Cellular Senescence

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

Todaro, G. J., & Green, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.299 · Cited by 2,747

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development · doi:10.1101/gad.12.15.2424 · Cited by 1,245

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206 · cited 1×

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086

Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts

Wei, W., Hemmer, R. M., & Sedivy, J. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.6748-6757.2001 · Cited by 217

TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression

Kaminker, P. G., Kim, S., Taylor, R. D., Zebarjadian, Y., Funk, W. D., Morin, G. B., Yaswen, P., & Campisi, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105968200 · Cited by 223

Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated Protein Kinase/Sp1–Mediated Activation of Two GC-Rich Promoter Elements

Dasari, A., Bartholomew, J. N., Volonté, D., & Galbiati, F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1236 · Cited by 215

Expression of Caveolin-1 Induces Premature Cellular Senescence in Primary Cultures of Murine Fibroblasts

Volonté, D., Zhang, K., Lisanti, M. P., & Galbiati, F. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-11-0529 · Cited by 215

Wide spectrum of tumors in knock‐in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

Sotillo, R., Dubus, P., Martn, J., de la Cueva, E., Ortega, S., Malumbres, M., & Barbacid, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6637 · Cited by 208

Tumour suppression by p53: the importance of apoptosis and cellular senescence

Zuckerman, V., Wolyniec, K., Sionov, R. V., Haupt, S., & Haupt, Y. (2009) · The Journal of Pathology · doi:10.1002/path.2584 · Cited by 222

NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates

Yang, D., Sun, B., Li, S., Wei, W., Liu, X., Cui, X., Zhang, X., Liu, N., Yan, L., Deng, Y., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add1951 · Cited by 217

Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci

Zhang, H., Pan, K.-H., & Cohen, S. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2627983100 · Cited by 209

Polycomb repression: from cellular memory to cellular proliferation and cancer

Jacobs, J. J. L., & van Lohuizen, M. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00052-5 · Cited by 212

Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening

Melk, A., Kittikowit, W., Sandhu, I., Halloran, K. M., Grimm, P., Schmidt, B. M. W., & Halloran, P. F. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00032.x · Cited by 205

Distinguishing melanocytic nevi from melanoma by DNA copy number changes: comparative genomic hybridization as a research and diagnostic tool

Bauer, J. M., & Bastian, B. C. (2006) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2005.00055.x · Cited by 207

Vascular smooth muscle cell senescence in atherosclerosis

GORENNE, I., KAVURMA, M., SCOTT, S., & BENNETT, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.004 · Cited by 196

Regulation of AIF expression by p53

Stambolsky, P., Weisz, L., Shats, I., Klein, Y., Goldfinger, N., Oren, M., & Rotter, V (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401965 · Cited by 194

20 years studying p53 functions in genetically engineered mice

Donehower, L. A., & Lozano, G. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2731 · Cited by 196

Transient Inactivation of Rb and ARF Yields Regenerative Cells from Postmitotic Mammalian Muscle

Pajcini, K. V., Corbel, S. Y., Sage, J., Pomerantz, J. H., & Blau, H. M. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.05.022 · Cited by 193

Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASGPreprint

Sun, L.-Q., Lee, D. W., Zhang, Q., Xiao, W., Raabe, E. H., Meeker, A. K., Miao, D., Huso, D. L., & Arceci, R. J. (2004) · Genes & Development · doi:10.1101/gad.1176104 · Cited by 186

Lack of Replicative Senescence in Normal Rodent Glia

Mathon, N. F., Malcolm, D. S., Harrisingh, M. C., Cheng, L., & Lloyd, A. C. (2001) · Science · doi:10.1126/science.1056782 · Cited by 183

Temporal dissection of p53 function in vitro and in vivo

Christophorou, M. A., Martı́n-Zanca, D., Soucek, L., Lawlor, E. R., Swigart, L. B., Verschuren, E. W., & Evan, G. I. (2005) · Nature Genetics · doi:10.1038/ng1572 · Cited by 184

The Transcription Factor FOXM1 (Forkhead box M1)

Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 180

Mesenchymal Stem Cells: Molecular Targets for Tissue Engineering

Satija, N. K., Gurudutta, G. U., Sharma, S., Afrin, F., Gupta, P., Verma, Y. K., Singh, V. K., & Tripathi, R. (2007) · Stem Cells and Development · doi:10.1089/scd.2006.9998 · Cited by 175

Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells

Yokoi, T., Fukuo, K., Yasuda, O., Hotta, M., Miyazaki, J., Takemura, Y., Kawamoto, H., Ichijo, H., & Ogihara, T. (2006) · Diabetes · doi:10.2337/db05-1607 · Cited by 169

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kineticsPreprint

Aslanian, A., Iaquinta, P. J., Verona, R. I., & Lees, J. A. (2004) · Genes & Development · doi:10.1101/gad.1196704 · Cited by 176

Germ Line Transmission of the Cdk4R24C Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence

Rane, S. G., Cosenza, S. C., Mettus, R. V., & Reddy, E. P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.644-656.2002 · Cited by 167

In Vivo-Restricted and Reversible Malignancy Induced by Human Herpesvirus-8 KSHV: A Cell and Animal Model of Virally Induced Kaposi's Sarcoma

Mutlu, A. D., Cavallin, L. E., Vincent, L., Chiozzini, C., Eroles, P., Duran, E. M., Asgari, Z., Hooper, A. T., Perle, K. M. D. L., Hilscher, C., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.015 · Cited by 163

The disparity between human cell senescence in vitro and lifelong replication in vivo

Rubin, H. (2002) · Nature Biotechnology · doi:10.1038/nbt0702-675 · Cited by 171

Glycated Collagen I Induces Premature Senescence-Like Phenotypic Changes in Endothelial Cells

Chen, J., Brodsky, S. V., Goligorsky, D. M., Hampel, D. J., Li, H., Gross, S. S., & Goligorsky, M. S. (2002) · Circulation Research · doi:10.1161/01.res.0000022161.42655.98 · Cited by 164

HIF1α delays premature senescence through the activation of MIFPreprint

Welford, S. M., Bedogni, B., Gradin, K., Poellinger, L., Powell, M. B., & Giaccia, A. J. (2006) · Genes & Development · doi:10.1101/gad.1471106 · Cited by 163

Cell senescence and hypermitogenic arrest

Blagosklonny, M. V. (2003) · The EMBO Reports · doi:10.1038/sj.embor.embor806 · Cited by 156

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

Leontieva, O. V., & Blagosklonny, M. V. (2010) · Aging · doi:10.18632/aging.100265 · Cited by 163

Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease

Sis, B., Tasanarong, A., Khoshjou, F., Dadras, F., Solez, K., & Halloran, P. F. (2007) · Kidney International · doi:10.1038/sj.ki.5002039 · Cited by 159

Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression

Bahta, A. W., Farjo, N. P., Farjo, B., & Philpott, M. P. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701147 · Cited by 158

Increased Expression of Senescence-Associated Cell Cycle Inhibitor p16 in Deteriorating Renal Transplants and Diseased Native Kidney

Melk, A., Schmidt, B. M. W., Vongwiwatana, A., Rayner, D. C., & Halloran, P. F. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00846.x · Cited by 154

Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells

Allsopp, R. C., Morin, G. B., Horner, J. W., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Nature Medicine · doi:10.1038/nm0403-369 · Cited by 155

Vascular aging: Chronic oxidative stress and impairment of redox signaling—consequences for vascular homeostasis and disease

Bachschmid, M. M., Schildknecht, S., Matsui, R., Zee, R. S., Haeussler, D. J., Cohen, R. A., Pimental, D. R., & van der Loo, B. (2012) · Annals of Medicine · doi:10.3109/07853890.2011.645498 · Cited by 159

TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 and Inhibits Senescence

Brummelkamp, T. R., Kortlever, R. M., Lingbeek, M., Trettel, F., MacDonald, M. E., van Lohuizen, M., & Bernards, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110492200 · Cited by 154

CBX7 is a tumor suppressor in mice and humans

Forzati, F., Federico, A., Pallante, P., Abbate, A., Esposito, F., Malapelle, U., Sepe, R., Palma, G., Troncone, G., Scarfò, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58620 · Cited by 149

Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells

Ferrón, S., Mira, H., Franco, S., Cano-Jaimez, M., Bellmunt, E., Ramírez, C., Fariñas, I., & Blasco, M. A. (2004) · Development · doi:10.1242/dev.01215 · Cited by 152

C/EBPβ cooperates with RB:E2F to implement RasV12‐induced cellular senescence

Sebastian, T. B., Malı́k, R., Thomas, S., Sage, J., & Johnson, P. F. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600789 · Cited by 151

Crime and punishment

Sharpless, N. E., & DePinho, R. A. (2005) · Nature · doi:10.1038/436636a · Cited by 149

Loss of Proliferative Capacity and Induction of Senescence in Oxidatively Stressed Human Fibroblasts

Chen, J., Stoeber, K., Kingsbury, S. R., Ozanne, S. E., Williams, G. H., & Hales, C. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409153200 · Cited by 148

Stem cells, senescence, neosis and self-renewal in cancer.

