Cited by 76Neuroscience and Neuropharmacology ResearchTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia.

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Krystal, John H., Tolin, David F., Sanacora, Gerard, Castner, Stacy A., Williams, Graham V., Aikins, Deane E., Hoffman, Ralph E., D'Souza, D. Cyril·2009·Drug Discovery Today

Abstract

Current treatments for psychiatric disorders were developed with the aim of providing symptomatic relief rather than reversing underlying abnormalities in neuroplasticity or neurodevelopment that might contribute to psychiatric disorders. This review considers the possibility that psychiatric treatments might be developed that target neuroplasticity deficits or that manipulate neuroplasticity in novel ways. These treatments might not provide direct symptomatic relief. However, they might complement or enhance current pharmacotherapies and psychotherapies aimed at the prevention and treatment of psychiatric disorders. In considering neuroplasticity as a target for the treatment of psychiatric disorders, we build on exciting new findings in the areas of anxiety disorders, mood disorders, and schizophrenia.

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Crossref · 10.1016/j.drudis.2009.05.002

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  1. [53]Norberg MM 2008 A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy Biol Psychiatry 18313643

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Authors
Krystal, J. H., Tolin, D. F., Sanacora, G., Castner, S. A., Williams, G. V., Aikins, D. E., Hoffman, R. E., & D'Souza, D. C.
Affiliations
  • Yale University (US)
  • Hartford Hospital (US)
  • Yale New Haven Hospital (US)
Corresponding author
Krystal, John H.
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2009-07
Volume
14
Issue
13-14
Pages
690-697
ISSN
1359-6446 (ISSN-L)
OpenAlex
W2047894110
Cited by
76
References
131
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 4
FWCI
0.52
Type
journal article
Language
en
Open access
Locations
  • Drug Discovery Today (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5k05aa014906-03)
  • National Institute on Alcohol Abuse and Alcoholism (K05 AA 14906-01, R01 AA11321, R01AA011321, K05-AA014906, I-P50 AA-12870, P50AA012870)
  • National Institute of Mental Health (P50MH068789, K02MH076222, MH P50 MH44866, P50MH044866)
  • National Institute on Drug Abuse (R21DA024228)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
neuroplasticity, pharmacotherapy, anxiety disorders, mood disorders, schizophrenia, brain development, symptom relief
MeSH terms
Animals, Anxiety Disorders, Pharmaceutical Preparations, Humans, Neuronal Plasticity, Schizophrenia, Multicenter Studies as Topic, Drug Delivery Systems, Mood Disorders

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