Cited by 1,126melanin and skin pigmentationParkinson's Disease Mechanisms and TreatmentsBioactive Compounds and Antitumor Agents

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Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

GRAHAM, DOYLE G.·1978·Molecular Pharmacology

DOI 10.1016/s0026-895x(25)13535-9

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“It was demonstrated that DA-quinones covalently bind to thiol groups in proteins, oxidizing it [33, 34].”
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“Catecholamines are probably associated with the production of free radicals and conditions causing increased catecholamine metabolism may increase the free radical burden (Graham 1978).”
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“neuromelanin appears to be formed via a slow, nonenzymatic process based on the autoxidation and spontaneous polymerization of the catecholamine DA (Graham, 1978).”
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“Moreover, L-DOPA toxicity is correlated with high extracellular levels of quinone oxyradical L-DOPA derivatives (Graham, 1978; Mena et al., 1992; Basma et al., 1995).”
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“MA acts indirectly on the symphathomimetic system, causing a massive release of dopamine in the brain, while simultaneously preventing dopamine degradation by inhibiting monoamine oxidase activity and dopamine uptake (Golembiowska and Zylewska, 1998; Graham, 1978).”
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“In addition, MT-1 binds DA quinone, a dopaminergic neuron-specific oxidative stress product formed by DA oxidation, and can protect dopaminergic neurons against DA quinone neurotoxicity (Asanuma et al., 2003; Graham, 1978; Hastings et al., 1996; Miyazaki et al., 2007; Rabinovic and Hastings, 1998).”
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“Although the accumulation of DOPA after NSD 1015 can lead to cytotoxic DOPA quinones that, in turn, damage 5-HT terminals (Graham, 1978), the metabolism of DA by MAO-B appears important.”
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“Some authors explained that the free radical production might be related to the excess metabolism of dopamine (Graham, 1978, 1979).”
Background

Authors: GRAHAM, D. G.
Affiliations: Duke Medical Center (US)
Corresponding author: GRAHAM, DOYLE G.
Venue: Molecular Pharmacology
Publisher: Elsevier BV
Published: 1978-07
Volume: 14
Issue: 4
Pages: 633-643
ISSN: 0026-895X (ISSN-L)
DOI: 10.1016/s0026-895x(25)13535-9
OpenAlex: W2211987820
Cited by: 1,126
References: 0
Citations by year: 2026: 11 · 2025: 12 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 23 · 2019: 26 · 2018: 29 · 2017: 30 · 2016: 26 · 2015: 29 · 2014: 26 · 2013: 26 · 2012: 49
FWCI: 1.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: catecholamines, autoxidation, periodate oxidation, 6-hydroxydopamine, dopamine, norepinephrine, epinephrine, aminochrome, adrenochrome, o-quinones, p-quinones, cyclization, tautomerism, neuromelanin
MeSH terms: Catecholamines, Dopamine, Epinephrine, Hydroxydopamines, Melanins, Norepinephrine, Oxidation-Reduction, Quinones, Monophenol Monooxygenase

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Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

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