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Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

GRAHAM, DOYLE G.·1978·Molecular Pharmacology

DOI 10.1016/s0026-895x(25)13535-9

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Background
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Takeshima, M., Murata, M., Urasoe, N., Murakami, S., Miyazaki, I., Asanuma, M., & Kita, T. (2011) · Neurological Research · doi:10.1179/1743132811y.0000000032 · Cited by 14
Growth inhibition and biodegradation of catecholamines in the ciliated protozoanTetrahymena pyriformis
Ud‐Daula, A., Pfister, G., & Schramm, K. (2008) · Journal of Environmental Science and Health Part A · doi:10.1080/10934520802329885 · Cited by 14
“There are many investigation reported that due to the unstable nature of catechol ring, it could be spontaneously oxidised and converted into quinone and the reaction is accelerated in presence of manganese or iron ions.[17,22,23] Its degradation occurred in the 96-well plate with PPY medium and Tetrahymena culture se…”
Background
Dopamine D1-Like Receptors Depress Excitatory Synaptic Transmissions in Striatal Neurons After Transient Forebrain Ischemia
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Age Pigments in Different Populations of Peripheral Neurons in Vivo and in Vitro
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Oxidative ring-coupling of tyrosine and its derivatives by purified rat intestinal peroxidase
Valoti, M., Tipton, K. F., & Sgaragli, G. P. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90597-c · Cited by 14
Catechol-O-Methyltransferase Decreases Levodopa Toxicity In Vitro
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The role of myeloperoxidase in the oxidation of biologically active polyhydroxyphenols (substituted catechols)
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MPTP-Induced Parkinsonian Syndromes in Humans and Animals
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Neurotoxic Phenylalkylamines and Indolealkylamines
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Dopamine inhibits the expression of proinflammatory cytokines of microglial cells through the formation of dopamine quinone in the mouse striatum
Yoshioka, Y., Sugino, Y., Yamamuro, A., Ishimaru, Y., & Maeda, S. (2021) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2021.10.004 · Cited by 13
Direct intranigral injection of dopaminochrome causes degeneration of dopamine neurons
Touchette, J. C., Breckenridge, J. M., Wilken, G. H., & Macarthur, H. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.028 · Cited by 13
Light modulates Drosophila lifespan via perceptual systems independent of circadian rhythms
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“Bright light exposure has been shown to induce neurodegeneration and reduce dopamine levels in the mouse and rat substantia nigra [20, 21] potentially by oxidation and generation of cytotoxic byproducts [22].”
La atorvastatina protege las neuronas GABAérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas
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Mitochondrial Stress-Induced Dopamine Efflux and Neuronal Damage by Malonate Involves the Dopamine Transporter
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“Moreover, exogenously applied DA can be toxic in vitro and in vivo (Graham, 1978; Michel and Hefti, 1990; Filloux and Townsend, 1993; McLaughlin et al., 1998a), and results in free and protein-bound cysteinyl DA formation (Hastings et al.”
Background
Oxidative damage in brains of mice treated with apomorphine and its oxidized derivative
Moreira, J. C. F., Dal‐Pizzol, F., Bonatto, F., et al. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.051 · Cited by 13
“Increasing evidence suggests that some of the neurotoxic effects of dopamine, apomorphine and other dopamine agonists might be mediated by their quinone and semiquinone oxidation derivatives [3,11,16,28].”
Background
Immunohistochemical evidence and ultrastructural compartmentalization of a new antioxidant enzyme in the rat substantia nigra
Fornai, F., Gesi, M., Saviozzi, M., Lenzi, P., Piaggi, S., Ferrucci, M., & Casini, A. (2001) · Journal of Neurocytology · doi:10.1023/a:1011973522055 · Cited by 13
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate
Eger, G. A., Ferreira, V. V., Batista, C. R., Bonde, H., Lima, D. D. D., Wyse, A. T. S., Cruz, J. N. D., Rodrigues, A. F., Magro, D. D. D., & Cruz, J. G. P. D. (2016) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201620140490 · Cited by 13
“Oxidation of dopamine can produce both superoxide and hydrogen peroxide, which may then form hydroxyl radicals in the presence of certain metals (Graham 1978).”
Parkinson's disease
Marsden, C. D. (1992) · Postgraduate Medical Journal · doi:10.1136/pgmj.68.801.538 · Cited by 13
Mechanism of activation of rat liver microsomal glutathione transferase by noradrenaline and xanthine oxidase
Lundqvist, G., & Morgenstern, R. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90702-k · Cited by 13

Authors: GRAHAM, D. G.
Affiliations: Duke Medical Center (US)
Corresponding author: GRAHAM, DOYLE G.
Venue: Molecular Pharmacology
Publisher: Elsevier BV
Published: 1978-07
Volume: 14
Issue: 4
Pages: 633-643
ISSN: 0026-895X (ISSN-L)
DOI: 10.1016/s0026-895x(25)13535-9
OpenAlex: W2211987820
Cited by: 1,126
References: 0
Citations by year: 2026: 11 · 2025: 12 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 23 · 2019: 26 · 2018: 29 · 2017: 30 · 2016: 26 · 2015: 29 · 2014: 26 · 2013: 26 · 2012: 49
FWCI: 1.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: catecholamines, autoxidation, periodate oxidation, 6-hydroxydopamine, dopamine, norepinephrine, epinephrine, aminochrome, adrenochrome, o-quinones, p-quinones, cyclization, tautomerism, neuromelanin
MeSH terms: Catecholamines, Dopamine, Epinephrine, Hydroxydopamines, Melanins, Norepinephrine, Oxidation-Reduction, Quinones, Monophenol Monooxygenase

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Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

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