The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
Open accessAbstract
Children's Hospital Medical Center/Harvard Medical School, Boston, MA 021 15,' Institut fur Humangenetik und Genetische Poliklinik der Philipps-Universitat Marburg, Bahnhofstrasse 7A, West Germany,' Gladstone Foundation Laboratories, San Francisco, CA 94 140; Cardiovascular Research Institute, University of California, San Francisco, CA 941 43; Health Science Center, University of Texas, Dallas, T X 74235,5 Lipid Research Center, Washington University School of Medicine, St. Louis, M O 63110; Harborview Medical Center, Seattle, WA 98104; and Columbia College of Physicians and Surgeons, New York, NY 10032*
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The two genotypes combine into six common APOE genotypes, ε22, ε32, ε42, ε33, ε43 and ε44, corresponding to six plasma apoE phenotypes: apoE22, apoE32, apoE42, apoE33, apoE43 and apoE44 [14].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [14]
In the citing paper
“There are three common APOE alleles in the general population defined as: APOE ɛ2, APOE ɛ3, and APOE ɛ4 [2].”
From Discovery of a Missense Mutation (Q222K) of the APOE Gene from the Australian Imaging, Biomarker and Lifestyle Study (2023) · cites this paper as [2]
In the citing paper
“Apolipoprotein E (apoE) is one of the key apolipoproteins in blood lipid transport.”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
In the citing paper
“It has the following features: high hydrophobicity, the ability to bind to the low-density-lipoprotein (LDL) receptor and related receptors, production in various tissues throughout the body, acting as a central apoprotein of cerebrospinal fluid lipoproteins, having three major isoforms (apoE2, apoE3, and apoE4) that vary in their function and susceptibility to genetic mutations1).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [1]
Citations
Cites
Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777
Self-citationPolymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
UTERMANN, G., HEES, M., & STEINMETZ, A. (1977) · Nature · doi:10.1038/269604a0 · Cited by 666
Self-citationZannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
Self-citationWindler, E. E. T., Kovanen, P. T., Chao, Y. S., Brown, M. S., Havel, R. J., & Goldstein, J. L. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70487-6 · Cited by 456
Self-citationInnerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433
Self-citationSherrill, B. C., Innerarity, T. L., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85951-3 · Cited by 426
Self-citationDeterminants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.
Windler, E. E. T., Chao, Y. S., & Havel, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70811-4 · Cited by 365
Self-citationWindler, E., Chao, Y., & Havel, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70647-4 · Cited by 365
Self-citationEffect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.
Shelburne, F. A., Hanks, J., Meyers, W., & Quarfordt, S. H. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109710 · Cited by 358
(1981) · PubMed · Cited by 341
Self-citation
Research works printed but not linked: 2
- Utermann, G., A. Steinmetz, and W. Weber. 1982. Polymorphism of human apolipoprotein E: genetic control and gene frequencies. Am. J. Hum. Genet. In press.
- Sherrill, 1980, Addition of E-apoprotein to cholesterol-rich fluorescent lipid dispersion increases liver recognition and uptake, Circulation., 62, 44
Cited by
Sorted by citations
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Self-citationPlump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Self-citationApolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836
Self-citationGenetic associations with human longevity at the APOE and ACE loci
Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D. (1994) · Nature Genetics · doi:10.1038/ng0194-29 · Cited by 1,095
Plasma lipoproteins: apolipoprotein structure and function.
Mahley, R. W., Innerarity, T. L., Rall, S. C., & Weisgraber, K. H. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34443-6 · Cited by 1,155
Self-citationApolipoprotein E in Alzheimer’s disease and other neurological disorders
Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857
Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders
Mahley, R. W. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1427-y · Cited by 837
Self-citationApolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Self-citationPitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47945-8 · Cited by 714
Self-citation(1985) · PubMed · Cited by 706
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693
Self-citationCharidimou, A., Gang, Q., & Werring, D. J. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301308 · Cited by 611
Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease
Barage, S. H., & Sonawane, K. D. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.06.008 · Cited by 579
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800069-jlr200 · Cited by 580
Self-citationA Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward
Belloy, M. E., Napolioni, V., & Greicius, M. D. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.056 · Cited by 570
Expression of apolipoprotein E during nerve degeneration and regeneration.
