The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
Open accessAbstract
The promoter regions of many interferon-inducible genes share a short DNA sequence motif, termed the interferon consensus sequence (ICS) to which several regulatory proteins bind. A murine cDNA which encodes an ICS binding protein has been reported (M-ICSBP). The cloning of the human homologue of ICSBP (H-ICSBP) is described. H-ICSBP shares high sequence homology with its murine cognate. The derived sequence of H-ICSBP reveals restricted homology within the first 120 amino acids to three other interferon regulatory factors, IRF-1, IRF-2, and ISGF3 gamma. Truncated ICSBP lacking the first 33 amino-terminal amino acids fails to bind to the ICS, indicating that at least part of the DNA binding domain is located within the well conserved amino terminus. H-ICSBP is expressed exclusively in cell lines of hematopoietic origin. The results of transient transfection assays carried out either in hematopoietic or nonhematopoietic cells suggest that ICSBP acts as a negative regulatory factor on ICS-containing promoters. Furthermore, either interferon-gamma (IFN-gamma) or IFN-beta can alleviate the repression mediated by ICSBP. Therefore, ICSBP may be involved in maintaining submaximal transcriptional activity of IFN-inducible genes in hematopoietic cells. IFN treatment would then alleviate repression allowing maximal transcriptional activity of these genes.
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In the citing paper
“Likewise, previous reporter analysis indicated that ICSBP is a repressor of ISRE-dependent transcription (36, 57).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [57]
In the citing paper
“transfection of ICSBP alone reduced ISRE reporter activity by ∼ 40% irrespective of IFN𝛄 treatment, consistent with the previous finding that ICSBP represses ISRE-dependent transcription (36, 57).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [57]
In the citing paper
“Interferon (IFN) consensus sequence binding protein (ICSBP)/IFN regulatory factor (IRF)-8 is an IFN g -inducible transcription factor of the IRF family and regulates transcription through multiple target DNA elements, such as IFN-stimulated response element (ISRE), Ets/IRF composite element, and IFNg activation site (GAS).”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [6]
In the citing paper
“ICSBP is expressed in the hematopoietic cells, including cells of the monocyte/macrophage lineage, B lymphocytes, and activated T lymphocytes, and is inducible by IFNg in these cells, suggesting its role in immune cells. (6,9-13)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [6]
In the citing paper
“Subsequent studies have shown that ICSBP is a transcriptional repressor acting through the IFN-stimulated response element (ISRE). (6,20,21)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [6]
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Cited by
Sorted by citations
CELLULAR RESPONSES TO INTERFERON-γ
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IRF Family of Transcription Factors as Regulators of Host Defense
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Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor
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Metadata
- Authors
- Weisz, A., Marx, P., Sharf, R., Appella, E., Driggers, P. H., Ozato, K., & Levi, B. Z.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-12
- Volume
- 267
- Issue
- 35
- Pages
- 25589-25596
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1528284784
- Cited by
- 152
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- IRF8, interferon-stimulated genes, enhancer repression, negative transcriptional regulation, interferon regulatory factors, IRF1, IRF2, DNA-binding domain, hematopoietic cells, interferon-gamma, interferon-beta, transcriptional regulation
- MeSH terms
- Interferon Regulatory Factor-8, Amino Acid Sequence, Base Sequence, beta-Galactosidase, Carrier Proteins, Cell Line, Cycloheximide, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, HeLa Cells, Humans, Interferon-gamma, Lung, Molecular Sequence Data, Plasmids, Promoter Regions, Genetic, Recombinant Proteins, Repressor Proteins, RNA, Messenger, Transfection, Tumor Cells, Cultured, Blotting, Northern, Chloramphenicol O-Acetyltransferase, Gene Library, Gene Expression Regulation, Neoplastic, Interferon-beta, Sequence Homology, Amino Acid, Interferon Regulatory Factors
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