The discovery and development of HMG-CoA reductase inhibitors.

Regulation of the mevalonate pathway

Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394

Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B

Brown, G., Albers, J. J., Fisher, L. D., Schaefer, S. M., Lin, J.-T., Kaplan, C., Zhao, X.-Q., Bisson, B. D., Fitzpatrick, V. F., & Dodge, H. T. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011083231901 · Cited by 2,159

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 1,906

All ras proteins are polyisoprenylated but only some are palmitoylated

Hancock, J. F., Magee, A. I., Childs, J. E., & Marshall, C. J. (1989) · Cell · doi:10.1016/0092-8674(89)90054-8 · Cited by 1,775

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Alberts, A. W., Chen, J., Kuron, G. W., Hunt, V. M., Huff, J. W., Hoffman, C., Rothrock, J. W., López, M., Joshua, H., Harris, E., et al. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.3957 · Cited by 1,630

Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease.

(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-5-786_2 · Cited by 1,426

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

Endo, A., KURODA, M., & Tsujita, Y. (1976) · The Journal of Antibiotics · doi:10.7164/antibiotics.29.1346 · Cited by 954

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

Endo, A., Kuroda, M., & Tanzawa, K. (1976) · FEBS Letters · doi:10.1016/0014-5793(76)80996-9 · Cited by 800

HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia

Oates, J. A., Wood, A. J. J., & Grundy, S. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807073190105 · Cited by 760

Influence of nicotinic acid on serum cholesterol in man

Altschul, R., Hoffer, A., & Stephen, J. D. (1955) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(55)90070-9 · Cited by 726

Microbial Natural Products: Chemical Diversity

Sánchez, S., Guzmán‐Trampe, S., Ávalos, M., Ruiz‐Villafán, B., Rodrı́guez-Sanoja, R., & Jiménez‐Estrada, M. (2012) · Wiley Encyclopedia of Chemical Biology · doi:10.1002/9780470048672.wecb721 · Cited by 1

Las vastatinas, inhibidoras de la biosíntesis del colesterol: eficacia y toxicidad

Asenjo-Barrón, J. C., Zagoya, J. C. D., Juárez-Oropeza, M. A., Zamora, R. M., & Huerta, M. Á. P. (2001) · Cited by 1

The statins: a drug class to celebrate

Betteridge, J. D. (2010) · Trends in Urology & Men s Health · doi:10.1002/tre.157 · Cited by 1

Die Geschichte der Therapie von Fettstoffwechselstörungen. Verhältnismäßig kurz und spannend

Bernschneider‐Reif, S. (2007) · Pharmazie in unserer Zeit · doi:10.1002/pauz.200600206 · Cited by 1

Synthesis and structure–activity relationships of N-(4-amino-2,6-diisopropylphenyl)-N’-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents

Asano, S., Ban, H., Kino, K., Ioriya, K., & Muraoka, M. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.04.059 · Cited by 1

Deviation Among Technology Reviews: An Informative Enrichment of Technology Evolution Theory for Marketing

Sood, A., & Stremersch, S. (2010) · RePub (Erasmus University Rotterdam) · Cited by 1

Efectos de pravastatina en la disfunción endotelial, estrés oxidativo y otros parámetros cardiovasculares

Kassan, M. (2010) · doi:10.14201/gredos.83206 · Cited by 1

Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts

Jurkowski, I. (2010) · doi:10.21007/etd.cghs.2010.0157 · Cited by 1

The Effect of Bupleuri Radix Herbal-acupuncture at GB34(Yangneungcheon) on Hyperlipidemia in Rats

Park, J.-Y., & Song, C.-H. (2010) · Korean Journal of Acupuncture · Cited by 1

The Effects of Statin and Fibrate Drugs on Cholesterol Metabolism and Steroid Production in Two Fish Species

Al-Habsi, A. A. (2014) · uO Research (University of Ottawa) · doi:10.20381/ruor-6632 · Cited by 1

New mechanisms by which statins lower plasma cholesterol

Brunengraber, H. (2016) · Journal of Lipid Research · doi:10.1194/jlr.c070417 · Cited by 1

Drugs, Nutrients, and Hormones in Mitochondrial Function

Berdanier, C. D. (2005) · CRC Press eBooks · doi:10.1201/9781420028843-14 · Cited by 2

