A high-protein diet enhances satiety without conditioned taste aversion in the rat
Abstract
In order to determine the respective roles of conditioned food aversion, satiety and palatability, we studied behavioral responses to a 50% total milk protein diet, compared with those to a normal protein diet containing 14% total milk protein. Different paradigms were employed, including meal pattern analysis, two-choice testing, flavor testing, a behavioral satiety sequence (BSS) and taste reactivity. Our experiments showed that only behavioral and food intake parameters were disturbed during the first day when an animal ate the high-protein (P50) diet, and that most parameters returned to baseline values as soon as the second day of P50. Rats adapted to P50 did not acquire a conditioned taste aversion (CTA) but exhibited satiety, and a normal BSS. The initial reduction in high-protein diet intake appeared to result from the lower palatability of the food combined with the satiety effect of the high-protein diet and the delay required for metabolic adaptation to the higher protein level.
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High-protein diets tend to suppress food intake in both humans and rodents.
“High-protein diets tend to suppress food intake in both humans and rodents”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [64]
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- Authors
- Bensaı̈d, A., Tomé, D., L'Heureux-Bourdon, D., Even, P., Gietzen, D., Morens, C., Gaudichon, C., Larue-Achagiotis, C., & Fromentin, G.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- University of California, Davis (US)
- Corresponding author
- Fromentin, Gilles
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 78
- Issue
- 2
- Pages
- 311-320
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2017173142
- Cited by
- 100
- References
- 32
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- high-protein diet, satiety, conditioned taste aversion, dietary intake, palatability, milk protein, taste reactivity, metabolic adaptation, rats
- MeSH terms
- Animals, Animals, Newborn, Avoidance Learning, Behavior, Animal, Choice Behavior, Conditioning, Psychological, Dose-Response Relationship, Drug, Feeding Behavior, Food Preferences, Grooming, Male, Milk Proteins, Motor Activity, Rest, Satiety Response, Taste, Rats, Wistar, Rats
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