Homeostatic regulation of protein intake: in search of a mechanism

Morrison, Christopher D.; Reed, Scott D.; Henagan, Tara M.

doi:10.1152/ajpregu.00609.2011

Cited by 99Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesBiochemical Analysis and Sensing Techniques

Homeostatic regulation of protein intake: in search of a mechanism

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Morrison, Christopher D., Reed, Scott D., Henagan, Tara M.·2012·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00609.2011PMC PMC3330767

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Abstract

Free-living organisms must procure adequate nutrition by negotiating an environment in which both the quality and quantity of food vary markedly. Recent decades have seen marked progress in our understanding of neural regulation of feeding behavior. However, this progress has occurred largely in the context of energy intake, despite the fact that food intake is influenced by more than just the energy content of the diet. A large number of behavioral studies indicate that both the quantity and quality of dietary protein can markedly influence food intake. High-protein diets tend to reduce intake, low-protein diets tend to increase intake, and rodent models seem to self-select between diets in order to meet protein requirements and avoid diets that are imbalanced in amino acids. Recent work suggests that the amino acid leucine regulates food intake by altering mTOR and AMPK signaling in the hypothalamus, while activation of GCN2 within the anterior piriform cortex contributes to the detection and avoidance of amino acid-imbalanced diets. This review focuses on the role that these and other signaling systems may play in mediating the homeostatic regulation of protein balance, and in doing so, highlights our lack of knowledge regarding the physiological and neurobiological mechanisms that might underpin such a regulatory phenomenon.

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A large and growing literature clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein.
“there is a large and growing literature that rather clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [52]

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Authors: Morrison, C. D., Reed, S. D., & Henagan, T. M.
Affiliations: Pennington Biomedical Research Center (US)
Corresponding author: Morrison, Christopher D.
ORCID: Morrison, Christopher D.
Reed, Scott D.
Henagan, Tara M.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2012-04-15
Volume: 302
Issue: 8
Pages: R917-R928
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00609.2011
PMC: PMC3330767
OpenAlex: W2138267151
Cited by: 99
References: 153
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 5 · 2012: 4
FWCI: 1.06
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK081563, P30DK072476)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: proteostasis, dietary protein quality, amino acid balance, mTOR signaling, AMPK signaling, hypothalamus, GCN2, piriform cortex, self-selected diet, feeding behavior
MeSH terms: Brain, Energy Intake, Dietary Proteins, Feeding Behavior, Homeostasis, Humans, Signal Transduction

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Homeostatic regulation of protein intake: in search of a mechanism

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