach, M., Krzyzanowska, A., Lebrun, E., Davis, S. C., Resnik, S., Brem, H., & Tomic-Canic, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188268 · Cited by 193 · see citing works
Rousseau, K., Kauser, S., Pritchard, L. E., Warhurst, A., Oliver, R. L., Slominski, A. T., Wei, E. T., Thody, A. J., Tobin, D. J., & White, A. E. (2007) · The FASEB Journal · doi:10.1096/fj.06-7398com · Cited by 178 · see citing works
Self-citationMelatonin and the hair follicle
Fischer, T. W., Slominski, A. T., Tobin, D. J., & Paus, R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00512.x · Cited by 168 · see citing works
Self-citationThe Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects
Marek‐Józefowicz, L., Czajkowski, R., Borkowska, A., Nedoszytko, B., Zmijewski, M. A., Cubała, W. J., & Slominski, A. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020669 · Cited by 161 · see citing works
Self-citationExtra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders
Slominski, R. M., Tuckey, R. C., Manna, P. R., Jetten, A. M., Postlethwaite, A., Raman, C., & Slominski, A. T. (2020) · Genes & Immunity · doi:10.1038/s41435-020-0096-6 · Cited by 155 · see citing works
Self-citationPerinatal stress, brain inflammation and risk of autism-Review and proposal
Angelidou, A., Asadi, S., Alysandratos, K., Karagkouni, A., Kourembanas, S., & Theoharides, T. C. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-89 · Cited by 153 · see citing works
Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris
Gancevičienė, R., Gražienë, V., Fimmel, S., & Zouboulis, C. C. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08959.x · Cited by 146 · see citing works
Cutaneous innervation in impaired diabetic wound healing
Nowak, N. C., Menichella, D. M., Miller, R., & Paller, A. S. (2021) · Translational research · doi:10.1016/j.trsl.2021.05.003 · Cited by 144 · see citing works
From the Brain-Skin Connection: The Neuroendocrine-Immune Misalliance of Stress and Itch
Arck, P., & Paus, R. (2006) · NeuroImmunoModulation · doi:10.1159/000104863 · Cited by 135 · see citing works
Neuro–immuno–endocrinology of the skin: how environment regulates body homeostasis
Slominski, R. M., Raman, C., Jetten, A. M., & Slominski, A. T. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01107-x · Cited by 133 · see citing works
Self-citationAssociation between Stress and the HPA Axis in the Atopic Dermatitis
Lin, T.-K., Zhong, L., & Santiago, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102131 · Cited by 127 · see citing works
“It has been reported that all r gulatory el ments of th c tral HPA axis were express d in mammalian skin, including CRH, POMC-derived peptid s, GCs [36,53], and related peptides, as well their appropriate functional receptors, CRH receptors, melan cortin receptor type 2 (MCR2, the classical adrenocortical ACTH recepto…”
BackgroundUVB activates hypothalamic-pituitary-adrenal axis in C57BL/6 mice
Skobowiat, C., & Slominski, A. T. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.450 · Cited by 126 · see citing works
Self-citationNeuroendocrine activity of the melanocyte
Slominski, A. T. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00892.x · Cited by 125 · see citing works
Self-citationNeuroendocrinology and neurobiology of sebaceous glands
Clayton, R. W., Langan, E. A., Ansell, D. M., de Vos, I. J. H. M., Göbel, K., Schneider, M. R., Picardo, M., Lim, X., Steensel, M. A. M. V., & Paus, R. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12579 · Cited by 123 · see citing works
Neuroendocrinology of mast cells: Challenges and controversies
Theoharides, T. C. (2017) · Experimental Dermatology · doi:10.1111/exd.13288 · Cited by 117 · see citing works
Skin as an endocrine organ: implications for its function
Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.04.004 · Cited by 116 · see citing works
Self-citationProlactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone
Foitzik, K., Langan, E. A., & Paus, R. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.348 · Cited by 116 · see citing works
The Melanocyte and the Epidermal Melanin Unit: An Expanded Concept
Nordlund, J. J. (2007) · Dermatologic Clinics · doi:10.1016/j.det.2007.04.001 · Cited by 109 · see citing works
Alexopoulos, A., & Chrousos, G. P. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9367-y · Cited by 109 · see citing works
Zhang, G., Ren, Y., Sheng, L.-X., Chi, Y., Du, W., Guo, S., Jiang, Z.-N., Xiao, L., Luo, X.-N., Tang, Y., et al. (2008) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990802385781 · Cited by 105 · see citing works
Leptin and the skin: a new frontier
Pöeggeler, B., Schulz, C., Pappolla, M. A., Bodó, E., Tiede, S., Lehnert, H., & Paus, R. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00930.x · Cited by 102 · see citing works
Almasi, B., Roulin, A., Jenni‐Eiermann, S., & Jenni, L. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.02.021 · Cited by 101 · see citing works
Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Brożyna, A. A., Granese, J., Pisarchik, A. V., Szczesniewski, A., & Tobin, D. J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.376 · Cited by 98 · see citing works
Self-citationThe significance of CYP11A1 expression in skin physiology and pathology
Slominski, R. M., Raman, C., Elmets, C. A., Jetten, A. M., Slominski, A. T., & Tuckey, R. C. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111238 · Cited by 97 · see citing works
Self-citationRole of TRPM in melanocytes and melanoma
Guo, H., Carlson, J. A., & Slominski, A. T. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01565.x · Cited by 97 · see citing works
Self-citationA nervous breakdown in the skin: stress and the epidermal barrier
Slominski, A. T. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33508 · Cited by 96 · see citing works
Self-citationWhat are subcutaneous adipocytes really good for…?
