Cited by 1,126melanin and skin pigmentationParkinson's Disease Mechanisms and TreatmentsBioactive Compounds and Antitumor Agents

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Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

GRAHAM, DOYLE G.·1978·Molecular Pharmacology

DOI 10.1016/s0026-895x(25)13535-9

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“dopamine neurotoxicity in the CPu (Graham, 1978; O’Dell et al., 1991; Seiden and Sabol, 1995; Stokes t al., 1999; Yamamoto and Zhu, 1998).”
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Background
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“Dopamine has been reported to be oxidized enzymaticaly and nonenzymaticaly to aminochrome in two steps (14-21); first to dopamine o-quinone and then to aminochrome via cyclization of a free amino group.”
Background
Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson’s disease
Paris, I. B., Cárdenas, S., Lozano, J., Perez-Pastene, C., Graumann, R., Chávez‐Riveros, A., Caviedes, P. A., & Segura‐Aguilar, J. (2007) · Neurotoxicity Research · doi:10.1007/bf03033921 · Cited by 31
“Oxidation o dopamine to aminochrome is also catalyzed by enzymes (prostaglandin H synthase, cytochrome P450 forms, xanthine oxidase, and tyrosinase, dopamine -monooxygenase) or transitions metals (Hawley et al., 1967; Graham, 1978; SeguraAguilar and Lind, 1989; Hastings, 1995; SeguraAguilar, 1996; Foppoli et al., 1997…”
Method
RETRACTED: Melatonin prevents lipopolysaccharide‐induced hyporeactivity in rat
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“…result from inhibition of VMAT, which leads to sustained elevations in unsequestered DA that, in turn, can lead to increased oxidative stress (Graham, 1978; Hastings, 1995; Fahn and Cohen, 1992; Lee and Opanashuk, 2004) due either to non-enzymatic oxidation by molecular oxygen to form H2O2…”
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The effect of age on the activity of enzymes of peroxide metabolism in rat brain
Vertechy, M., Cooper, M. B., Ghirardi, O., & Ramacci, M. T. (1993) · Experimental Gerontology · doi:10.1016/0531-5565(93)90022-6 · Cited by 31
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Interactions of the 1-methyl-4-phenyl-2, 3-dihydropyridinium species with synthetic dopamine-melanin
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“Lastly, the substantia nigra in rodents and primates differ, markedly in the concentration of neuromelanin, a by-product of catecholamine auto-oxidation (DAmato et al, 1986; Graham, 1978; Graham et al., 1978; Snyder and D’Amato, 1986).”
Background
Glutathione (GSH) conjugates with dopamine (DA)-derived quinones to form reactive or non-reactive GSH-conjugatesPreprint
Zhou, Z., & Lim, T. M. (2009) · Nature Precedings · doi:10.1007/s11064-010-0247-7 · Cited by 30
Synthesis, Follow-Up, and Characterization of Polydopamine-like Coatings Departing from Micromolar Dopamine- o -Quinone Precursor Concentrations
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Liddell, J. R., Obando, D., Liu, J., Ganio, G., Volitakis, I., Mok, S. S., Crouch, P. J., White, A. R., & Codd, R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.027 · Cited by 30
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Background
N-Acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice
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Background
Does Levodopa Accelerate Parkinson??s Disease?
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The potential use of vitamin E and selenium in Parkinsonism
Cadet, J. L. (1986) · Medical Hypotheses · doi:10.1016/0306-9877(86)90089-7 · Cited by 30
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Authors: GRAHAM, D. G.
Affiliations: Duke Medical Center (US)
Corresponding author: GRAHAM, DOYLE G.
Venue: Molecular Pharmacology
Publisher: Elsevier BV
Published: 1978-07
Volume: 14
Issue: 4
Pages: 633-643
ISSN: 0026-895X (ISSN-L)
DOI: 10.1016/s0026-895x(25)13535-9
OpenAlex: W2211987820
Cited by: 1,126
References: 0
Citations by year: 2026: 11 · 2025: 12 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 23 · 2019: 26 · 2018: 29 · 2017: 30 · 2016: 26 · 2015: 29 · 2014: 26 · 2013: 26 · 2012: 49
FWCI: 1.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: catecholamines, autoxidation, periodate oxidation, 6-hydroxydopamine, dopamine, norepinephrine, epinephrine, aminochrome, adrenochrome, o-quinones, p-quinones, cyclization, tautomerism, neuromelanin
MeSH terms: Catecholamines, Dopamine, Epinephrine, Hydroxydopamines, Melanins, Norepinephrine, Oxidation-Reduction, Quinones, Monophenol Monooxygenase

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Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

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