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Stabilization of Human Serum Albumin by the Binding of Phycocyanobilin, a Bioactive Chromophore of Blue-Green Alga Spirulina: Molecular Dynamics and Experimental Study

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Arthrospira maxima (Spirulina) and C-phycocyanin prevent the progression of chronic kidney disease and its cardiovascular complications

Memije-Lazaro, I. N., Blas-Valdivia, V., Franco-Colín, M., & Cano-Europa, E. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.01.013 · Cited by 46 · see citing works

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit, L., Vernès, L., & Cadoret, J. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02372-9 · Cited by 45 · see citing works

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

McCarty, M. F., & Lerner, A. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa139 · Cited by 44 · see citing works

Absorption and fluorescence spectra of open-chain tetrapyrrole pigments–bilirubins, biliverdins, phycobilins, and synthetic analogues

Taniguchi, M., & Lindsey, J. S. (2023) · Journal of Photochemistry and Photobiology C Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2023.100585 · Cited by 41 · see citing works

Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics

Uda, Y., Miura, H., Goto, Y., Yamamoto, K., Mii, Y., Kondo, Y., Takada, S., & Aoki, K. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.0c00477 · Cited by 41 · see citing works

Algae as a Source of Phycocyanin and Other Industrially Important Pigments

Dasgupta, C. N. (2015) · Springer eBooks · doi:10.1007/978-3-319-22813-6_12 · Cited by 40 · see citing works

Purification and Characterization of Recombinant Affinity Peptide‐Tagged Oat Phytochrome A

Murphy, J. T., & Lagarias, J. C. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb01920.x · Cited by 40 · see citing works

Biosynthesis of Phycobiliproteins in Cyanobacteria

Schluchter, W. M., & Glazer, A. N. (1999) · Springer eBooks · doi:10.1007/978-1-4615-4827-0_10 · Cited by 39 · see citing works

Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure

McCarty, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073321 · Cited by 40 · see citing works

Photochromic Biliproteins from the Cyanobacterium Anabaena sp. PCC 7120: Lyase Activities, Chromophore Exchange, and Photochromism in Phytochrome AphA

Zhao, K., Ran, Y., Li, M., Sun, Y.-N., Zhou, M., Storf, M., Kupka, M., Böhm, S., Bubenzer, C., & Scheer, H. (2004) · Biochemistry · doi:10.1021/bi0491548 · Cited by 35 · see citing works

Excited-State Processes in Phycocyanobilin Studied by Femtosecond Spectroscopy

Bischoff, M., Hermann, G., Rentsch, S. K., Strehlow, D., Winter, S., & Chosrowjan, H. (2000) · The Journal of Physical Chemistry B · doi:10.1021/jp992083f · Cited by 34 · see citing works

Biliverdin Amides Reveal Roles for Propionate Side Chains in Bilin Reductase Recognition and in Holophytochrome Assembly and Photoconversion

Shang, L., Rockwell, N. C., Martin, S. S., & Lagarias, J. C. (2010) · Biochemistry · doi:10.1021/bi100756x · Cited by 33 · see citing works

A randomized, double‐blind placebo‐controlled add‐on trial to assess the efficacy, safety, and anti‐atherogenic effect of spirulina platensis in patients with inadequately controlled type 2 diabetes mellitus

Karizi, S. R., Armanmehr, F., Azadi, H. G., Zahroodi, H. S., Ghalibaf, A. M., Bazzaz, B. S. F., Abbaspour, M., Boskabadi, S. J., Eslami, S., & Taherzadeh, Z. (2023) · Phytotherapy Research · doi:10.1002/ptr.7674 · Cited by 32 · see citing works

Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention

McCarty, M. F. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.09.039 · Cited by 30 · see citing works

Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells

McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.07.045 · Cited by 30 · see citing works

NMR Verification of Helical Conformations of Phycocyanobilin in Organic Solvents

Knipp, B., Müller, M., Metzler‐Nolte, N., Balaban, T. S., Braslavsky, S. E., & Schaffner, K. (1998) · Helvetica Chimica Acta · doi:10.1002/hlca.19980810509 · Cited by 30 · see citing works

Near-infrared imaging in fission yeast using a genetically encoded phycocyanobilin biosynthesis system

Sakai, K., Kondo, Y., Fujioka, H., Kamiya, M., Aoki, K., & Goto, Y. (2021) · Journal of Cell Science · doi:10.1242/jcs.259315 · Cited by 28 · see citing works

HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF SPIRULINA PLATENSIS, PHYCOCYANIN, PHYCOCYANOPEPTIDE AND PHYCOCYANOBILIN ON MALE DIABETIC RATS

El-Sayed, E.-S., Hikal, M., Abo El- Khair, B., El-Ghobashy, R., & El-Assar, A. (2018) · Arab Universities Journal of Agricultural Sciences · doi:10.21608/ajs.2018.28365 · Cited by 26 · see citing works

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

McCarty, M. F., DiNicolantonio, J. J., & Lerner, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042140 · Cited by 26 · see citing works

Beneficial effects of phycobiliproteins from Spirulina maxima in a preeclampsia model

Castro-García, S. Z., Chamorro, G., Quevedo-Corona, L., McCarty, M. F., & Bobadilla-Lugo, R. A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.011 · Cited by 24 · see citing works

NADPH Oxidase Activity in Cerebral Arterioles Is a Key Mediator of Cerebral Small Vessel Disease-Implications for Prevention

McCarty, M. (2015) · Healthcare · doi:10.3390/healthcare3020233 · Cited by 23 · see citing works

Phytochromes and Cyanobacteriochromes: Photoreceptor Molecules Incorporating a Linear Tetrapyrrole Chromophore

Fushimi, K., & Narikawa, R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-8763-4_10 · Cited by 22 · see citing works

Misregulation of tetrapyrrole biosynthesis in transgenic tobacco seedlings expressing mammalian biliverdin reductase

Franklin, K. A., Linley, P. J., Montgomery, B. L., Lagarias, J. C., Thomas, B., Jackson, S. D., & Terry, M. J. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01840.x · Cited by 20 · see citing works

Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice

Liu, J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i18.5465 · Cited by 20 · see citing works

Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation

Basdeo, S. A., Campbell, N. K., Sullivan, L. M., Flood, B., Creagh, E. M., Mantle, T. J., Fletcher, J. M., & Dunne, A. (2016) · Translational research · doi:10.1016/j.trsl.2016.07.011 · Cited by 20 · see citing works

Mesobiliverdin IXα Enhances Rat Pancreatic Islet Yield and Function

Ito, T., Chen, D., Chang, C. T., Kenmochi, T., Saito, T., Suzuki, S., & Takemoto, J. Y. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00050 · Cited by 19 · see citing works

Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

McCarty, M. F., DiNicolantonio, J. J., & Lerner, A. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s307549 · Cited by 18 · see citing works

A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity

Takao, H., Hirabayashi, K., Nishigaya, Y., Kouriki, H., Nakaniwa, T., HAGIWARA, Y., Harada, J., Sato, H., Yamazaki, T., Sakakibara, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14397 · Cited by 16 · see citing works

Potential complementarity of high-flavanol cocoa powder and spirulina for health protection

McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.09.060 · Cited by 16 · see citing works

Chromophore composition of the phycobiliprotein Cr-PC577 from the cryptophyte Hemiselmis pacifica

Overkamp, K. E., Schäkermann, S., Aras, M., Helling, S., Marcus, K., Bandow, J. E., Hoef‐Emden, K., & Frankenberg‐Dinkel, N. (2014) · Photosynthesis Research · doi:10.1007/s11120-014-0029-1 · Cited by 16 · see citing works

Clinical potential of phycocyanobilin for induction of T regulatory cells in the management of inflammatory disorders

McCarty, M. F. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.08.041 · Cited by 15 · see citing works

Nutraceutical Aid for Allergies – Strategies for Down-Regulating Mast Cell Degranulation

McCarty, M. F., Lerner, A., DiNicolantonio, J. J., & Benzvi, C. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s332307 · Cited by 14 · see citing works

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review

Sokary, S., Bawadi, H. A., Zakaria, Z. Z., & Al‐Asmakh, M. (2024) · Journal of Dietary Supplements · doi:10.1080/19390211.2023.2301366 · Cited by 12 · see citing works

Optical Control of Cell Signaling with Red/Far-Red Light-Responsive Optogenetic Tools in Caenorhabditis elegans

Oda, S., Sato-Ebine, E., Nakamura, A., Kimura, K. D., & Aoki, K. (2023) · ACS Synthetic Biology · doi:10.1021/acssynbio.2c00461 · Cited by 11 · see citing works

Identification of two recessive etiolation genes (py1, py2) in pakchoi (Brassica rapa L. ssp. chinensis)

Zhang, K., Yu, M., Li, W., Shan, X., Wang, N., & Feng, H. (2020) · BMC Plant Biology · doi:10.1186/s12870-020-2271-3 · Cited by 11 · see citing works