Paus, R., Klein, J. C., Permana, P. A., Owecki, M., Chaldakov, G. N., Böhm, M., Hausman, G., Lapiere, C. M., Atanassova, P. K., Sowiński, J., et al. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00519_1.x · Cited by 94 · see citing works
Self-citationStress-linked cortisol concentrations in hair: what we know and what we need to know
Sharpley, C. F., McFarlane, J. R., & Slominski, A. (2012) · revneuro · doi:10.1515/rns.2011.058 · Cited by 92 · see citing works
Self-citationCytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
Slominski, A. T., Zmijewski, M. A., Semak, I. V., Zbytek, B., Pisarchik, A. V., Li, W., Zjawiony, J. K., & Tuckey, R. C. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990308 · Cited by 91 · see citing works
Self-citationUpadhyay, P. R., Ho, T., & ABDEL‐MALEK, Z. A. (2021) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12985 · Cited by 91 · see citing works
Zhang, X., Yu, M., Yu, W. K., Weinberg, J., Shapiro, J., & McElwee, K. J. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.371 · Cited by 90 · see citing works
Logesh, R., Prasad, S. R., Chipurupalli, S., Robinson, N., & Mohankumar, S. K. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188968 · Cited by 89 · see citing works
Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy
Brożyna, A. A., Slominski, R. M., Nedoszytko, B., Zmijewski, M. A., & Slominski, A. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158575 · Cited by 84 · see citing works
Self-citationCholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells
Schallreuter, K. U., Hasse, S., Rokos, H., Chavan, B., Shalbaf, M., Spencer, J. D., & Wood, J. M. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00850.x · Cited by 82 · see citing works
Melanocyte Receptors: Clinical Implications and Therapeutic Relevance
Carlson, J. A., Linette, G. P., Aplin, A. E., Ng, B., & Slominski, A. T. (2007) · Dermatologic Clinics · doi:10.1016/j.det.2007.06.005 · Cited by 75 · see citing works
Self-citationProfiling the Response of Human Hair Follicles to Ultraviolet Radiation
Lu, Z., Fischer, T. W., Hasse, S., Sugawara, K., Kamenisch, Y., Krengel, S., Funk, W., Berneburg, M., & Paus, R. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.418 · Cited by 75 · see citing works
Slominski, A. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08958.x · Cited by 74 · see citing works
Self-citationNeuroendocrinology of the skin
Zmijewski, M. A., & Slominski, A. T. (2011) · Dermato-Endocrinology · doi:10.4161/derm.3.1.14617 · Cited by 73 · see citing works
Self-citationRizzi, V., Gubitosa, J., Fini, P., & Cosma, P. (2021) · Cosmetics · doi:10.3390/cosmetics8030066 · Cited by 70 · see citing works
Prolactin—a novel neuroendocrine regulator of human keratin expression in situ
Ramot, Y., Bir, T., Tiede, S., ́th, B. ́. I. T., Langan, E. A., Sugawara, K., Foitzik, K., Ingber, A., Goffin, V., Langbein, L., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-146415 · Cited by 69 · see citing works
Samotij, D., Nedoszytko, B., Bartosińska, J., Batycka-Baran, A., Czajkowski, R., Dobrucki, I. T., Dobrucki, L. W., Górecka-Sokołowska, M., Janaszak‐Jasiecka, A., Krasowska, D., et al. (2020) · Advances in Dermatology and Allergology · doi:10.5114/ada.2020.94832 · Cited by 68 · see citing works
Self-citationContribution of stress to asthma worsening through mast cell activation
Theoharides, T. C., Enakuaa, S., Sismanopoulos, N., Asadi, S., Papadimas, E. C., Angelidou, A., & Alysandratos, K. (2012) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2012.03.003 · Cited by 68 · see citing works
Immunomodulatory Effects of Sex Hormones: Requirements for Pregnancy and Relevance in Melanoma
Enninga, E. A. L., Holtan, S. G., Creedon, D. J., Dronca, R. S., Nevala, W. K., Ognjanovic, S., & Markovic, S. N. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.01.006 · Cited by 64 · see citing works
Emerging role of alternative splicing of CRF1 receptor in CRF signaling.
Zmijewski, M. A., & Slominski, A. T. (2010) · Acta Biochimica Polonica · doi:10.18388/abp.2010_2366 · Cited by 64 · see citing works
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- Authors
- Slominski, A.
- Affiliations
- University of Tennessee Health Science Center (US)
- Corresponding author
- Slominski, Andrzej
- ORCID
- Slominski, Andrzej
- Venue
- Frontiers in bioscience
- Publisher
- IMR Press
- Published
- 2006
- Volume
- 11
- Issue
- 1
- Pages
- 2230
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/1966
- PMC
- PMC1847336
- OpenAlex
- W2002289379
- Cited by
- 157
- References
- 121
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 11 · 2012: 8
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (1R01-AR047079, R01AR047079)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- corticotropin-releasing factor, skin, CRH receptors, ultraviolet radiation, glucocorticoids, hair cycle, cAMP signaling, NF-κB, AP-1, CREB, skin cell proliferation, skin immunity, hypothalamic-pituitary-adrenal axis
- MeSH terms
- CRF Receptor, Type 1, Corticotropin-Releasing Hormone, Humans, Hypothalamo-Hypophyseal System, Peptides, Phenotype, Pituitary-Adrenal System, Skin, Skin Physiological Phenomena, Skin Pigmentation, Ultraviolet Rays, Second Messenger Systems, Signal Transduction, Alternative Splicing, Receptors, Corticotropin-Releasing Hormone, Hair Follicle, Cell Culture Techniques, Protein Isoforms, Urocortins
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