Cited by 853Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismHistorical Medical Research and Treatments

The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.

The discovery and development of HMG-CoA reductase inhibitors.

Open access

Endo, A·1992·Journal of Lipid Research

DOI 10.1016/s0022-2275(20)41379-3

Open this paper in CoChat — free account

Abstract

During the 1950s and 1960s, many cholesterol-lowering agents were reported and introduced into clinical use, in-

Integrity signals

Registry

Crossref · 10.1016/s0022-2275(20)41379-3

Cites

114 of 114 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
Brown, G., Albers, J. J., Fisher, L. D., Schaefer, S. M., Lin, J.-T., Kaplan, C., Zhao, X.-Q., Bisson, B. D., Fitzpatrick, V. F., & Dodge, H. T. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011083231901 · Cited by 2,159
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 1,906
All ras proteins are polyisoprenylated but only some are palmitoylated
Hancock, J. F., Magee, A. I., Childs, J. E., & Marshall, C. J. (1989) · Cell · doi:10.1016/0092-8674(89)90054-8 · Cited by 1,775
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alberts, A. W., Chen, J., Kuron, G. W., Hunt, V. M., Huff, J. W., Hoffman, C., Rothrock, J. W., López, M., Joshua, H., Harris, E., et al. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.3957 · Cited by 1,630
Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease.
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-5-786_2 · Cited by 1,426
ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.
Endo, A., KURODA, M., & Tsujita, Y. (1976) · The Journal of Antibiotics · doi:10.7164/antibiotics.29.1346 · Cited by 954
Self-citation
Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity
Endo, A., Kuroda, M., & Tanzawa, K. (1976) · FEBS Letters · doi:10.1016/0014-5793(76)80996-9 · Cited by 800
Self-citation
HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia
Oates, J. A., Wood, A. J. J., & Grundy, S. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807073190105 · Cited by 760
Influence of nicotinic acid on serum cholesterol in man
Altschul, R., Hoffer, A., & Stephen, J. D. (1955) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(55)90070-9 · Cited by 726

Show all 114 references

Research works printed but not linked: 5

1988, The Lipid Research Clinics Coronary Primary Prevention Trial Results. 1. Reduction in the incidence of coronary heart disease, JAMA., 251, 351
Taupitz, 1959, The effects of estrogens on the serum cholesterol of male rats, Symp. Deut. Ges. En-dokrinol., 430
Endo, 1978, Effects of ML-236B, a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase, on cholesterol metabolism, Adv. Exp. Med. Biol., 109, 376
Shigematsu, 1979, Treatment of hypercholesterolemia with an HMG-CoA reductase inhibitor (CS-500). I. Phase I study in normal subjects, Geriat. Med. (Japan)., 17, 1564
Alberts, 1988, Lovastatin and simvastatin, Cah. Nutr. Diet., 23, 231