Ignatius, M. J., Gebicke‐Haerter, P. J., Skene, J. H. P., Schilling, J., Weisgraber, K. H., Mahley, R. W., & Shooter, E. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1125 · Cited by 571
Self-citationHallman, D. M., Boerwinkle, E., Saha, N., Sandholzer, C., Menzel, H., Csazar, A., & Utermann, G. (1991) · PubMed · Cited by 511
Self-citationHepatic uptake of chylomicron remnants
Cooper, A. D. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34932-4 · Cited by 499
Mahley, R. W., Huang, Y., & Rall, S. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32417-2 · Cited by 447
Self-citationDietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.
Weintraub, M. S., Eisenberg, S., & Breslow, J. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113243 · Cited by 418
Self-citationMartins, I. J., Hone, E., Foster, J. K., Sünram-Lea, S. I., Gnjec, A., Fuller, S. J., Nolan, D., Gandy, S. E., & Martins, R. N. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001854 · Cited by 388
Hua, X., Leow, A., Parikshak, N., Lee, S., Chiang, M.-C., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.013 · Cited by 372
Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.
Das, H. K., McPherson, J. D., Bruns, G. A. P., Karathanasis, S. K., & Breslow, J. L. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88963-3 · Cited by 354
Self-citationApolipoprotein E: an important gene and protein to follow in laboratory medicine
Siest, G., Pillot, T., Régis-Bailly, A., Leininger-Muller, B., Steinmetz, J., Galteau, M. M., & Visvikis, S. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.8.1068 · Cited by 347
Gerdes, L. U., Klausen, I. C., Sihm, I., Færgeman, O., & Vogler, G. P. (1992) · Genetic Epidemiology · doi:10.1002/gepi.1370090302 · Cited by 316
Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid β Peptide
Hashimoto, T., Serrano-Pozo, A., Hori, Y., Adams, K. W., Takeda, S., Banerji, A. O., Mitani, A., Joyner, D., Thyssen, D. H., Bacskai, B. J., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1542-12.2012 · Cited by 294
Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.
Weisgraber, K. H., Rall, S. C., Mahley, R. W., Milne, R. W., Marcel, Y. L., & Sparrow, J. T. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35898-2 · Cited by 240
Self-citationOrdovas, J. M., Litwack-Klein, L., Wilson, P. W., Schaefer, M. M., & Schaefer, E. J. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38690-9 · Cited by 238
Apolipoprotein E synthesis in human kidney, adrenal gland, and liver
Blue, M. L., Williams, D. L., Zucker, S., Khan, S. A., & Blum, C. B. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.1.283 · Cited by 226
Self-citationLaws, S. M., Hone, E., Gandy, S., & Martins, R. N. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01615.x · Cited by 223
Luc, G., Bard, J., Arveiler, D., Evans, A., Cambou, J., Bingham, A., Amouyel, P., Schaffer, P., Ruidavets, J., & Cambien, F. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.9.1412 · Cited by 215
Lalazar, A., Weisgraber, K. H., Rall, S. C., Giladi, H., Innerarity, T. L., Levanon, A. Z., Boyles, J. K., Amit, B., Gorecki, M., & Mahley, R. W. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68957-4 · Cited by 209
Self-citationGenetics of Alzheimer’s Disease
Chouraki, V. A., & Seshadri, S. S. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800149-3.00005-6 · Cited by 220
Sethi, S. M., Gamez, J. D., Vrana, J. A., Theis, J. D., Bergen, H. R., Zipfel, P. F., Doǧan, A., & Smith, R. J. (2009) · Kidney International · doi:10.1038/ki.2008.657 · Cited by 198
Oxidative Insults Are Associated with Apolipoprotein E Genotype in Alzheimer's Disease Brain
Ramassamy, C., Averill‐Bates, D. A., Beffert, U., Théroux, L., Lussier‐Cacan, S., Cohn, J. S., Christen, Y., Schoofs, A. R., Davignon, J., & Poirier, J. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0273 · Cited by 194
Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition
Rodriguez, G. A., Tai, L. M., LaDu, M. J., & Rebeck, G. W. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-111 · Cited by 193
Reduced Hippocampal Volume in Healthy Young ApoE4 Carriers: An MRI Study
O’Dwyer, L., Lamberton, F., Matura, S., Tanner, C. J., Scheibe, M., Miller, J., Rujescu, D., Prvulovic, D., & Hampel, H. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048895 · Cited by 199
Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.