Does Atorvastatin Help Prevent Classic Migraine Attacks? A Triple-Blind Controlled Clinical TrialPreprint

Ganji, R., Majdinasab, N., Hesam, S., Rostami, N., Sayyah, M., & Sahebnasagh, A. (2020) · doi:10.21203/rs.3.rs-18477/v1 · Cited by 1

Eugene Braunwald 心臓学における20世紀の10大業績

章, 遠. (2008) · 心臓 · doi:10.11281/shinzo1969.40.11_1027 · Cited by 1

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Osnes, J., Andressen, K. W., & Levy, F. O. (2024) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.24.0165 · Cited by 1

In-silico screening of potential inhibitors of HMGCoA reductase and Lanosterol synthase, key enzymes in cholesterol biosynthesis pathway

Chandra, N. S. V. S. (2014)

Lipid Lowering Drugs and the Arterial Wall

Paoletti, R., Bernini, F., Corsini, A., & Soma, M. R. (1998) · Medical science symposia series · doi:10.1007/978-94-011-5022-4_3

Drug Development for Metabolic Diseases: Past, Present and Future

Wang, M. (2011) · Wiley eBooks · doi:10.1002/9780470910016.ch18

Cholesterol Disturbances in Inherited Neurodegenerative Diseases : Studies on Npc1, Ppt1 and Ctsd deficient mice

Mutka, A. (2009) · Työväentutkimus Vuosikirja

From the Editor: The Akira Endo Award

Brown, W. V. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.06.003

Introduction to Randomized Clinical Trials in Cardiovascular Disease

Geisler, T., Flather, M., Bhatt, D. L., & D'Agostino, R. (2012) · doi:10.1002/9781118399378.ch1

The Economics of a New Health Technology: An Evaluation of the Impact of Statins on Lifestyle Behaviors

Dehmer, S. P. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)

Systemic medications and other risk factors of open-angle glaucoma

Marcus, M. W. (2012) · University of Groningen research database (University of Groningen / Centre for Information Technology)

Efeito da sinvastatina, alfa-tocoferol e L-arginina sobre os inibidores endógenos da óxido nítrico sintase, metabólitos do óxido nítrico e tióis em pacientes hipercolesterolêmicos

Pereira, E. C. (2002) · doi:10.11606/d.9.2002.tde-03052010-162703

Adaptive immune responses in atherosclerosis - or how to prolong the use of your yellow socks

Kolbus, D. (2011) · Lund University Publications (Lund University)

Effect of pre-treatment with simvastatin in aged rats with abdominal sepsis

Medeiros, A. C., Costa, M. C., Calife, E. R., da Costa, M. S. T., do Rêgo, A. C. M., Medeiros, V. B., Araújo-Filho, I., & Carvalho, M. D. F. (2014) · JOURNAL OF SURGICAL AND CLINICAL RESEARCH · doi:10.20398/jscr.v5i1.5670

A 4-year trial of simvastatin in the treatment of patients with heterozygous familial hypercholesterolemia

Kitatani, M., Koizumi, J., Inazu, A., Kajinami, K., & Mabuchi, H. (1996) · Current Therapeutic Research · doi:10.1016/s0011-393x(96)80031-2

How Much Do We Really Know About Statins and Transplant Vasculopathy?

Harken, A. H. (2014) · World Journal of Surgery · doi:10.1007/s00268-014-2623-y

Conformational analysis of yvae peptide derivatives

Pak, V. V., Kwon, D. Y., Yun, L. M., Yili, A., Aisa, H. A., & Shakhidoyatov, K. М. (2012) · Chemistry of Natural Compounds · doi:10.1007/s10600-012-0399-6

Enhancement of low density lipoprotein binding to both low density lipoprotein receptor‐positive and‐ negative cells by tetracycline antibiotics

Miura, S., Hasumi, K., Takayasu, R., Sugimoto, M., & Endo, A. (1998) · Lipids · doi:10.1007/s11745-998-0177-y

Statins have offered great benefits

Yamamoto, A. (2004) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2004.08.017

Cardiac motion analysis of a rat model for myocardial infarction using high-frame-rate stereo images

Ishii, I., Okuda, T., Nie, Y., Takaki, T., Orito, K., Tanaka, A., & Matsuda, H. (2010) · IEEE International Conference on Automation Science and Engineering (CASE) · doi:10.1109/coase.2010.5584712