Sorted by citations

Items 201–300 of 853

Lowering effects of four different statins on serum triglyceride level
Branchi, A., Fiorenza, A. M., Rovellini, A., Torri, A., Muzio, F., Macor, S., & Sommariva, D. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050663 · Cited by 46
Suppression of neointimal thickening by a newly developed HMG‐CoA reductase inhibitor, BAYw6228, and its inhibitory effect on vascular smooth muscle cell growth
Igarashi, M., Takeda, Y., Mori, S., Ishibashi, N., 小松, 栄., Takahashi, K., Fuse, T., Yamamura, M., Kubo, K., Sugiyama, Y., et al. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701018 · Cited by 46
Lipid metabolism in cancer: Exploring phospholipids as potential biomarkers
Delmas, D., Mialhe, A., Cotte, A. K., Connat, J., Bouyer, F., Hermetet, F., & Aires, V. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118095 · Cited by 49
Statin drugs markedly inhibit testosterone production by rat Leydig cells in vitro: Implications for men
Klinefelter, G. R., Laskey, J. W., & AMANN, R. P. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.12.010 · Cited by 45
Statins: Perspectives in cancer therapeutics
Corcos, L., & Jossic-Corcos, C. L. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.02.002 · Cited by 50
Ultrasound assisted ionic liquid dispersive liquid phase extraction of lovastatin and simvastatin: A new pretreatment procedure
Mao, T., Hao, B., He, J., Li, W., Li, S., & Yu, Z. (2009) · Journal of Separation Science · doi:10.1002/jssc.200900337 · Cited by 45
Bioactive Plant Molecules, Sources and Mechanism of Action in the Treatment of Cardiovascular Disease
Liwa, A. C., Barton, E. N., Cole, W. C., & Nwokocha, C. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802104-0.00015-9 · Cited by 49
In vitro Anti-Tumor Effects of Statins on Head and Neck Squamous Cell Carcinoma: A Systematic Review
Pavan, L. M. C., Rêgo, D. F., Elias, S. T., Canto, G. D. L., & Guerra, E. N. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130476 · Cited by 45
Discovery and Combinatorial Synthesis of Fungal Metabolites Beauveriolides, Novel Antiatherosclerotic Agents
Tomoda, H., & Doi, T. (2007) · Accounts of Chemical Research · doi:10.1021/ar700117b · Cited by 45
Immunomodulatory and Anti-Inflammatory Activities of Statins
Mira, E., & Mañes, S. (2009) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153009789044383 · Cited by 45
Familial Hypercholesterolemia: Present and Future Management
Sjouke, B., Kusters, D. M., Kastelein, J. J. P., & Hovingh, G. K. (2011) · Current Cardiology Reports · doi:10.1007/s11886-011-0219-9 · Cited by 45
Low simvastatin concentrations reduce oleic acid-induced steatosis in HepG2 cells: An in vitro model of non-alcoholic fatty liver disease
ALKHATATBEH, M. J., LINCZ, L. F., & THORNE, R. F. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3069 · Cited by 44
Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes
Godoy, J. C., Niesman, I. R., Busija, A. R., Kassan, A., Schilling, J. M., Schwarz, A. M., Alvarez, E. A., Dalton, N. D., Drummond, J. C., Roth, D. M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800876r · Cited by 46
Asymmetric Synthesis of the HMG-CoA Reductase Inhibitor Atorvastatin Calcium: An Organocatalytic Anhydride Desymmetrization and Cyanide-Free Side Chain Elongation Approach
Chen, X., Xiong, F., Chen, W., He, Q., & Chen, F. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo402829b · Cited by 44
Targeting Cholesterol Metabolism as Efficient Antiviral Strategy Against the Hepatitis E Virus
Glitscher, M., Martín, D. H., Woytinek, K., Schmidt, B., Tabari, D., Scholl, C., Stingl, J., Seelow, E., Choi, M., & Hildt, E. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.002 · Cited by 43
3-hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic characterization of the gene product
Bochar, D. A., Brown, J. R., Doolittle, W. F., Klenk, H., Lam, W., Schenk, M. E., Stauffacher, C. V., & Rodwell, V. W. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.11.3632-3638.1997 · Cited by 43
Preclinical and clinical pharmacology of cerivastatin
Bischoff, H., & Heller, A. H. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00433-0 · Cited by 43
Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia
O’Hare, E. A., Wang, X., Montasser, M. E., Chang, Y.-P. C., Mitchell, B. D., & Zaghloul, N. A. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m046540 · Cited by 41
Simvastatin and atorvastatin attenuate VCAM-1 and uPAR expression on human endothelial cells and platelet surface expression of CD40 ligand
Stach, K., Nguyen, X. D., Lang, S., Elmas, E., Weiß, C., Borggrefe, M. M., Fischer, J., & Kälsch, T. (2012) · Cardiology Journal · doi:10.5603/cj.2012.0005 · Cited by 42
Measuring Mortality Reductions in Cancer Screening Trials
Hanley, J. A. (2011) · Epidemiologic Reviews · doi:10.1093/epirev/mxq021 · Cited by 42
Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma
Wang, C., Li, T., Yan, F., Cai, W., Zheng, J., Jiang, X., & Sun, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.157 · Cited by 42
Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol fed rats
Bok, S., Shin, Y. W., Bae, K., Jeong, T., Kwon, Y.-K., Park, Y. B., & Choi, M. (2000) · Nutrition Research · doi:10.1016/s0271-5317(00)00191-3 · Cited by 42
His865 is the catalytically important histidyl residue of Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Darnay, B. G., & Rodwell, V. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52894-5 · Cited by 42
PREVENTION OF PRIMARY NONFUNCTION OF CANINE ISLET AUTOGRAFTS BY TREATMENT WITH PRAVASTATIN1
Arita, S., Nagai, T., Ochiai, M., Sakamoto, Y., Shevlin, L., Smith, C. V., & Mullen, Y. (2002) · Transplantation · doi:10.1097/00007890-200201150-00003 · Cited by 41
Low-Density Lipoprotein Cholesterol-Lowering Drugs: A Narrative Review
Ferri, N., Ruscica, M., Fazio, S., & Corsini, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13040943 · Cited by 44
The Effect of Statins on Mortality in Septic Patients: A Meta-Analysis of Randomized Controlled Trials
Pasin, L., Landoni, G., Castro, M. L., Cabrini, L., Belletti, A., Feltracco, P., Finco, G., Carozzo, A., Chiesa, R., & Zangrillo, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082775 · Cited by 41
Quantitative analysis of protein interaction network dynamics in yeast
Celaj, A., Schlecht, U., Smith, J., Xu, W., Suresh, S., Miranda, M., Aparicio, A. M., Proctor, M. J., Davis, R. W., Roth, F. P., et al. (2017) · Molecular Systems Biology · doi:10.15252/msb.20177532 · Cited by 40
Lipid metabolism in ferroptosis and ferroptosis-based cancer therapy
Sun, Y., Xue, Z., Huang, T., Che, X., & Wu, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.941618 · Cited by 44
Isoprenoid metabolism in the vertebrate retina
Fliesler, S. J., & Keller, R. K. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00018-6 · Cited by 41
Statins in homozygous familial hypercholesterolemia
Marais, A. D., Blom, D. J., & Firth, J. C. (2002) · Current Atherosclerosis Reports · doi:10.1007/s11883-002-0058-7 · Cited by 40
Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats
Nozaki, Y., Kumagai, K., Miyata, N., & Niwa, M. (2012) · Acta Orthopaedica · doi:10.3109/17453674.2011.641103 · Cited by 40
Regression of poloxamer 407-induced atherosclerotic lesions in C57BL/6 mice using atorvastatin
Johnston, T. P., Baker, J. C., Hall, D., Jamal, S., Palmer, W. K., & Emeson, E. E. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00339-1 · Cited by 40
Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression
Iacobazzi, V., Convertini, P., Infantino, V., Scarcia, P., Todisco, S., & Palmieri, F. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.008 · Cited by 40
Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins
Shiomi, M., Koike, T., & Ito, T. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.08.030 · Cited by 40
Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol-induced seizures
Funck, V. R., de Oliveira, C. V., Pereira, L. M., Rambo, L. M., Ribeiro, L. R., Royes, L. F. F., Ferreira, J., Guerra, G. P., Furian, A. F., Oliveira, M. S., et al. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2011.03261.x · Cited by 41
ACAT inhibitors: evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents
Roth, B. D. (1998) · Drug Discovery Today · doi:10.1016/s1359-6446(97)01123-9 · Cited by 40