Rajaraman, R., Guernsey, D. L., Rajaraman, M. M., & Rajaraman, S. R. (2006) · Cancer Cell International · doi:10.1186/1475-2867-6-25 · Cited by 152

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

Ha, L., Ichikawa, T., Anver, M. R., Dickins, R. A., Lowe, S. W., Sharpless, N. E., Krimpenfort, P., DePinho, R. A., Bennett, D. C., Sviderskaya, E. V., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611638104 · Cited by 147

Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization.

Kondoh, H., LLeonart, M. E., Bernard, D., & Gil, J. (2007) · PubMed · doi:10.14670/hh-22.85 · Cited by 143

Telomeres, sex, reactive oxygen species, and human cardiovascular aging

Aviv, A. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0377-8 · Cited by 138

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescencePreprint

Zou, X., Ray, D., Aziyu, A., Christov, K. T., Boiko, A. D., Gudkov, A. V., & Kiyokawa, H. (2002) · Genes & Development · doi:10.1101/gad.1033002 · Cited by 146

Suppression of Ras-stimulated transformation by the JNK signal transduction pathwayPreprint

Kennedy, N. J., Sluss, H. K., Jones, S. N., Bar‐Sagi, D., Flavell, R. A., & Davis, R. J. (2003) · Genes & Development · doi:10.1101/gad.1062903 · Cited by 139

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19 ARF –p53 signalingPreprint

Shvarts, A., Brummelkamp, T. R., Scheeren, F., Koh, E., Daley, G. Q., Spits, H., & Bernards, R. (2002) · Genes & Development · doi:10.1101/gad.929302 · Cited by 145

Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence

Agherbi, H., Gaussmann-Wenger, A., Verthuy, C., Chasson, L., Serrano, M., & Djabali, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005622 · Cited by 142

Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer

Tian, S., Roepman, P., Veer, L. J. V., Bernards, R., Snoo, F. D., & Glas, A. M. (2010) · Biomarker Insights · doi:10.4137/bmi.s6184 · Cited by 137

Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration

Liao, Z., Li, S., Lu, S., Liu, H., Li, G., Ma, L., Luo, R., Ke, W., Wang, B., Xiang, Q., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120850 · Cited by 135

Reduced hematopoietic reserves in DNA interstrand crosslink repair‐deficient Ercc1−/− mice

Prasher, J. M., Lalai, A. S., Heijmans‐Antonissen, C., Ploemacher, R., Hoeijmakers, J. H. J., Touw, I. P., & Niedernhofer, L. J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600542 · Cited by 141

Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch

Fujimaki, K., Li, R., Chen, H., Croce, K. D., Zhang, H. H., Xing, J., Bai, F., & Yao, G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915905116 · Cited by 136

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells

Lee, K. E., & Bar‐Sagi, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.020 · Cited by 138

Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer

Bastian, B. C. (2003) · Oncogene · doi:10.1038/sj.onc.1206463 · Cited by 130

Mdm2 haplo‐insufficiency profoundly inhibits Myc‐induced lymphomagenesis

Alt, J. R., Greiner, T. C., Cleveland, J. L., & Eischen, C. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg133 · Cited by 129

Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord

Roy, N. S., Nakano, T., Keyoung, H. M., Windrem, M. S., Rashbaum, W. K., Alonso, M. L., Kang, J., Peng, W., Carpenter, M. K., Lin, J. H.-C., et al. (2004) · Nature Biotechnology · doi:10.1038/nbt944 · Cited by 129

Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging

Zhang, H. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20919 · Cited by 136

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-X L

Maclean, K. H., Keller, U. B., Galindo, C. R., Nilsson, J. A., & Cleveland, J. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7256-7270.2003 · Cited by 128

Senescence-Associated Secretory Phenotype and Its Possible Role in Chronic Obstructive Pulmonary Disease

Kumar, M., Seeger, W., & Voswinckel, R. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0382ps · Cited by 131

Immortalisation and transformation revisited

Drayton, S. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00271-4 · Cited by 129

5′-3′-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage

Chen, J., & Kastan, M. B. (2010) · Genes & Development · doi:10.1101/gad.1968910 · Cited by 127

Does p53 affect organismal aging?

