Cited by 853Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismHistorical Medical Research and Treatments

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The discovery and development of HMG-CoA reductase inhibitors.

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Endo, A·1992·Journal of Lipid Research

DOI 10.1016/s0022-2275(20)41379-3

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Abstract

During the 1950s and 1960s, many cholesterol-lowering agents were reported and introduced into clinical use, in-

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Authors: Endo, A.
Corresponding author: Endo, A
ORCID: Endo, A
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1992-11
Volume: 33
Issue: 11
Pages: 1569-1582
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)41379-3
OpenAlex: W2148463229
Cited by: 847
References: 114
Citations by year: 2026: 11 · 2025: 19 · 2024: 31 · 2023: 22 · 2022: 25 · 2021: 26 · 2020: 23 · 2019: 20 · 2018: 35 · 2017: 28 · 2016: 37 · 2015: 41 · 2014: 39 · 2013: 43 · 2012: 35
FWCI: 16.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10200 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
Keywords: statins, cholesterol-lowering drugs, drug discovery, drug development
MeSH terms: Animals, Anticholesteremic Agents, Humans, Hypercholesterolemia, Lovastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, History, 20th Century

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The discovery and development of HMG-CoA reductase inhibitors.

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