Inhibition of cholesterol biosynthesis in cultured fibroblasts by D003, A mixture of very long chain saturated fatty acids
Menéndez, R., Más, R., Amor, A. M., Rodeiros, I., González, R. M. D., & Alfonso, J. L. (2001) · Pharmacological Research · doi:10.1006/phrs.2001.0851 · Cited by 40
On-Statin Cholesteryl Ester Transfer Protein Mass and Risk of Recurrent Coronary Events (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 [PROVE IT-TIMI 22] Study)
Khera, A. V., Wolfe, M. L., Cannon, C. P., Qin, J., & Rader, D. J. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.03.057 · Cited by 38
Expression of Fusion Proteins of Aspergillus terreus Reveals a Novel Allene Oxide Synthase
Hoffmann, I., Jernerén, F., & Oliw, E. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.458257 · Cited by 39
Structure Elucidation and Enantioselective Total Synthesis of the Potent HMG-CoA Reductase Inhibitor FR901512 via Catalytic Asymmetric Nozaki−Hiyama Reactions
Inoue, M., & Nakada, M. (2007) · Journal of the American Chemical Society · doi:10.1021/ja070812w · Cited by 39
Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets
Mudduluru, G., Walther, W., Kobelt, D., Dahlmann, M., Treese, C., Assaraf, Y. G., & Stein, U. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.03.002 · Cited by 37
Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives
Li, J., Cai, Z., Li, X., & Zhuang, C. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01223 · Cited by 39
Harnessing RNA Interference for Cholesterol Lowering: The Bench‐to‐Bedside Story of Inclisiran
Wilkinson, M. J., Bajaj, A., Brousseau, M. E., & Taub, P. R. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.032031 · Cited by 37
Camphene, a Plant Derived Monoterpene, Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression
Vallianou, I., & Hadzopoulou‐Cladaras, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147117 · Cited by 37
Anti-atherosclerotic activity of root bark of Premna integrifolia Linn. in high fat diet induced atherosclerosis model rats
Chitra, S., Rajakannu, A., Arunadevi, R., Gaidhani, S. N., Ilavarasan, R., & Singh, D. V. K. (2016) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2016.12.002 · Cited by 37
Increased sensitivity of multidrug-resistant myeloid leukemia cell lines to lovastatin
Maksumova, L., Ohnishi, K., Muratkhodjaev, F., Zhang, W., Pan, L., Takeshita, A., & Ohno, R. (2000) · Leukemia · doi:10.1038/sj.leu.2401856 · Cited by 37
Statin therapy is associated with a reduced risk of non-alcoholic fatty liver in overweight individuals
de Keyser, C. E., Koehler, E. M., Schouten, J. N. L., Visser, L. E., Albert Hofman, D., Janssen, H. L. A., & Stricker, B. H. C. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.04.002 · Cited by 36
Control of rumen methanogenesis by inhibiting the growth and activity of methanogens with hydroxymethylglutaryl-SCoA inhibitors
Wolin, M. J., & Miller, T. L. (2006) · International Congress Series · doi:10.1016/j.ics.2006.01.031 · Cited by 36
DFT study on hydroxy acid–lactone interconversion of statins: the case of fluvastatin
Grabarkiewicz, T., Grobelny, P. J., Hoffmann, M., & Mielcarek, J. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b612999b · Cited by 36
Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) Cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors
Contreras, L. M., Vivas, J., & Urbina, J. A. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00903-3 · Cited by 36
DFT study on hydroxy acid–lactone interconversion of statins: the case of atorvastatin
Hoffmann, M., & Nowosielski, M. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b803342k · Cited by 34
Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin
Costa, R. A. P. E., Fernandes, M. P., de Souza-Pinto, N. C., & Vercesi, A. E. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.001 · Cited by 35
Pravastatin Chronic Treatment Sensitizes Hypercholesterolemic Mice Muscle to Mitochondrial Permeability Transition: Protection by Creatine or Coenzyme Q10
Busanello, E. N. B., Marques, A. C. S., Lander, N. M., de Oliveira, D. N., Catharino, R. R., Oliveira, H. C. F., & Vercesi, A. E. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00185 · Cited by 34
Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells
Ory, B., Moriceau, G., Trichet, V., Blanchard, F., Berreur, M., Rédiní, F., Rogers, M. J., & Heymann, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00141.x · Cited by 35
Atorvastatin Reduces Postprandial Accumulation and Cholesteryl Ester Transfer Protein-Mediated Remodeling of Triglyceride-Rich Lipoprotein Subspecies in Type IIB Hyperlipidemia
Guérin, M., Egger, P., Goff, W. L., Soudant, C., Dupuis, R., & Chapman, M. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020298 · Cited by 35
A novel statin-mediated “prenylation block-and-release” assay provides insight into the membrane targeting mechanisms of small GTPases
Ali, B. R., Nouvel, I., Leung, K. F., Hume, A. N., & Seabra, M. C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.045 · Cited by 35
Coronary Heart Disease Risk Associated with Primary Isolated Hypertriglyceridemia; a Population‐Based Study
Saadatagah, S., Pasha, A. K., Alhalabi, L., Sandhyavenu, H., Farwati, M., Smith, C. Y., Wood‐Wentz, C. M., Bailey, K. R., & Kullo, I. J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019343 · Cited by 35
The Complementary Effects of Atorvastatin and Exercise Treatment on the Composition and Stability of the Atherosclerotic Plaques in ApoE Knockout Mice
Moustardas, P., Kadoglou, N. P. E., Katsimpoulas, M., Kapelouzou, A., Kostomitsopoulos, N. G., Karayannacos, P. E., Kostakis, A. I., & Liapis, C. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108240 · Cited by 34
Inhibition of proprotein convertase subtilisin/kexin type 9: A novel mechanism of berberine and 8-hydroxy dihydroberberine against hyperlipidemia
Liu, D., Xu, L., Dong, H., Chen, G., Huang, Z., Zou, X. G., Wang, K., Luo, Y.-H., & Lu, F. (2014) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-014-1775-1 · Cited by 34
Lovastatin Production by Pleurotus ostreatus: Effects of the C:N Ratio
Alarcón, J., & Águila, S. A. (2006) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2006-1-217 · Cited by 33
Current and future aspects of several adjunctive treatment strategies in polycystic ovary syndrome
Banaszewska, B., Pawelczyk, L. A., & Spaczyński, R. (2019) · Reproductive Biology · doi:10.1016/j.repbio.2019.09.006 · Cited by 33
The Emerging Role of the Gut Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives
Papadopoulos, P., Tsigalou, C., Valsamaki, P. N., Konstantinidis, T. G., Voidarou, C. C., & Bezirtzoglou, E. (2022) · Biomedicines · doi:10.3390/biomedicines10050948 · Cited by 40
2002 Alfred Burger Award Address in Medicinal Chemistry. Natural Products and Design: Interrelated Approaches in Drug Discovery
Patchett, A. A. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020424z · Cited by 33
Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9D374Y Pathway: in vitro Characterization of its Dual Hypocholesterolemic Behavior
Lammi, C., Bollati, C., Lecca, D., Abbracchio, M. P., & Arnoldi, A. (2019) · Nutrients · doi:10.3390/nu11071665 · Cited by 33
Acquired Resistance to Bisphosphonates in Paget's Disease of Bone
Papapoulos, S. E., Eekhoff, E. M. W., & Zwinderman, A. H. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.06s216 · Cited by 33
Cost-effectiveness of simvastatin in the secondary prevention of coronary artery disease in Canada.
Rivière, M., Wang, S., Leclerc, C., Fitzsimon, C., & Tretiak, R. (1997) · Europe PMC (PubMed Central) · Cited by 33
The Chemical Screening Approach
Grabley, S., Thiericke, R., & Zeeck, A. (2000) · Springer eBooks · doi:10.1007/978-3-642-60250-4_8 · Cited by 33
Benefits and Risks of Statin Therapy in the HIV-Infected Population
Mosepele, M., Molefe‐Baikai, O. J., Grinspoon, S. K., & Triant, V. A. (2018) · Current Infectious Disease Reports · doi:10.1007/s11908-018-0628-7 · Cited by 32
Statins: Complex outcomes but increasingly helpful treatment options for patients
Mohammadkhani, N., Gharbi, S., Rajani, H. F., Farzaneh, A., Mahjoob, G., Hoseinsalari, A., & Korsching, E. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172704 · Cited by 37
Atorvastatin increases expression of low‐density lipoprotein receptor mRNA in human circulating mononuclear cells