Donehower, L. A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10104 · Cited by 155

p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation

Schüler, M., Maurer, U., Goldstein, J. C., Breitenbücher, F., Hoffarth, S., Waterhouse, N. J., & Green, D. R. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401180 · Cited by 127

The load of short telomeres, estimated by a new method, Universal STELA, correlates with number of senescent cells

Bendix, L., Horn, P. B., Jensen, U. B., Rubelj, I., & Kølvraa, S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00568.x · Cited by 128

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformationPreprint

Woo, R. A., & Poon, R. Y. C. (2004) · Genes & Development · doi:10.1101/gad.1165204 · Cited by 129

Control of Spermatogenesis in Mice by the Cyclin D-Dependent Kinase Inhibitors p18 Ink4c and p19 Ink4d

Zindy, F., den Besten, W., Chen, B., Rehg, J. E., Latres, E., Barbacid, M., Pollard, J. W., Sherr, C. J., Cohen, P. E., & Roussel, M. F. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.3244-3255.2001 · Cited by 120

Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan

Seluanov, A., Hine, C., Bozzella, M. J., Hall, A. W., Sasahara, T. H. D. C., Ribeiro, A. A. C. M., Catania, K. C., Presgraves, D. C., & Gorbunova, V. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00431.x · Cited by 122

Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor

Sreeramaneni, R., Chaudhry, A., McMahon, M., Sherr, C. J., & Inoue, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.220-232.2005 · Cited by 123

E2F transcriptional repressor complexes are critical downstream targets of p19ARF/p53-induced proliferative arrest

Rowland, B. D., Denissov, S. G., Douma, S., Stunnenberg, H. G., Bernards, R., & Peeper, D. S. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00085-5 · Cited by 120

Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence.

Krones-Herzig, A., Adamson, E., & Mercola, D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2628034100 · Cited by 118

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

Volonte, D., Liu, Z., Musille, P. M., Stoppani, E., Wakabayashi, N., Di, Y.-P., Lisanti, M. P., Kensler, T. W., & Galbiati, F. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-09-0666 · Cited by 119

Roles and mechanisms of cellular senescence in regulation of tissue homeostasis

Ohtani, N., & Hara, E. (2013) · Cancer Science · doi:10.1111/cas.12118 · Cited by 122

Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells

Mikuła‐Pietrasik, J., Niklas, A. A., Uruski, P., Tykarski, A., & Książek, K. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03261-8 · Cited by 131

p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation

Minella, A. C., Swanger, J., Bryant, E. M., Welcker, M., Hwang, H. C., & Clurman, B. E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01225-3 · Cited by 119

Oncogene-induced Cellular Senescence

Chandeck, C., & Mooi, W. J. (2010) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e3181c66f4e · Cited by 127

New tools for functional mammalian cancer genetics

Brummelkamp, T. R., & Bernards, R. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1191 · Cited by 114

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

Tan, F. C. C., Hutchison, E. R., Eitan, E., & Mattson, M. P. (2014) · Biogerontology · doi:10.1007/s10522-014-9532-1 · Cited by 116

Cellular senescence: Its role in tumor suppression and aging

Ohtani, N., Mann, D. J., & Hara, E. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01123.x · Cited by 119

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow‐Derived Mouse Mesenchymal Stem Cells via a p53‐Dependent Mechanism: Implications for Long‐Term Culture Expansion

Boregowda, S. V., Krishnappa, V., Chambers, J. W., Lograsso, P. V., Lai, W., Ortiz, L. A., & Phinney, D. G. (2012) · STEM CELLS · doi:10.1002/stem.1069 · Cited by 114

The Pathogenesis of Tendon Microdamage in Athletes: the Horse as a Natural Model for Basic Cellular Research

Patterson‐Kane, J. C., Becker, D. L., & Rich, T. (2012) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2012.05.010 · Cited by 113

Myocardial aging

Anversa, P., Rota, M., Urbanek, K., Hosoda, T., Sonnenblick, E. H., Leri, A., Kajstura, J., & Bolli, R. (2005) · Basic Research in Cardiology · doi:10.1007/s00395-005-0554-3 · Cited by 114

Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer

Shim, J. S., Matsui, Y., Bhat, S., Nacev, B. A., Xu, J., Bhang, H.-E. C., Dhara, S., Han, K. C., Chong, C. R., Pomper, M. G., et al. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq457 · Cited by 112

Donor Cells for Nuclear Cloning: Many Are Called, but Few Are Chosen

Oback, B. J., & Wells, D. N. (2002) · Cloning and Stem Cells · doi:10.1089/153623002320253328 · Cited by 110

How does Epstein–Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma?

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