Control of protein and energy intake - brain mechanisms
Abstract
The protein content of the diet has long been investigated for its influence on food behavior. High-protein diets promote satiety and reduce calorie intake, whereas results for low-protein diets are more contradictory and less established. Protein sensing might take place in the oral cavity or in the post-oral gastrointestinal tract, where specific receptors have been found. Protein signaling to the brain may act through the vagal nerve and involve gastric hormones, such as cholecystokinin and peptide YY. Other pathways are post-absorptive signaling and the direct influence of brain levels of amino acids. High-protein diet enhances the activity of brain satiety centers, mainly the nucleus of the solitary tract and arcuate nucleus, although the activity of brain reward centers might also be modified. A better understanding of the role of both homeostatic and hedonic systems is needed to fully describe the influence of protein on food intake.
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High-protein diets tend to suppress food intake in both humans and rodents.
“High-protein diets tend to suppress food intake in both humans and rodents”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [54]
A large and growing literature clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein.
“there is a large and growing literature that rather clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [54]
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- Authors
- Davidenko, O., Darcel, N., Fromentin, G., & Tomé, D.
- Affiliations
- AgroParisTech (FR)
- Physiologie de la Nutrition et du Comportement Alimentaire (FR)
- Corresponding author
- Tomé, D
- Venue
- European Journal of Clinical Nutrition
- Published
- 2013-05
- Volume
- 67
- Issue
- 5
- Pages
- 455-461
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2062265778
- Cited by
- 63
- References
- 84
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- dietary protein, satiety, food intake regulation, protein sensing, gut-brain signaling, vagus nerve, cholecystokinin, peptide YY, amino acid signaling, nucleus tractus solitarius, arcuate nucleus, high-protein diet
- MeSH terms
- Amino Acids, Appetite Regulation, Brain, Energy Intake, Diet, Dietary Proteins, Feeding Behavior, Humans, Reward, Satiety Response, Signal Transduction, Diet, Protein-Restricted
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