Pocathikorn, A., Taylor, R. R., & Mamotte, C. D. S. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05337.x · Cited by 32
Effects of simvastatin in abdominal sepsis in rats
Neto, J. L. D. S., Araújo-Filho, I., do Rêgo, A. C. M., Dominici, V. A., Azevedo, Í. M., do Egito, E. S. T., Brandão‐Neto, J., & Medeiros, A. C. (2006) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502006001000003 · Cited by 32
Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipients
Singer, J. B., Holdaas, H., Jardine, A. G., Fellström, B., Os, I., Bermann, G., & Meyer, J. M. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700076-jlr200 · Cited by 32
Fluvastatin Prevents Vascular Hyperplasia by Inhibiting Phenotype Modulation and Proliferation Through Extracellular Signal-Regulated Kinase 1 and 2 and p38 Mitogen-Activated Protein Kinase Inactivation in Organ-Cultured Artery
Sakamoto, K., Murata, T., Chuma, H., Hori, M., & Ozaki, H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000152611.50953.e2 · Cited by 32
Dietary bile acids promote sterol metabolism, bile acids enterohepatic circulation, and apoptosis in juvenile Pacific white shrimp (Litopenaeus vannamei)
Li, X., Li, H.-M., Qu, K., Liu, Y., Chi, S., Yang, Q., Tan, B., Zhang, S., & Xie, S. (2023) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2023.115710 · Cited by 30
Unfermented grape juice reduce genomic damage on patients undergoing hemodialysis
Corredor, Z., Rodríguez‐Ribera, L., Coll, E., Montañés, R., Díaz, J. M., Ballarín, J., Marcos, R., & Pastor, S. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.03.016 · Cited by 35
Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells
Yang, J., Wang, Y., Zhou, T., Wong, L.-Y., Tian, X.-Y., Hong, X., Lai, W., Au, K., Wei, R., Liu, Y., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.01.027 · Cited by 31
Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG‐CoA reductase
Pak, V. V., Koo, M., Kim, M. J., Yang, H. J., Yun, L. M., & Kwon, D. Y. (2008) · Journal of Molecular Recognition · doi:10.1002/jmr.889 · Cited by 31
Rosuvastatin Lowers Coenzyme Q10 Levels, but not Mitochondrial Adenosine Triphosphate Synthesis, in Children with Familial Hypercholesterolemia
Avis, H. J., Hargreaves, I., Ruiter, J. P. N., Land, J. M., Wanders, R. J. A., & Wijburg, F. A. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.08.015 · Cited by 31
An in vitro study of the effects of lovastatin on human fetal brain cells
Павлов, О. В., Bobryshev, Y. V., Balabanov, Y. V., & Ashwell, K. W. S. (1995) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(95)91641-w · Cited by 31
Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids
Thelin, A., Peterson, E., Hutson, J. L., McCarthy, A. D., Ericsson, J., & Dallner, G. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90049-3 · Cited by 31
Statins as a Novel Therapeutic Strategy in Acute Lung Injury
Singla, S., & Jacobson, J. R. (2012) · Pulmonary Circulation · doi:10.4103/2045-8932.105028 · Cited by 30
Inhibition of Rab1 GTPase and Endoplasmic Reticulum-to-Golgi Trafficking Underlies Statin’s Toxicity in Rat Skeletal Myofibers
Sakamoto, K., Wada, I., & Kimura, J. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.179762 · Cited by 30
Statin Intolerance Clinical Guide 2018
Kajinami, K., Tsukamoto, K., Koba, S., Inoue, I., Yamakawa, M., Suzuki, S., Hamano, T., Saito, H., Saito, Y., Masuda, S., et al. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.50948 · Cited by 32
Survival of the hospitalized patients with COVID‐19 receiving atorvastatin: A randomized clinical trial
Ghafoori, M., Saadati, H., Taghavi, M., Azimian, A., Alesheikh, P., Mohajerzadeh, M. S., Behnamfar, M., Pakzad, M., & Rameshrad, M. (2022) · Journal of Medical Virology · doi:10.1002/jmv.27710 · Cited by 30
Statins: A Potential Therapeutic Addition to Treatment for Aneurysmal Subarachnoid Hemorrhage?
Sabri, M., & Macdonald, R. L. (2010) · World Neurosurgery · doi:10.1016/j.wneu.2010.03.032 · Cited by 29
Myocardial infarction: a paradigm of success in modern medicine
Thiene, G., & Basso, C. (2009) · Cardiovascular Pathology · doi:10.1016/j.carpath.2009.08.002 · Cited by 30
Effects of Simvastatin on Plasma Lipids and Apolipoproteins in Familial Hypercholesterolemic Swine