Zannis, V. I., McPherson, J. D., Goldberger, G., Karathanasis, S. K., & Breslow, J. L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91039-2 · Cited by 189
Self-citationApoE Lipidation as a therapeutic target in Alzheimer’s disease
Lanfranco, M. F., Ng, C. A., & Rebeck, G. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176336 · Cited by 189
Prince, J. A., Feuk, L., Howell, W. M., Jobs, M., Emahazion, T., Blennow, K., & Brookes, A. J. (2001) · Genome Research · doi:10.1101/gr.150201 · Cited by 188
Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell line
Traber, M. G., Kayden, H. J., & Rindler, M. J. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38598-9 · Cited by 183
Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2
Breslow, J. L., Zannis, V. I., SanGiacomo, T. R., Third, J. L., Tracy, T., & Glueck, C. J. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38060-3 · Cited by 174
Self-citationRole of apolipoprotein E in neurodegenerative diseases
Giau, V. V., Bagyinszky, E., An, S. S. A., & Kim, S. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s84266 · Cited by 177
Buckley, M. M.-T., Goa, K. L., Price, A. H., & Brogden, R. N. (1989) · Drugs · doi:10.2165/00003495-198937060-00002 · Cited by 163
Apolipoprotein E and Alzheimer's disease
Troutwine, B., Hamid, L., Lysaker, C. R., Strope, T. A., & Wilkins, H. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.10.002 · Cited by 179
The role of apolipoprotein E genetic variants in lipoprotein disorders.
RALL, S. C., & MAHLEY, R. W. (1992) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1992.tb01254.x · Cited by 150
Self-citation[13] Isolation and characterization of apolipoprotein E
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28073-8 · Cited by 150
Self-citationApolipoprotein E and the Apolipoprotein E-Deficient Mouse
Plump, A. S., & Breslow, J. L. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.002431 · Cited by 154
Self-citationDemant, T., Bedford, D., Packard, C. J., & Shepherd, J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115459 · Cited by 145
Nathan, B. P., Jiang, Y., Wong, G. K., Shen, F., Brewer, G. J., & Struble, R. G. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03367-4 · Cited by 169
Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels
de Knijff, P., van den Maagdenberg, A. M. J. M., Frants, R. R., & Havekes, L. M. (1994) · Human Mutation · doi:10.1002/humu.1380040303 · Cited by 137
Rodriguez, G. A., Burns, M. P., Weeber, E. J., & Rebeck, G. W. (2013) · Learning & Memory · doi:10.1101/lm.030031.112 · Cited by 147
The Genetics of the Human APOE Polymorphism
Seripa, D., D’Onofrio, G., Panza, F., Cascavilla, L., Masullo, C., & Pilotto, A. (2011) · Rejuvenation Research · doi:10.1089/rej.2011.1169 · Cited by 128
Rasmussen, K. L. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.10.037 · Cited by 125
Kinetics of chylomicron remnant clearance in normal and in hyperlipoproteinemic subjects.
Cortner, J. A., Coates, P. M., Le, N., Cryer, D. R., Ragni, M. C., Faulkner, A., & Langer, T. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38721-6 · Cited by 123
Self-association of human apolipoprotein E3 and E4 in the presence and absence of phospholipid
Perugini, M. A., Schuck, P., & Howlett, G. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005565200 · Cited by 118
Kameda, K., MATSUZAWA, Y., KUBO, M., Ishikawa, K., Maejima, I., Yamamura, T., Yamamoto, A. C., & Tarui, S. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90171-0 · Cited by 113
Eto, M., Watanabe, K., & Ishii, K. (1986) · Clinical Genetics · doi:10.1111/j.1399-0004.1986.tb00547.x · Cited by 112
Weisgraber, K. H., Rall, S. C., Innerarity, T. L., Mahley, R. W., Kuusi, T., & Ehnholm, C. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111287 · Cited by 111
Self-citationAlaupovic, P. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)63004-3 · Cited by 109
Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review
Kuhlmann, I., Minihane, A. M., Huebbe, P., Nebel, A., & Rimbach, G. H. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-8 · Cited by 107
DeSimone, C. V., Graff‐Radford, J., El‐Harasis, M. A., Rabinstein, A. A., Asirvatham, S. J., & Holmes, D. R. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.07.724 · Cited by 106
Apolipoprotein E Isoform Phenotype and LDL Subclass Response to a Reduced-Fat Diet
Dreon, D. M., Fernstrom, H. A., Miller, B., & Krauss, R. M. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.1.105 · Cited by 100
Hornick, C. A., Hamilton, R. L., Spaziani, E., Enders, G. H., & Havel, R. J. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.100.5.1558 · Cited by 102
Self-citationLipid metabolism in Alzheimer’s disease
Liu, Q., & Zhang, J. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1410-3 · Cited by 101
Identification and DNA sequence of a human apolipoprotein E cDNA clone.
