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Cited by 535

The DOI matches its Crossref record.

Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo

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Dyer, D.G., Blackledge, J.A., Thorpe, S.R., Baynes, J.W.·1991·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)99007-1
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Abstract

A fluorescent compound has been detected in proteins browned during Maillard reactions with glucose in vitro and shown to be identical to pentosidine, a pentose-derived fluorescent cross-link formed between arginine and lysine residues in collagen (Sell, D. R., and Monnier, V. M. (1989) J. Biol. Chem. 264, 21597-21602). Pentosidine was the major fluorophore formed during nonenzymatic browning of ribonuclease and lysozyme by glucose, but accounted for less than 1% of non-disulfide cross-links in protein dimers formed during the reaction. Pentosidine was formed in greatest yields in reactions of pentoses with lysine and arginine in model systems but was also formed from glucose, fructose, ascorbate, Amadori compounds, 3-deoxyglucosone, and other sugars. Pentosidine was not formed from peroxidized polyunsaturated fatty acids or malondialdehyde. Its formation from carbohydrates was inhibited under nitrogen or anaerobic conditions and by aminoguanidine, an inhibitor of advanced glycation and browning reactions. Pentosidine was detected in human lens proteins, where its concentration increased gradually with age, but it did not exceed trace concentrations (less than or equal to 5 mumol/mol lysine), even in the 80-year-old lens. Although its precise carbohydrate source in vivo is uncertain and it is present in only trace concentrations in tissue proteins, pentosidine appears to be a useful biomarker for assessing cumulative damage to proteins by nonenzymatic browning reactions with carbohydrates.

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Metadata

Authors
Dyer, D. G., Blackledge, J. A., Thorpe, S. R., & Baynes, J. W.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1991-06
Volume
266
Issue
18
Pages
11654-11660
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)99007-1
OpenAlex
W1532082751
Cited by
535
References
0
FWCI
11.43
Type
journal article
Language
en
Open access
hybrid

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