Hasler‐Rapacz, J., Kempen, H. J. M., Princen, H. M. G., Kudchodkar, B. J., Lacko, A. G., & Rapacz, J. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.1.137 · Cited by 28
Role for protein geranylgeranylation in adult T-cell leukemia cell survival
Nonaka, M., Uota, S., Saitoh, Y., Takahashi, M. M., Sugimoto, H., Amet, T., Arai, A., Miura, O., Yamamoto, N., & Yamaoka, S. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.10.010 · Cited by 29
Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus
Kajinami, K., & Yasusyuki, K. (2011) · Drug Design Development and Therapy · doi:10.2147/dddt.s13492 · Cited by 28
Prescription of statins in suspected non‐alcoholic fatty liver disease and high cardiovascular risk, a population‐based study
van den Berg, E. H., Wolters, A. A. B., Dullaart, R. P. F., Moshage, H. J., Zurakowski, D., de Meijer, V. E., & Blokzijl, H. (2019) · Liver International · doi:10.1111/liv.14116 · Cited by 28
A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study
Guerrero-Bonmatty, R., Fernández, G. G., Rodríguez-Velasco, F. J., & Espadaler, J. (2021) · Nutrients · doi:10.3390/nu13041206 · Cited by 30
Exploration of Virtual Candidates for Human HMG-CoA Reductase Inhibitors Using Pharmacophore Modeling and Molecular Dynamics Simulations
Son, M., Baek, A., Sakkiah, S., Park, C., John, S., & Lee, K. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083496 · Cited by 30
Statins lower calcium-induced oxidative stress in isolated mitochondria
Parihar, A., Parihar, M. S., Zenebe, W., & Ghafourifar, P. (2011) · Human & Experimental Toxicology · doi:10.1177/0960327111429141 · Cited by 28
Sterol Carrier Protein 2, a Critical Host Factor for Dengue Virus Infection, Alters the Cholesterol Distribution in Mosquito Aag2 Cells
Fu, Q., İnankur, B., Yin, J., Striker, R., & Lan, Q. (2015) · Journal of Medical Entomology · doi:10.1093/jme/tjv101 · Cited by 28
Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD
Price, K. E., Armstrong, C. M., Imlay, L. S., Hodge, D. M., Pidathala, C., Roberts, N. J., Park, J., Mikati, M. O., Sharma, R., Lawrenson, A. S., et al. (2016) · Scientific Reports · doi:10.1038/srep36777 · Cited by 28
Geranylgeraniol Prevents Statin‐Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy
Jaśkiewicz, A., Pająk, B., Litwiniuk, A., Urbańska, K., & Orzechowski, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6463807 · Cited by 28
National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2015) · Cited by 27
The total synthesis of calcium atorvastatin
Dias, L. C., Vieira, A. S., & Barreiro, E. J. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob02546j · Cited by 27
Simvastatin inhibits protein isoprenylation in the brain
Ostrowski, S. M., Johnson, K., Siefert, M. E., Shank, S. S., Sironi, L., Wolozin, B. L., Landreth, G. E., & Ziady, A. G. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.053 · Cited by 28
Studies on the regulation of lipid metabolism and its mechanism of the iridoids rich fraction in Valeriana jatamansi Jones
Zhu, J., Xu, K., Zhang, X., Cao, J., Jia, Z., Yang, R., Ma, C., Chen, C., Zhang, T., & Yan, Z. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.099 · Cited by 27

Authors: Endo, A.
Corresponding author: Endo, A
ORCID: Endo, A
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1992-11
Volume: 33
Issue: 11
Pages: 1569-1582
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)41379-3
OpenAlex: W2148463229
Cited by: 847
References: 114
Citations by year: 2026: 11 · 2025: 19 · 2024: 31 · 2023: 22 · 2022: 25 · 2021: 26 · 2020: 23 · 2019: 20 · 2018: 35 · 2017: 28 · 2016: 37 · 2015: 41 · 2014: 39 · 2013: 43 · 2012: 35
FWCI: 16.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10200 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
Keywords: statins, cholesterol-lowering drugs, drug discovery, drug development
MeSH terms: Animals, Anticholesteremic Agents, Humans, Hypercholesterolemia, Lovastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, History, 20th Century

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The discovery and development of HMG-CoA reductase inhibitors.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks