Cited by 751Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

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Cellular Senescence

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Sherr, Charles J, DePinho, Ronald A·2000·Cell

DOI 10.1016/s0092-8674(00)00046-5

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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
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Self-citation
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Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566
Self-citation
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
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Self-citation
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206 · cited 1×
“Removing the telomerements TERT reconstitution in the immortalization pro- cess (Kiyono et al., 1998).”
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p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086

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Kroustallaki, P., & Gagos, S. (2015) · Springer eBooks · doi:10.1007/978-1-4939-3070-8_10
Analysis of the function and regulation of the centrosomal protein NEDD1 during cell division and development
Manning, J. A. (2009) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
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Irelan, J. T., Wu, M.-J., Morgan, J. T., Ning, K., Xi, B., Wang, X., Xu, X., & Abassi, Y. A. (2013)
Cellular Senescence
Campisi, J. (2008) · Elsevier eBooks · doi:10.1016/b978-141603703-3.10016-0 · Cited by 1
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Ramsey, M. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/sfvt-t742

Authors: Sherr, C. J., & DePinho, R. A.
Affiliations: St. Jude Children's Research Hospital (US)
Harvard University (US)
Corresponding author: Sherr, Charles J
ORCID: Sherr, Charles J
DePinho, Ronald A
Venue: Cell
Publisher: Elsevier BV
Published: 2000-08
Volume: 102
Issue: 4
Pages: 407-410
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)00046-5
OpenAlex: W2324248025
Cited by: 745
References: 20
Citations by year: 2026: 6 · 2025: 5 · 2024: 13 · 2023: 10 · 2022: 13 · 2021: 19 · 2020: 20 · 2019: 16 · 2018: 7 · 2017: 30 · 2016: 17 · 2015: 19 · 2014: 24 · 2013: 19 · 2012: 31
FWCI: 36.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4764 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: cellular senescence, biological aging, human fibroblasts, mouse fibroblasts, culture shock, telomere integrity, cell cycle inhibitors, oncogenic transformation, chromosome stability
MeSH terms: Animals, Humans, Mitosis, Models, Biological, Telomere, Cellular Senescence

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