The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Oxytocin and appetite
Abstract
Oxytocin has potent central effects on feeding behaviour, as well as on social and sexual behaviours, and one likely substrate for its anorectic effect is the ventromedial nucleus of the hypothalamus. This nucleus expresses a high density of oxytocin receptors, but contains very few oxytocin-containing fibres, hence it is a likely target of 'neurohormonal' actions of oxytocin, including possibly oxytocin released from the dendrites of magnocellular oxytocin neurones. As oxytocin release from dendrites is regulated independent of electrical activity and of secretion from the neurohypophysis, exactly how this release is regulated by metabolic and reproduction-related signals remains to be established fully. Intriguingly though, it looks as though this central release of oxytocin from magnocellular neurons might be instrumental in a fundamental shift in motivational behaviour - switching behaviour from being driven by the need to find and consume food, to the need to reproduce.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Oxytocin regulates feeding and metabolism at multiple sites (34,35).Its receptors are expressed throughout the gastrointestinal tract, and on gastric vagal nerve endings (36).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [35]
Citations
Cites
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494
Cited by
Sorted by citations
Items 101–112 of 112
SNAP-47 mediates somatic oxytocin dynamics in hypothalamic neurons
Aznar-Escolano, B., Royo, M. V. V., Madrigal, M. P., Portalés, A., Villanueva, J., Gutiérrez, L. M., & Jurado, S. (2026) · Communications Biology · doi:10.1038/s42003-025-09442-5 · Cited by 1
Hypothalamic Dysfunction (Hypothalamic Syndromes)
Gan, H., Cerbone, M., & Dattani, M. (2022) · doi:10.1093/med/9780198870197.003.0032 · Cited by 1
Oxytocin Effects on Chemosensory Function in a Clinical Setting—a Preliminary Study
Burke, S., Graf, R., Ochsenbein‐Kölble, N., & Hummel, T. R. (2015) · Chemosensory Perception · doi:10.1007/s12078-015-9185-8 · Cited by 1
“Moreover, studies in mice in which the oxytocin gene had been deleted showed that also the gustatory sensory functions may be modulated by oxytocin functioning (Leng et al. 2008).”
BackgroundNowicki, J. P., Pratchett, M. S., Walker, S. P. W., Coker, D. J., & O’Connell, L. A. (2017) · King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) · doi:10.1101/214759 · Cited by 1
Actions of appetite regulating peptides on supraoptic nucleus (SON) oxytocin neurones
Velmurugan, S. (2009) · ERA · Cited by 1
Modulation of Peripheral Taste Function by Glial-like Taste Cells
Sinclair, M. S. (2012)
Caquineau, C., & Leng, G. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_20
The Neuroendocrine and Cardiovascular Responses to a Pup in Male Prairie Voles (M. ochrogaster)
Kenkel, W. M. (2013) · Figshare
顾, 文., 郝, 振., 毛, 俊., & 田, 莹. (2025) · Research Square · doi:10.21203/rs.3.rs-6817321/v1
Gu, W., Mao, J., Wang, X., Lü, F., He, P., Cai, L., Dai, L., Jia, M., Tian, Y., & Hao, Z. (2026) · Journal of Oceanology and Limnology · doi:10.1007/s00343-026-5280-8
Circuits neuronaux sous-tendant la régulation émotionnelle par le système ocytocinergique
Goyon, S. (2018) · theses.fr (ABES) · doi:10.70675/c8c9bec0z7b79z4826z862az93b128e1ada6
Prescribed Interventions to Reduce Depression
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_22
Metadata
- Authors
- LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y.
- Affiliations
- Jichi Medical University (JP)
- Corresponding author
- LENG, G
- Venue
- Progress in brain research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 137-151
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1884119423
- Cited by
- 112
- References
- 114
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 9 · 2012: 11
- FWCI
- 13.33
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Society of Edinburgh
- Biotechnology and Biological Sciences Research Council (BB/E015123/1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, appetite, feeding behaviour, anorectic effect, ventromedial hypothalamus, oxytocin receptor, magnocellular neurons, neurohumoral regulation, reproduction
- MeSH terms
- Animals, Appetite, Dendrites, Biological Evolution, Feeding Behavior, Female, Fishes, Humans, Hunger, Lactation, Mammals, Marsupialia, Milk, Neurons, Oxytocin, Pituitary Gland, Posterior, Sexual Behavior, Sexual Behavior, Animal, Social Behavior, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