Breslow, J. L., McPherson, J. D., NUSSBAUM, A. L., Williams, H. W., Lofquist-Kahl, F., Karathanasis, S. K., & Zannis, V. I. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33328-3 · Cited by 99
Self-citationNo ɛ4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects
Lemaître, H., Crivello, F., Dufouil, C., Grassiot, B., Tzourio, C., Alpérovitch, A., & Mazoyer, B. M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.016 · Cited by 102
Havekes, L., de Wit, E., Leuven, J. G., Klasen, E., Utermann, W., Weber, W., & Beisiegel, U. (1986) · Human Genetics · doi:10.1007/bf00291607 · Cited by 99
Alaupovic, P. (1991) · Progress in Lipid Research · doi:10.1016/0163-7827(91)90008-s · Cited by 94
Yamamura, T., Yamamoto, A., Sumiyoshi, T., Hiramori, K., Nishioeda, Y., & Nambu, S. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111532 · Cited by 91
Eto, M., Saito, M., Okada, M., Kume, Y., Kawasaki, F., Matsuda, M., Yoneda, M., Matsuki, M., Takigami, S., & Kaku, K. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.34502 · Cited by 90
Genetic basis of lipoprotein disorders.
Breslow, J. L. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114176 · Cited by 91
Self-citationGenetic variation in human apolipoprotein E
Wardell, M. R., Suckling, P. A., & Janus, E. D. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38055-x · Cited by 89
Lipoproteins in the Central Nervous System: From Biology to Pathobiology
Raulin, A.-C., Martens, Y. A., & Bu, G. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-104801 · Cited by 89
Hussain, M. M., Zannis, V. I., & Plaitakis, A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47124-x · Cited by 88
Self-citationAtypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3.
Havel, R. J., Kotite, L., Kane, J. P., Tun, P., & Bersot, T. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110978 · Cited by 88
Self-citationVogel, T., Weisgraber, K. H., Zeevi, M. I., Ben-Artzi, H., Levanon, A. Z., Rall, S. C., Innerarity, T. L., Hui, D. Y., Taylor, J. M., & Kanner, D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8696 · Cited by 88
Self-citationHashimoto, Y., Jiang, H., Niikura, T., Ito, Y., Hagiwara, A., Umezawa, K., Abe, Y., Murayama, Y., & Nishimoto, I. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08401.2000 · Cited by 86
Sentí, M., Nogués, X., Pedro-Botet, J., Rubiés-Prat, J., & Vidal-Barraquer, F. (1992) · Circulation · doi:10.1161/01.cir.85.1.30 · Cited by 85
Rall, S. C., Newhouse, Y. M., Clarke, H. R., Weisgraber, K. H., McCarthy, B. J., Mahley, R. W., & Bersot, T. P. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113988 · Cited by 103
Self-citationApolipoprotein E gene polymorphism and Alzheimer's disease in Chinese population: a meta-analysis
Liu, M., Bian, C., Zhang, J., & Wen, F. (2014) · Scientific Reports · doi:10.1038/srep04383 · Cited by 72
Lipoprotein metabolism in nonalcoholic fatty liver disease
Jiang, Z. G., Simon, K. A., & Zemin, Y. (2013) · Journal of Biomedical Research · doi:10.7555/jbr.27.20120077 · Cited by 89
Olfactory function in apoE knockout mice
Nathan, B. P., Yost, J., Litherland, M. T., Struble, R. G., & Switzer, P. V. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00219-5 · Cited by 82
Increased frequencies of apolipoprotein ε2 and ε4 alleles in patients with ischemic heart disease
Eto, M., Watanabe, K., & Makino, I. (1989) · Clinical Genetics · doi:10.1111/j.1399-0004.1989.tb03186.x · Cited by 83
Effects of apoprotein E polymorphism on serum lipoprotein concentration.