Estatinas, uso racional en el tratamiento de la dislipoproteinemia

Ferrer, J. I. (2009) · Revista cubana de medicina general integral

Identification of thirteen up-expressed sequence tags from Monascus pilosus mutant MK-1

Zhang, M. (2011) · African Journal of Microbiology Research · doi:10.5897/ajmr11.701

STUDIES ON THE REGULATORY ROLES OF CHOLESTEROL AND BILE ACIDS

Murphy, C. (2007) · Figshare

3-Hydroxy-3-Methylglutaryl-CoenzymeAReductase InhibitorsAttenuate-Amyloid-InducedMicroglial InflammatoryResponses

Landreth, G. E. (2005)

Original article Cost-effectiveness analysis of rosuvastatin vs generic atorvastatin in Spain

Barrios, V., Serrano, A., Brosa, M., & Capel, M. (2012)

Pharmacokinetics, efficacy, and safety of pravastatin in children

Koskinen, M. (2006)

Cholesterol Disturbances in Inherited Neurodegenerative Diseases

Mutka, A. (2009)

A PHARMACODYNAMIC INTERACTIVE STUDY OF ATORVASTATIN AND GARLIC IN TREATMENT OF DYSLIPIDAEMIAS IN RATS.

Reddy, G. D., & Reddy, A. G. (2013) · International Journal of Pharma and Bio Sciences

Statins: in the beginning

Cardiologist, C. (2009)

Modeling an Active Peptide Conformation and Design a Competitive Inhibitory Peptide for HMG-CoA Reductase

Pak, V. V., Shin, V. N., & Yun, L. M. (2011) · Springer proceedings in physics · doi:10.1007/978-3-642-17913-6_16

PLEIOTROPIC MECHANISMS OF STATIN ACTION IN ALZHEIMER'S DISEASE

Ostrowski, S. M. (2008) · OhioLink ETD Center (Ohio Library and Information Network)

Genetics of Common Lipid Disorders

Nock, N. L. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_12-1

Comparação do Efeito de Dois Inibidores da HMG CoA Redutase sobre a Suscetibilidade da LDL à Oxidação

Portal, V. L., Moriguchi, E. H., Mastalir, E. T., Bortolini, E. B., Rodrigues, R., & Alegre, P. (2003)

Desenvolvimento e validação da metodologia analítica do teor de atorvastatina cálcica em insumo farmacêutico ativo e em comprimidos por cromatografia líquida de alta eficiência

Nunes, N. M. (2010) · Americanae (AECID Library)

Cardiac Motion Analysis Using High-Speed Video Images in a Rat Model for Myocardial Infarction

Ishii, I., Okuda, T., Nie, Y., Takaki, T., Orito, K., Tanaka, A., & Matsuda, H. (2010) · Transactions of the Society of Instrument and Control Engineers · doi:10.9746/sicetr.46.547

Cerebral Vasospasm

Li, Y., Cıkla, U., Mamadov, J., Hanna, R. B., & Başkaya, M. K. (2015) · Contemporary Neurosurgery · doi:10.1097/01.cne.0000471970.23809.30

Statin medication adherence and associated outcomes in type 2 diabetes medicaid enrollees with comorbid hyperlipidemia.

Wu, J. (2010) · OhioLink ETD Center (Ohio Library and Information Network)

CardioPulse Articles

Görenek, B. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu261

Winds of change: growing demands for transparency in the relationship between doctors and the pharmaceutical industry

Barnes, R. (2010) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2010.tb03519.x

Cardiology--a saga of one hundred years "but, where is the conductor?"--Braunwald, 2003.

Misra, K. P., & Sridharan, S. (2005) · PubMed

Farmakoloske, toksikoloske i biohemijske osobine preparata gljive Coprinus comatus

Stilinović, N. (2013) · doi:10.2298/ns20131230stilinovic

Statiner hemmer aktivitet av den lysosomale cysteinproteasen legumain -Spiller legumain en rolle i apoptose?

