Cited by 46Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes Management and Research

First-phase insulin secretion: can its evaluation direct therapeutic approaches?

Open access
Di Giuseppe, Gianfranco, Ciccarelli, Gea, Soldovieri, Laura, Capece, Umberto, Cefalo, Chiara M.A., Moffa, Simona, Nista, Enrico C., Brunetti, Michela +5 more·2023·Trends in Endocrinology & Metabolism

Abstract

Our work is aimed at unraveling the role of the first-phase insulin secretion in the natural history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance and with β cell function and mass. Starting from pathophysiology, we investigate the impact of impaired secretion on glucose homeostasis and explore postmeal hyperglycemia as the main clinical feature, underlining its relevance in the management of the disease. We also review dietary and pharmacological approaches aimed at improving early secretory defects and restoring residual β cell function. Furthermore, we discuss possible approaches to detect early secretory defects in clinical practice. By providing a journey through human and animal data, we attempt a unification of the recent evidence in an effort to offer a new outlook on β cell secretion.

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Authors
Di Giuseppe, G., Ciccarelli, G., Soldovieri, L., Capece, U., Cefalo, C. M. A., Moffa, S., Nista, E. C., Brunetti, M., Cinti, F., Gasbarrini, A., Pontecorvi, A., Giaccari, A., & Mezza, T.
Affiliations
Università Cattolica del Sacro Cuore (IT)
Corresponding author
Giaccari, Andrea
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2023-04
Volume
34
Issue
4
Pages
216-230
ISSN
1043-2760 (ISSN-L)
OpenAlex
W4322489591
Cited by
46
References
151
Citations by year
2026: 18 · 2025: 14 · 2024: 10 · 2023: 4
FWCI
2.98
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • European Foundation for the Study of Diabetes (D.3.2)
  • Ministero dell’Istruzione, dell’Università e della Ricerca (RF-2019-12369293, GR-2018-12365577, PRIN 2020SH2ZZA)
  • Università Cattolica del Sacro Cuore (Linea D.1, D.3.2)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
first-phase insulin secretion, type 2 diabetes, insulin resistance, beta-cell function, beta-cell mass, glucose homeostasis, postprandial hyperglycemia, dietary intervention, pharmacotherapy, beta-cell secretion
MeSH terms
Insulin Secretion, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Humans, Insulin, Insulin Resistance, Insulin-Secreting Cells

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