Robertson, F. W., & Cumming, A. (1985) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.5.3.283 · Cited by 81
Molecular Genetic Findings in Suicidal Behavior: What is Beyond the Serotonergic System?
Rujescu, D., Thalmeier, A., Möller, H., Bronisch, T., & Giegling, I. (2006) · Archives of Suicide Research · doi:10.1080/13811110600897317 · Cited by 79
Genetic Mutations Affecting Human Lipoproteins, Their Receptors, and Their Enzymes
Zannis, V. I., Kardassis, D., & Zanni, E. E. (1993) · Advances in Human Genetics 21 · doi:10.1007/978-1-4615-3010-7_3 · Cited by 78
Self-citationApolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice
Karagiannides, I., Abdou, R. Y., Tzortzopoulou, A., Voshol, P. J., & Kypreos, K. E. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06619.x · Cited by 80
Association of Apolipoprotein E Polymorphisms in Patients with Non-Alcoholic Steatohepatitis
Sazcı, A., Akpınar, G., Aygün, C., Ergül, E., Şentürk, Ö., & Hülagü, S. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0271-5 · Cited by 77
MAHLEY, R. W., INNERARITY, T. L., RALL, S. C., & WEISGRABER, K. H. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb11860.x · Cited by 75
Self-citationEconomou-Petersen, E., Aessopos, A., Kladi, A., Flevari, P., Karabatsos, F., Fragodimitri, C., Nicolaidis, P., Vrettou, H., Vassilopoulos, D., Karagiorga‐Lagana, M., et al. (1998) · Blood · doi:10.1182/blood.v92.9.3455 · Cited by 75
Lee, Y., Kockx, M., Raftery, M. J., Jessup, W., Griffith, R., & Kritharides, L. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900430-mcp200 · Cited by 74
Marais, A. D., Solomon, G. A. E., & Blom, D. J. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2013.870526 · Cited by 70
Paik, Y., Chang, D. J., Reardon, C. A., Walker, M., Taxman, E., & Taylor, J. M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37710-x · Cited by 71
A new isoform of apolipoprotein E — Apo E-5 — Associated with hyperlipidemia and atherosclerosis
Yamamura, T., Yamamoto, A., Hiramori, K., & Nambu, S. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90019-4 · Cited by 70
A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency
Mabuchi, H., Itoh, H., Takeda, M., Kajinami, K., Wakasugi, T., Koizumi, J., Takeda, R., & Asagami, C. (1989) · Metabolism · doi:10.1016/0026-0495(89)90249-7 · Cited by 70
Apolipoprotein E polymorphism and plasma cholesterol response to probucol
Nestruck, A. C., Bouthillier, D., Sing, C. F., & Davignon, J. (1987) · Metabolism · doi:10.1016/0026-0495(87)90110-7 · Cited by 67
Martínez‐Morillo, E., Nielsen, H. M., Batruch, I., Drabovich, A. P., Begcevic, I., Lopez, M. F., Minthon, L., Bu, G., Mattsson, N., Portelius, E., et al. (2014) · Journal of Proteome Research · doi:10.1021/pr401060x · Cited by 67
Eto, M., Horita, K., Morikawa, A., Nakata, H., Okada, M., Saito, M., Nomura, M., Abiko, A., Iwashima, Y., Ikoda, A., et al. (1995) · Clinical Genetics · doi:10.1111/j.1399-0004.1995.tb04111.x · Cited by 65
Genetic Mutations Affecting Human Lipoprotein Metabolism
Zannis, V. I., & Breslow, J. L. (1985) · Advances in Human Genetics 14 · doi:10.1007/978-1-4615-9400-0_3 · Cited by 65
Self-citation
Metadata
- Authors
- Zannis, V. I., Breslow, J. L., Utermann, G., Mahley, R. W., Weisgraber, K. H., Havel, R. J., Goldstein, J. L., Brown, M. S., Schonfeld, G., Hazzard, W. R., & Blum, C.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1982-08
- Volume
- 23
- Issue
- 6
- Pages
- 911-914
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1770880387
- Cited by
- 436
- References
- 31
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 5 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 12 · 2014: 15 · 2013: 11 · 2012: 11
- FWCI
- 25.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, APOE genotype, nomenclature, genetic variants, lipoprotein metabolism
- MeSH terms
- Apolipoproteins, Apolipoproteins E, Genotype, Humans, Terminology as Topic, Phenotype
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
