Cited by 108Lipid metabolism and disordersDiabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular Health

Postprandial lipemia as a cardiometabolic risk factor

Pirillo, Angela, Norata, Giuseppe Danilo, Catapano, Alberico Luigi·2014·Current Medical Research and Opinion

Abstract

High levels of fasting circulating triglycerides (TG) represent an independent risk factor for cardiovascular disease. In western countries, however, people spend most time in postprandial conditions, with continuous fluctuation of lipemia due to increased levels of TG-rich lipoproteins (TRLs), including chylomicrons (CM), very low density lipoproteins (VLDL), and their remnants. Several factors contribute to postprandial lipid metabolism, including dietary, physiological, pathological and genetic factors. The presence of coronary heart disease, type 2 diabetes, insulin resistance and obesity is associated with higher postprandial TG levels compared with healthy conditions; this association is present also in subjects with normal fasting TG levels. Increasing evidence indicates that impaired metabolism of postprandial lipoproteins contributes to the pathogenesis of coronary artery disease, suggesting that lifestyle modifications as well as pharmacological approaches aimed at reducing postprandial TG levels might help to decrease the cardiovascular risk.

Integrity signals

Registry

Crossref · 10.1185/03007995.2014.909394

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172 of 172 references verified0 citation errors · 0 not checkable

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Authors
Pirillo, A., Norata, G. D., & Catapano, A. L.
Affiliations
  • MultiMedica (IT)
  • Queen Mary University of London (GB)
  • University of Milan (IT)
Corresponding author
Pirillo, Angela
Venue
Current Medical Research and Opinion
Published
2014-05-02
Volume
30
Issue
8
Pages
1489-1503
ISSN
  • 0300-7995 (ISSN-L)
  • 1473-4877
OpenAlex
W2012632253
Cited by
108
References
172
Citations by year
2026: 2 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 14 · 2020: 8 · 2019: 15 · 2018: 7 · 2017: 9 · 2016: 17 · 2015: 10 · 2014: 2
FWCI
2.02
Type
journal article
Language
en
Open access
closed
Locations
  • Current Medical Research and Opinion (publishedVersion)
  • PubMed (publishedVersion)
  • eSpace (Curtin University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
postprandial lipemia, triglycerides, triglyceride-rich lipoproteins, chylomicrons, VLDL, cardiovascular risk, coronary artery disease, type 2 diabetes, insulin resistance, obesity, postprandial lipid metabolism, cardiometabolic risk
MeSH terms
Hypolipidemic Agents, Cardiovascular Diseases, Humans, Hyperlipoproteinemias, Life Style, Risk Factors, Hypertriglyceridemia, Postprandial Period, Lipid Metabolism

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