Yaseen, I. M. (2011) · NORA - Norwegian Open Research Archives

Pharmacological Treatments of Lipid Abnormalities

Navare, S. M., & Thompson, P. D. (2005) · CRC Press eBooks · doi:10.1201/9781420038422.ch10

Impact of Medical Therapy on Cardiovascular Secondary Prevention

Nieva, R., Achtchi, A., Eapen, D. J., Dollar, A. L., Baer, J., Mavromatis, K., & Sperling, L. S. (2013) · CRC Press eBooks · doi:10.1201/b13781-102

AKIRA ENDO: THE DISCOVERY OF STATINS

Thompson, G. R., & Mabuchi, H. (2014) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781783263851_0015

Studies on lipoprotein kinetics in obesity and the metabolic syndrome: impact of dietary weight loss and statin therapy

Ng, T. (2007) · UWA Profiles and Research Repository (UWA)

Statins, Inflammation, and Cardiomyopathy: Old Pathways, New Targets

Lowenstein, C. J., & Yamakuchi, M. (2006) · Fundamental and clinical cardiology · doi:10.3109/9781420020168.009

The statins: a drug class

Betteridge, J. D. (2010)

Bacterial translocation in rats treated with simvastatin undergoing intestinal ischemia and reperfusion. Translocação bacteriana em Ratos tratados com sinvastatina submetidos a isquemia intestinal e reperfusão.

Azevedo, Í. M., Araújo-Filho, I., Cínthia, A., Medeiros, V. B., Carvalho, M. D. F., Egito, S. T., & Medeiros, A. C. (2010)

Statin mediated vasodilation in the vasculature.

Copley, S. (2011) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

Analysis of liver X receptor target gene expression across species

Noto, P. B., & Bentz, J. E. (2013) · iDEA - Drexel University Institutional Repository · doi:10.17918/etd-4198

The role of Hedgehog acyltransferase in Sonic hedgehog signalling

Jovanović, B. (2012) · Spiral (Imperial College London) · doi:10.25560/14486

FARMAKOLOŠKE, TOKSIKOLOŠKE I BIOHEMIJSKE OSOBINE PREPARATA GLJIVE COPRINUS COMATUS

Fakultet, M. (2013)

The ESCAPE randomized clinical trial: 20-80 mg of Zokor (Simvastatin) in patients with familial hypercholesterolemia in ischemia heart disease. Part 1. Hypolipidemic efficacy, safety and tolerance

Sussekov, A. V., Zubareva, M. Y., Ta, R., Бадриевна, Г. Н., Solov’eva, E. Y., Balakhonova, T. V., Кулев, Б. Д., Погорелова, О. А., Рогоза, А. Н., Бойцов, С. А., et al. (2009) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2009-15-5-543-549

Drugs development and fragile X syndrome translational success story

Budimirovic, D. B., & Protic, D. D. (2016) · Medicinski podmladak · doi:10.5937/mp67-12697

Revisión Efectos no hipolipemiantes de las estatinas

Ramos-Esquivel, A., & León-Céspedes, C. (2007)

Development of a high throughput small molecule screen using Staphylococcus aureus invasion of cells

Kenney, S. R. (2009) · Cardinal Scholar (Ball State University)

The effect of acute simvastatin administration on the ischaemia and reperfusion-induced ventricular arrhythmias in anesthetized dogs

Kisvári, G. (2016) · doi:10.14232/phd.3162

Staphylococcus aureus stimulates the release of constitutive tissue factor in lung epithelial cells

DeWalt, R. I. (2011) · Cardinal Scholar (Ball State University)

Einfluss perioperativer Statintherapie auf die postoperative Hämodynamik nach herzchirurgischen Operationen mit Herz-Lungenmaschine

Gehoff, P. (2011) · doi:10.53846/goediss-1048

Understanding the Regulation of HMGCR

Hassanabad, A. F. (2013) · Library and Archives Canada (Government of Canada)

Anti-hyperlipidemic Effect of Insamsansa-eum in Mice

Sang-Hyun, J., Ko, C., Bae, H.-S., Kim, Y. S., Cho, K., Min, S., & Kim, D. (2008) · Natural Product Sciences

Lysosomal oxidation of Low Density Lipoproteins

Ahmad, F. (2017) · CentAUR (University of Reading)

Konrad Bloch, PhD

Pendse, A. A., Lockyer, P. P., Schisler, J. C., & Willis, M. S. (2011) · Laboratory Medicine · doi:10.1309/lm3ycf1i6ccbbzjor

Avaliação de biodisponibilidade e mecanismos de ação hipocolesterolemizante de peptídeos do amaranto (Amaranthus cruentus L. BRS-Alegria)

Freitas, R. A. M. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.6.2018.tde-23012018-170719

Structural, functional and inhibition studies of human histone deacetylase 7

Desravines, D. C. (2010) · HAL

Effect of Statins Beyond Lowering Cholesterol: Where Do We Stand?

