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The discovery and development of HMG-CoA reductase inhibitors.
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During the 1950s and 1960s, many cholesterol-lowering agents were reported and introduced into clinical use, in-
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“Nonetheless, TGs have been demonstrated to be correlated with acute pancreatitis655).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [655]
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Marcus, M. W., Müskens, R. P. H. M., Ramdas, W. D., Wolfs, R. C. W., de Jong, P. T. V. M., Vingerling, J. R., Albert Hofman, D., Stricker, B. H. C., & Jansonius, N. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029724 · Cited by 85
Reducing shell egg cholesterol content. I. Overview, genetic approaches, and nutritional strategies
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Tabernero, L., Bochar, D. A., Rodwell, V. W., & Stauffacher, C. V. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7167 · Cited by 85
Metadata
- Authors
- Endo, A.
- Corresponding author
- Endo, A
- ORCID
- Endo, A
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 33
- Issue
- 11
- Pages
- 1569-1582
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2148463229
- Cited by
- 847
- References
- 114
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 31 · 2023: 22 · 2022: 25 · 2021: 26 · 2020: 23 · 2019: 20 · 2018: 35 · 2017: 28 · 2016: 37 · 2015: 41 · 2014: 39 · 2013: 43 · 2012: 35
- FWCI
- 16.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Keywords
- statins, cholesterol-lowering drugs, drug discovery, drug development
- MeSH terms
- Animals, Anticholesteremic Agents, Humans, Hypercholesterolemia, Lovastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, History, 20th Century
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