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Cited by 24Regulation of Appetite and ObesityAnimal Nutrition and PhysiologyBiochemical Analysis and Sensing Techniques

Protein status modulates the rewarding value of foods and meals to maintain an adequate protein intake

Open access
Tomé, Daniel, Chaumontet, Catherine, Even, Patrick C., Darcel, Nicolas, Azzout-Marniche, Dalila·2019·Physiology & Behavior
DOI 10.1016/j.physbeh.2019.03.012
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Abstract

Proteins are dietary components that contribute to nutritional needs of the body through the provision of nitrogen and amino acids. Protein status is tightly and continuously controlled to prevent or counteract protein deficiency and to maintain or restore an adequate protein status. Animals learn to detect and avoid diets deficient or devoid in protein or in at least one indispensable amino acid and when given a choice reject these diets. Diets restricted marginally in protein or in one or more amino acids more often induce hyperphagia, interpreted as an attempt to increase protein or amino acid intake and to meet the need for protein and amino acids. The increase in energy intake induced by a low protein diet is compensated for by an increased energy expenditure that restrains the gain in adiposity. The status of protein and/or amino acid insufficiency induced by protein or amino acid restricted diets is characterized by a profile of peripheral and central signals that contribute to modulate peripheral metabolic adaptations and central pathways involved in the control of feeding behaviour. These processes impact on the motivation for food and food choice, with an appetite for protein and/or for the limiting amino acid (s) associated with a reward driven sensitivity to protein and amino acid content of food and diets, which leads to restore or maintain an adequate protein status. In contrast to a protein-restricted diet, high-protein diets are usually reported to decrease food intake in both animals and humans, at least for a transient period, in relation to a reported satiating effect of proteins through activation of anorexigenic pathways.

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  • A large and growing literature clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein.

    “there is a large and growing literature that rather clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein”

    From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [59]

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  1. Chaumontet C, Azzout-Marniche D, Blais A, Piedcoq J, Tomé D, Gaudichon C, Even PC. Low protein- low methionine/high carbohydrate diets induced hyperphagia, increased energy expenditure and FGF21, decreased IGF1 and modestly affected adiposity in female BalbC mice.Am J Physiol, in press

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Authors
Tomé, D., Chaumontet, C., Even, P. C., Darcel, N., & Azzout-Marniche, D.
Affiliations
AgroParisTech (FR)
Corresponding author
Tomé, Daniel
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2019-07
Volume
206
Pages
7-12
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2019.03.012
OpenAlex
W2923369957
Cited by
24
References
78
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 1
FWCI
0.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Physiology & Behavior (acceptedVersion, other-oa)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
protein status, protein intake, food reward, food choice, protein deficiency, amino acid restriction, hyperphagia, energy expenditure, appetite, satiety, high-protein diet, feeding behaviour
MeSH terms
Animals, Energy Intake, Diet, Dietary Proteins, Eating, Feeding Behavior, Humans, Reward, Meals

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