The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
Open accessAbstract
Children's Hospital Medical Center/Harvard Medical School, Boston, MA 021 15,' Institut fur Humangenetik und Genetische Poliklinik der Philipps-Universitat Marburg, Bahnhofstrasse 7A, West Germany,' Gladstone Foundation Laboratories, San Francisco, CA 94 140; Cardiovascular Research Institute, University of California, San Francisco, CA 941 43; Health Science Center, University of Texas, Dallas, T X 74235,5 Lipid Research Center, Washington University School of Medicine, St. Louis, M O 63110; Harborview Medical Center, Seattle, WA 98104; and Columbia College of Physicians and Surgeons, New York, NY 10032*
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In the citing paper
“The two genotypes combine into six common APOE genotypes, ε22, ε32, ε42, ε33, ε43 and ε44, corresponding to six plasma apoE phenotypes: apoE22, apoE32, apoE42, apoE33, apoE43 and apoE44 [14].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [14]
In the citing paper
“There are three common APOE alleles in the general population defined as: APOE ɛ2, APOE ɛ3, and APOE ɛ4 [2].”
From Discovery of a Missense Mutation (Q222K) of the APOE Gene from the Australian Imaging, Biomarker and Lifestyle Study (2023) · cites this paper as [2]
In the citing paper
“Apolipoprotein E (apoE) is one of the key apolipoproteins in blood lipid transport.”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
Citations
Cites
Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777
Self-citationPolymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
UTERMANN, G., HEES, M., & STEINMETZ, A. (1977) · Nature · doi:10.1038/269604a0 · Cited by 666
Self-citationZannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
Self-citationWindler, E. E. T., Kovanen, P. T., Chao, Y. S., Brown, M. S., Havel, R. J., & Goldstein, J. L. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70487-6 · Cited by 456
Self-citationInnerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433
Self-citationSherrill, B. C., Innerarity, T. L., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85951-3 · Cited by 426
Self-citationDeterminants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.
Windler, E. E. T., Chao, Y. S., & Havel, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70811-4 · Cited by 365
Self-citationWindler, E., Chao, Y., & Havel, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70647-4 · Cited by 365
Self-citationEffect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.
Shelburne, F. A., Hanks, J., Meyers, W., & Quarfordt, S. H. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109710 · Cited by 358
(1981) · PubMed · Cited by 341
Self-citation
Research works printed but not linked: 2
- Utermann, G., A. Steinmetz, and W. Weber. 1982. Polymorphism of human apolipoprotein E: genetic control and gene frequencies. Am. J. Hum. Genet. In press.
- Sherrill, 1980, Addition of E-apoprotein to cholesterol-rich fluorescent lipid dispersion increases liver recognition and uptake, Circulation., 62, 44
Cited by
Sorted by citations
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Self-citationPlump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Self-citationApolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836
Self-citationGenetic associations with human longevity at the APOE and ACE loci
Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D. (1994) · Nature Genetics · doi:10.1038/ng0194-29 · Cited by 1,095
Plasma lipoproteins: apolipoprotein structure and function.
Mahley, R. W., Innerarity, T. L., Rall, S. C., & Weisgraber, K. H. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34443-6 · Cited by 1,155
Self-citation
Metadata
- Authors
- Zannis, V. I., Breslow, J. L., Utermann, G., Mahley, R. W., Weisgraber, K. H., Havel, R. J., Goldstein, J. L., Brown, M. S., Schonfeld, G., Hazzard, W. R., & Blum, C.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1982-08
- Volume
- 23
- Issue
- 6
- Pages
- 911-914
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1770880387
- Cited by
- 436
- References
- 31
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 5 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 12 · 2014: 15 · 2013: 11 · 2012: 11
- FWCI
- 25.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, APOE genotype, nomenclature, genetic variants, lipoprotein metabolism
- MeSH terms
- Apolipoproteins, Apolipoproteins E, Genotype, Humans, Terminology as Topic, Phenotype
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