Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia.
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Current treatments for psychiatric disorders were developed with the aim of providing symptomatic relief rather than reversing underlying abnormalities in neuroplasticity or neurodevelopment that might contribute to psychiatric disorders. This review considers the possibility that psychiatric treatments might be developed that target neuroplasticity deficits or that manipulate neuroplasticity in novel ways. These treatments might not provide direct symptomatic relief. However, they might complement or enhance current pharmacotherapies and psychotherapies aimed at the prevention and treatment of psychiatric disorders. In considering neuroplasticity as a target for the treatment of psychiatric disorders, we build on exciting new findings in the areas of anxiety disorders, mood disorders, and schizophrenia.
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Brain disorders can be considered maladies of neuroplasticity.
“To some extent, brain disorders can be considered maladies of neuroplasticity (Krystal et al., 2009).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Krystal et al., 2009
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- [53]Norberg MM 2008 A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy Biol Psychiatry 18313643
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“Key mechanisms at both the cellular and molecular level will be discussed below in terms of their contribution to AE-induced enhancements in hippocampal functioning.”
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- Authors
- Krystal, J. H., Tolin, D. F., Sanacora, G., Castner, S. A., Williams, G. V., Aikins, D. E., Hoffman, R. E., & D'Souza, D. C.
- Affiliations
- Yale University (US)
- Hartford Hospital (US)
- Yale New Haven Hospital (US)
- Corresponding author
- Krystal, John H.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 14
- Issue
- 13-14
- Pages
- 690-697
- ISSN
- 1359-6446 (ISSN-L)
- PMC
- PMC2898127
- OpenAlex
- W2047894110
- Cited by
- 76
- References
- 131
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 4
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k05aa014906-03)
- National Institute on Alcohol Abuse and Alcoholism (K05 AA 14906-01, R01 AA11321, R01AA011321, K05-AA014906, I-P50 AA-12870, P50AA012870)
- National Institute of Mental Health (P50MH068789, K02MH076222, MH P50 MH44866, P50MH044866)
- National Institute on Drug Abuse (R21DA024228)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- neuroplasticity, pharmacotherapy, anxiety disorders, mood disorders, schizophrenia, brain development, symptom relief
- MeSH terms
- Animals, Anxiety Disorders, Pharmaceutical Preparations, Humans, Neuronal Plasticity, Schizophrenia, Multicenter Studies as Topic, Drug Delivery Systems, Mood Disorders
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