First-phase insulin secretion: can its evaluation direct therapeutic approaches?
Open accessAbstract
Our work is aimed at unraveling the role of the first-phase insulin secretion in the natural history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance and with β cell function and mass. Starting from pathophysiology, we investigate the impact of impaired secretion on glucose homeostasis and explore postmeal hyperglycemia as the main clinical feature, underlining its relevance in the management of the disease. We also review dietary and pharmacological approaches aimed at improving early secretory defects and restoring residual β cell function. Furthermore, we discuss possible approaches to detect early secretory defects in clinical practice. By providing a journey through human and animal data, we attempt a unification of the recent evidence in an effort to offer a new outlook on β cell secretion.
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Loss of first-phase insulin secretion is an early hallmark of individuals with diabetes or impaired glucose tolerance, despite an enhancement of second-phase insulin secretion.
“Loss of first-phase insulin secretion is an early hallmark of individuals with diabetes or impaired glucose tolerance, despite an enhancement of second-phase insulin secretion (30).”
From Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With <i>MTNR1B</i> Diabetes Risk Variant (2026) · cites this paper as [30]
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Self-citationTirzépatide, sensibilité et sécrétion d’insuline
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Deletion of RalGAP β protects pancreatic β cells and improves glycemic control
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- Authors
- Di Giuseppe, G., Ciccarelli, G., Soldovieri, L., Capece, U., Cefalo, C. M. A., Moffa, S., Nista, E. C., Brunetti, M., Cinti, F., Gasbarrini, A., Pontecorvi, A., Giaccari, A., & Mezza, T.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Giaccari, Andrea
- ORCID
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 34
- Issue
- 4
- Pages
- 216-230
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W4322489591
- Cited by
- 46
- References
- 151
- Citations by year
- 2026: 18 · 2025: 14 · 2024: 10 · 2023: 4
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- European Foundation for the Study of Diabetes (D.3.2)
- Ministero dell’Istruzione, dell’Università e della Ricerca (RF-2019-12369293, GR-2018-12365577, PRIN 2020SH2ZZA)
- Università Cattolica del Sacro Cuore (Linea D.1, D.3.2)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- first-phase insulin secretion, type 2 diabetes, insulin resistance, beta-cell function, beta-cell mass, glucose homeostasis, postprandial hyperglycemia, dietary intervention, pharmacotherapy, beta-cell secretion
- MeSH terms
- Insulin Secretion, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Humans, Insulin, Insulin Resistance, Insulin-Secreting Cells
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