Cited by 63Regulation of Appetite and ObesityNutrition, Health and Food BehaviorBiochemical Analysis and Sensing Techniques

Control of protein and energy intake - brain mechanisms

Davidenko, O, Darcel, N, Fromentin, G, Tomé, D·2013·European Journal of Clinical Nutrition

Abstract

The protein content of the diet has long been investigated for its influence on food behavior. High-protein diets promote satiety and reduce calorie intake, whereas results for low-protein diets are more contradictory and less established. Protein sensing might take place in the oral cavity or in the post-oral gastrointestinal tract, where specific receptors have been found. Protein signaling to the brain may act through the vagal nerve and involve gastric hormones, such as cholecystokinin and peptide YY. Other pathways are post-absorptive signaling and the direct influence of brain levels of amino acids. High-protein diet enhances the activity of brain satiety centers, mainly the nucleus of the solitary tract and arcuate nucleus, although the activity of brain reward centers might also be modified. A better understanding of the role of both homeostatic and hedonic systems is needed to fully describe the influence of protein on food intake.

Integrity signals

Registry

Crossref · 10.1038/ejcn.2013.73

Cites

85 of 85 references verified0 citation errors · 0 not checkable

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  • High-protein diets tend to suppress food intake in both humans and rodents.

    “High-protein diets tend to suppress food intake in both humans and rodents”
  • A large and growing literature clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein.

    “there is a large and growing literature that rather clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein”

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Authors
Davidenko, O., Darcel, N., Fromentin, G., & Tomé, D.
Affiliations
  • AgroParisTech (FR)
  • Physiologie de la Nutrition et du Comportement Alimentaire (FR)
Corresponding author
Tomé, D
Venue
European Journal of Clinical Nutrition
Published
2013-05
Volume
67
Issue
5
Pages
455-461
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
OpenAlex
W2062265778
Cited by
63
References
84
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 2
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
dietary protein, satiety, food intake regulation, protein sensing, gut-brain signaling, vagus nerve, cholecystokinin, peptide YY, amino acid signaling, nucleus tractus solitarius, arcuate nucleus, high-protein diet
MeSH terms
Amino Acids, Appetite Regulation, Brain, Energy Intake, Diet, Dietary Proteins, Feeding Behavior, Humans, Reward, Satiety Response, Signal Transduction, Diet, Protein-Restricted

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