A nutraceutical strategy for downregulating TGFβ signalling: prospects for prevention of fibrotic disorders, including post-COVID-19 pulmonary fibrosis

DiNicolantonio, J., McCarty, M., Barroso-Aranda, J., Assanga, S., Luján, L. M. L., O, & Keefe, J. H. (2021) · Open Heart · doi:10.1136/openhrt-2021-001663 · Cited by 11 · see citing works

Extraction, Purification, Bioactivity and Pharmacological Effects of Phycobiliproteins (PBPs): A Review

Madji, S., Antih, J., Tabib, M., Silvestre, C., Ghennai, A., Warnery, A., Vaillant, F. E., Bichon, F., Echalier, A., & Poucheret, P. (2025) · Analytica—A Journal of Analytical Chemistry and Chemical Analysis · doi:10.3390/analytica6040044 · Cited by 12 · see citing works

Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21

McCarty, M. F. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0057 · Cited by 10 · see citing works

Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases

Jayanti, S. D., Vı́tek, L., Verde, C. D., Llido, J. P., Sukowati, C. H. C., Tiribelli, C., & Gazzin, S. (2024) · Biomolecules · doi:10.3390/biom14010063 · Cited by 9 · see citing works

Assessment of the Anticancer Potentials of the Free and Metal-Organic Framework (UiO-66) – Delivered Phycocyanobilin

Rashed, S. A., Hammad, S., Eldakak, M., Khalil, I. A. H., & Osman, A. I. (2022) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2022.08.038 · Cited by 9 · see citing works

Challenges associated withRhynchophorus phoenicis Fabricius (Coleoptera: Curculionidae) farming: a case study of the Ejisu-Juaben Municipality

Debrah, S. K., Anankware, J. P., Asomah, S., & Ofori, D. O. (2022) · Journal of Insects as Food and Feed · doi:10.3920/jiff2021.0219 · Cited by 8 · see citing works

NAPDH oxidase mediates glucolipotoxicity-induced beta cell dysfunction – Clinical implications

McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.09.062 · Cited by 8 · see citing works

Effect of a weight loss diet with or without Spirulina supplementation on serum lipids and antioxidant capacity of overweight dogs

Stefanutti, D., Serva, L., Berlanda, M., Bonsembiante, F., Gabai, G., Franceschinis, E., Cavazzoni, M., Morelli, G., & Ricci, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-80843-y · Cited by 5 · see citing works

Expression, Purification, and Spectral Characterization of Phytochromes

Han, Y., Cho, J., & Kim, J. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9612-4_7 · Cited by 5 · see citing works

Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases

McCarty, M. F., & DiNicolantonio, J. J. (2016) · Healthcare · doi:10.3390/healthcare4030060 · Cited by 5 · see citing works

Tetrapyrrole Compounds of Cyanobacteria

Watanabe, F., Yabuta, Y., & Bito, T. (2014) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63281-4.00011-2 · Cited by 4 · see citing works

Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity—Nutraceutical Options

McCarty, M. F., & DiNicolantonio, J. J. (2021) · Healthcare · doi:10.3390/healthcare10010003 · Cited by 3 · see citing works

Biliverdin Amides Reveal Roles for Propionate Side Chains in Bilin Reductase Recognition and in Holophytochrome Assembly and Photoconversion

Shang, L., Rockwell, N. C., Martin, S. S., & Lagarias, J. C. (2010) · Biochemistry · doi:10.1021/bi100756x · Cited by 33 · see citing works

Functional Genomic Analysis of the HY2 Family of Ferredoxin-Dependent Bilin Reductases from Oxygenic Photosynthetic Organisms

Frankenberg‐Dinkel, N., Mukougawa, K., Kohchi, T., & Lagarias, J. C. (2001) · The Plant Cell · doi:10.1105/tpc.13.4.965 · Cited by 238 · see citing works

Functional Genomic Analysis of the HY2 Family of Ferredoxin-Dependent

From, B. R., Organisms, O. P., Frankenberg, N., Mukougawa, A. K., Kohchi, B. T., & A, J. C. L. (2013)

Biliverdin Reductase-Induced Phytochrome Chromophore Deficiency in Transgenic Tobacco

Montgomery, B. L., Franklin, K. A., Terry, M. J., Thomas, B., Jackson, S. D., Crepeau, M., & Lagarias, J. C. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.1.266 · Cited by 20 · see citing works

On the evolution of the plant phytochrome chromophore biosynthesis

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