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The discovery and development of HMG-CoA reductase inhibitors.
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During the 1950s and 1960s, many cholesterol-lowering agents were reported and introduced into clinical use, in-
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“Nonetheless, TGs have been demonstrated to be correlated with acute pancreatitis655).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [655]
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Sorted by citations
Triglycerides and cardiovascular disease
Nordestgaard, B. G., & Varbo, A. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61177-6 · Cited by 1,419
The role of natural product chemistry in drug discovery
Butler, M. S. (2004) · Journal of Natural Products · doi:10.1021/np040106y · Cited by 1,381
Nordestgaard, B. G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306249 · Cited by 1,116
Natural products to drugs: natural product-derived compounds in clinical trials
Butler, M. S. (2008) · Natural Product Reports · doi:10.1039/b514294f · Cited by 1,086
A Tale of Coronary Artery Disease and Myocardial Infarction
Nabel, E. G., & Braunwald, E. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1112570 · Cited by 1,024
Metadata
- Authors
- Endo, A.
- Corresponding author
- Endo, A
- ORCID
- Endo, A
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 33
- Issue
- 11
- Pages
- 1569-1582
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2148463229
- Cited by
- 847
- References
- 114
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 31 · 2023: 22 · 2022: 25 · 2021: 26 · 2020: 23 · 2019: 20 · 2018: 35 · 2017: 28 · 2016: 37 · 2015: 41 · 2014: 39 · 2013: 43 · 2012: 35
- FWCI
- 16.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Keywords
- statins, cholesterol-lowering drugs, drug discovery, drug development
- MeSH terms
- Animals, Anticholesteremic Agents, Humans, Hypercholesterolemia, Lovastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, History, 20th Century
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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