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Cited by 194

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Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

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Yamashita, H., Ichijo, H., Grimsby, S., Morén, A., ten Dijke, P., Miyazono, K.·1994·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)42126-0
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Abstract

Human endoglin is a dimeric protein that binds transforming growth factor-beta (TGF-beta). A porcine cDNA clone for endoglin was obtained from a porcine uterus cDNA library. The deduced sequence of the primary translated product of endoglin consists of 643 amino acids with a high sequence identity (96%) to human endoglin in the transmembrane and intracellular domains, but with a lower sequence similarity (66%) in the extracellular domain. In contrast to human endoglin, porcine endoglin has no Arg-Gly-Asp tripeptide in its sequence. Antibodies, raised against a peptide corresponding to the intracellular domain of porcine endoglin, immunoprecipitated an 84-kDa protein under reducing condition and a 130-kDa protein under nonreducing condition in porcine aortic endothelial cells. Porcine endoglin bound TGF-beta 1 and -beta 3 efficiently, but TGF-beta 2 less efficiently. Endoglin was found to be coimmunoprecipitated with TGF-beta receptors type I and/or II by the endoglin antibodies or by TGF-beta receptor II antibodies in the presence of ligand. Thus, endoglin and TGF-beta receptors I and/or II most likely formed a heteromeric receptor complex. Endoglin was phosphorylated on serine residue(s), which did not change after stimulation by TGF-beta 1. These results revealed that endoglin is a phosphorylated protein which forms a heteromeric complex with signaling receptors for TGF-beta.

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Metadata

Authors
Yamashita, H., Ichijo, H., Grimsby, S., Morén, A., ten Dijke, P., & Miyazono, K.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1994-01
Volume
269
Issue
3
Pages
1995-2001
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(17)42126-0
OpenAlex
W1568363145
Cited by
194
References
1
FWCI
4.41
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta. https://app.cochat.ai/papers/10.1016/s0021-9258(17)42126-0
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Yamashita, H., Ichijo, H., Grimsby, S., Morén, A., ten Dijke, P., & Miyazono, K. (1994). Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)42126-0

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