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Cellular Senescence
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“Cell proliferation in settings of insufficient telomerase results in progressive telomere shortening, ultimately leading to replicative senescence as chromosome end-protection is compromised at a subset of short telomeres (Rodier et al., 2005; Sherr and DePinho, 2000).”
From Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice (2010) · cites this paper as Sherr and DePinho, 2000
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The serial cultivation of human diploid cell strains
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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
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“…same panoply of cell cycle regulatory proteins nortemptation has been to link conclusions drawn from mally associated with arresting cells and undergo “prestudies in these different cell systems, equating senes- mature senescence” (Serrano et al., 1997), whereas escence in mouse and human cells.”
BackgroundExtension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
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Self-citationTumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566
Self-citationMyc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
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Self-citationKiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206 · cited 1×
“Removing the telomerements TERT reconstitution in the immortalization pro- cess (Kiyono et al., 1998).”
Backgroundp53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086
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Metadata
- Authors
- Sherr, C. J., & DePinho, R. A.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Harvard University (US)
- Corresponding author
- Sherr, Charles J
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 102
- Issue
- 4
- Pages
- 407-410
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2324248025
- Cited by
- 745
- References
- 20
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 13 · 2023: 10 · 2022: 13 · 2021: 19 · 2020: 20 · 2019: 16 · 2018: 7 · 2017: 30 · 2016: 17 · 2015: 19 · 2014: 24 · 2013: 19 · 2012: 31
- FWCI
- 36.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- cellular senescence, biological aging, human fibroblasts, mouse fibroblasts, culture shock, telomere integrity, cell cycle inhibitors, oncogenic transformation, chromosome stability
- MeSH terms
- Animals, Humans, Mitosis, Models, Biological, Telomere, Cellular Senescence
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