Quarato, P., Ferri, N., Arnaboldi, L., Fumagalli, R., Paoletti, R., & Corsini, A. (1998) · Medical science symposia series · doi:10.1007/978-94-011-5022-4_30

Natural Product Synthesis for Drug Discovery and Chemical Biology

Yao, Z., & Wei, W. (2018) · doi:10.1002/9781118940228.ch10

Investigations of Fungal Highly Reducing Polyketide Synthases: The Biosyntheses of Lovastatin and Hypothemycin

Norquay, A. K. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3v40kc7b

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Gupta, R., Sharma, S., Kaur, R., & Upadhyaya, K. (2018) · Pharmacy & Pharmacology International Journal · doi:10.15406/ppij.2018.06.00214

Organization and Management of Animal Experiments

Liu, E., & Fan, J. (2017) · CRC Press eBooks · doi:10.1201/9781315368993-8

From the editor: Lessons from the East

Guyton, J. R. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2018.11.001

Biodistribuição do pertecnetato de sódio após desvio gástrico em Y de Roux (técnica de capella)

do Rêgo, A. C. M. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Fungi as saprotrophs, symbionts and pathogens

Moore, D., Robson, G. D., & Trinci, A. P. J. (2000)

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Vlăsceanu, G. (2020) · Farmacist ro · doi:10.26416/farm.195.4.2020.3730

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Gülcan, H. O., & Orhan, İ. E. (2020) · Letters in Drug Design & Discovery · doi:10.2174/1570180817999201016154400

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Yaman, A., & Yaman, H. (2021) · Springer eBooks · doi:10.1007/978-3-319-56015-1_422-1

The Effect of morelloflavone on HMG-CoA reductase activity

Tuansulong, K. (2009) · PSU Knowledge Bank (Prince of Songkla University)

Cross-platform Screening for Novel Fluvastatin and Kinase Inhibitor Co-therapies in Cancer Cell Lines

Pong, J. T. (2014) · TSpace (University of Toronto)

Potential drug interactions with garlic

Pereverzev, A. P., & Ostroumova, O. D. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-29-47-51

What Does Fat Do?

Denton, N. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198865278.003.0003

References

(2002) · Circulation · doi:10.1161/circ.106.25.3373

Papel de las Especies Reactivas de Oxígeno en la biosíntesis de Penicilina G, Cefalosporina C y Lovastatina

León, M. E. B. (2021) · doi:10.24275/uami.pg15bf11c

Statins

Wilson, P. W. F. (2008) · Wiley Encyclopedia of Clinical Trials · doi:10.1002/9780471462422.eoct527

Faculty Opinions recommendation of Statin use and prognosis in patients with diffuse large B-cell lymphoma and follicular lymphoma in the rituximab era.

Ghesquières, H. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1540957.1030056

Compactin

Valentovic, M. A. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.61508-9

Pleiotrope Statineffekte

Rutishauser, J. (2008) · Swiss Medical Forum ‒ Schweizerisches Medizin-Forum · doi:10.4414/smf.2008.06430

Science Rewritten to Accommodate its Origin

Deans, M. T. (2016) · International Journal of Innovative Research in Medical Science · doi:10.23958/ijirms/vol01-i05/06

Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

Tobert, J. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1112 · Cited by 896

HMG-CoA reductase inhibitors as potent cholesterol lowering drugs

Tsujita, Y. (1994) · Gordon and Breach Science Publishers eBooks · Cited by 2

Lipid-lowering drugs: discovery and development of HMG-CoA reductase inhibitors.

Tsujita, Y. (1995) · 生体の科学

HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia

Oates, J. A., Wood, A. J. J., & Grundy, S. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807073190105 · Cited by 760

The discovery of the HMG-CoA reductase inhibitors “statins”: A historical perspective

Endo, A. (2001) · The Journal of Japan Atherosclerosis Society · doi:10.5551/jat1973.28.6_111