Cellular Senescence

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

Todaro, G. J., & Green, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.299 · Cited by 2,747

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development · doi:10.1101/gad.12.15.2424 · Cited by 1,245

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206 · cited 1×

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

The essence of senescence: Figure 1.

Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038

The RB and p53 pathways in cancer

Sherr, C. J., & McCormick, F. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00102-2 · Cited by 1,690

Genetics and biology of pancreatic ductal adenocarcinomaPreprint

Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N. M., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,611

Ink4a/Arf expression is a biomarker of aging

Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Beauséjour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., & Campisi, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg417 · Cited by 1,457

DNA Damage Foci at Dysfunctional Telomeres

Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409

Nanomaterials for Theranostics: Recent Advances and Future Challenges

Lim, E., Kim, T., Paik, S., Haam, S., Huh, Y., & Lee, K. (2014) · Chemical Reviews · doi:10.1021/cr300213b · Cited by 1,248

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.

Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196

Pancreatic cancer biology and genetics

Bardeesy, N. M., & DePinho, R. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc949 · Cited by 1,176

Forging a signature of in vivo senescence

Sharpless, N. E., & Sherr, C. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3960 · Cited by 1,104

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., & Campisi, J. (2003) · Nature Cell Biology · doi:10.1038/ncb1024 · Cited by 1,116

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,105

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00734-1 · Cited by 1,050

cGAS is essential for cellular senescence

Yang, H., Wang, H., Ren, J., Chen, Q., & Chen, Z. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705499114 · Cited by 1,009

The INK4a/ARF network in tumour suppression

Sherr, C. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096061 · Cited by 1,001

The age of cancer

DePinho, R. A. (2000) · Nature · doi:10.1038/35041694 · Cited by 951

Modelling the molecular circuitry of cancer

Hahn, W. C., & Weinberg, R. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc795 · Cited by 953

Protection of mammalian telomeres

de Lange, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205080 · Cited by 942

Senescence and immortalization: role of telomeres and telomerase

Shay, J. W., & Wright, W. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh296 · Cited by 747

Tumor suppression by Ink4a-Arf: progress and puzzles.

Lowe, S. W., & Sherr, C. J. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00013-8 · Cited by 699

Glycolytic Enzymes Can Modulate Cellular Life Span

Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A., & Beach, D. (2005) · Cancer Research · doi:10.1158/0008-5472.177.65.1 · Cited by 647

Vascular Smooth Muscle Cells Undergo Telomere-Based Senescence in Human Atherosclerosis: Effects of Telomerase and Oxidative Stress

Matthews, C., Gorenne, I., Scott, S., Figg, N., Kirkpatrick, P., Ritchie, A., Goddard, M., & Bennett, M. (2006) · Circulation Research · doi:10.1161/01.res.0000233315.38086.bc · Cited by 615

Modeling the Therapeutic Efficacy of p53 Restoration in Tumors

Martins, C. P., Brown-Swigart, L., & Evan, G. I. (2006) · Cell · doi:10.1016/j.cell.2006.12.007 · Cited by 600

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571

Comparative biology of mouse versus human cells: modelling human cancer in mice

Rangarajan, A., & Weinberg, R. A. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1235 · Cited by 579

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553

'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally

García‐Cao, I., García‐Cao, M., Martín‐Caballero, J., Criado, L. M., Klatt, P., Flores, J. M., Weill, J., Blasco, M. A., & Serrano, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf595 · Cited by 529

Oxidative stress in cell culture: an under‐appreciated problem?

Halliwell, B. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00235-7 · Cited by 534

Invited Review: Theories of aging

Weinert, B. T., & Timiras, P. S. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00288.2003 · Cited by 546

Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz, J. H., Artandi, S. E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.039 · Cited by 512

Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia

Goda, N., Ryan, H. E., Khadivi, B., McNulty, W., Rickert, R. C., & Johnson, R. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.359-369.2003 · Cited by 523

Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

Coppé, J.-P., Rodier, F., Patil, C. K., Freund, A., Desprez, P.-Y., & Campisi, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257071 · Cited by 506

Hallmarks of senescence in carcinogenesis and cancer therapy

Shay, J. W., & Roninson, I. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207518 · Cited by 502

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination

Gomes, N. M. V., Ryder, O. A., Houck, M. L., Charter, S. J., Walker, W., Forsyth, N. R., Austad, S. N., Venditti, C., Pagel, M., Shay, J. W., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00718.x · Cited by 464

Myc pathways provoking cell suicide and cancer

Nilsson, J. A., & Cleveland, J. L. (2003) · Oncogene · doi:10.1038/sj.onc.1207261 · Cited by 470

A synopsis on aging—Theories, mechanisms and future prospects

da Costa, J. P., Vitorino, R. M. P., Silva, G. M., Vogel, C., Duarte, A. C., & Rocha‐Santos, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.005 · Cited by 505

Cardiac Stem Cells and Mechanisms of Myocardial Regeneration

Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 451

INK4a/ARF: A multifunctional tumor suppressor locus

Sharpless, N. E. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.08.021 · Cited by 442

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

Ramirez, R. D., Morales, C. P., Herbert, B.-S., Rohde, J. M., Passons, C., Shay, J. W., & Wright, W. E. (2001) · Genes & Development · doi:10.1101/gad.859201 · Cited by 444

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

Itahana, K., Zou, Y., Itahana, Y., Martinez, J.-L., Beausejour, C., Jacobs, J. J. L., van Lohuizen, M., Band, V., Campisi, J., & Dimri, G. P. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.389-401.2003 · Cited by 438

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

Bardeesy, N. M., Sinha, M., Hezel, A. F., Signoretti, S., Hathaway, N. A., Sharpless, N. E., Loda, M. F., Carrasco, D. R., & DePinho, R. A. (2002) · Nature · doi:10.1038/nature01045 · Cited by 435

Impact of aging on DNA methylation

Richardson, B. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00010-2 · Cited by 429

When cells get stressed: an integrative view of cellular senescence

Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404

Cellular senescence, cancer and aging: the telomere connection

Campisi, J., Kim, S.-H., Lim, C.-S., & Rubio, M. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00160-7 · Cited by 400

HMG-CoA Reductase Inhibitors Reduce Senescence and Increase Proliferation of Endothelial Progenitor Cells via Regulation of Cell Cycle Regulatory Genes

Aßmus, B., Urbich, C., Aicher, A., Hofmann, W. K., Haendeler, J., Rössig, L., Spyridopoulos, I., Zeiher, A. M., & Dimmeler, S. (2003) · Circulation Research · doi:10.1161/01.res.0000070067.64040.7c · Cited by 392

Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway

Iwasa, H., Han, J., & Ishikawa, F. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00620.x · Cited by 407

Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

Haendeler, J., Hoffmann, J., Diehl, J. F., Vasa‐Nicotera, M., Spyridopoulos, I., Zeiher, A. M., & Dimmeler, S. (2004) · Circulation Research · doi:10.1161/01.res.0000121104.05977.f3 · Cited by 382

Oncogene-Induced Cell Senescence — Halting on the Road to Cancer

Mooi, W. J., & Peeper, D. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062285 · Cited by 371

Regulation of cellular senescence by p53

Itahana, K., Dimri, G., & Campisi, J. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02228.x · Cited by 365

Cellular senescence in osteoarthritis pathology

McCulloch, K., Litherland, G. J., & Rai, T. S. (2017) · Aging Cell · doi:10.1111/acel.12562 · Cited by 367

Historical claims and current interpretations of replicative aging

Wright, W. E., & Shay, J. W. (2002) · Nature Biotechnology · doi:10.1038/nbt0702-682 · Cited by 355

Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again

Forsyth, N. R., Wright, W. E., & Shay, J. W. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.690412.x · Cited by 345

Mechanisms of cellular senescence in human and mouse cells.

Itahana, K., Campisi, J., & Dimri, G. P. (2004) · Biogerontology · doi:10.1023/b:bgen.0000017682.96395.10 · Cited by 338

A Two-Stage, p16 INK4A - and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

Rheinwald, J. G., Hahn, W. C., Ramsey, M. R., Wu, J. Y., Guo, Z., Tsao, H., De Luca, M., Catricalà, C., & O'Toole, K. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5157-5172.2002 · Cited by 338

Telomeres: Cancer to Human Aging

Stewart, S. A., & Weinberg, R. A. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104518 · Cited by 349

T Cell Replicative Senescence in Human Aging

P. Chou, J., & B. Effros, R. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219711 · Cited by 323

Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease

Savale, L., Chaouat, A., Bastuji‐Garin, S., Marcos, É., Boyer, L., Maître, B., Sarni, M., HOUSSET, B., Weitzenblum, E., Matrat, M., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200809-1398oc · Cited by 329

What has senescence got to do with cancer?

Dimri, G. P. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.025 · Cited by 323

Amplification of Mdmx (or Mdm4 ) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

Danovi, D., Meulmeester, E., Pasini, D., Migliorini, D., Capra, M., Frenk, R., de Graaf, P., Francoz, S., Gasparini, P., Gobbi, A., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5835-5843.2004 · Cited by 310

Cell senescence and cancer

Mathon, N. F., & Lloyd, A. C. (2001) · Nature reviews. Cancer · doi:10.1038/35106045 · Cited by 313

A High Glycolytic Flux Supports the Proliferative Potential of Murine Embryonic Stem Cells

Kondoh, H., Lleonart, M. E., Nakashima, Y., Yokode, M., Tanaka, M., Bernard, D., Gil, J., & Beach, D. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.1467 · Cited by 325

Cellular senescence as a tumor-protection mechanism: the essential role of counting

Wright, W. E., & Shay, J. W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00163-5 · Cited by 306

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

Akbar, A. N., Henson, S. M., & Lanna, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.002 · Cited by 285

Constitutive Human Telomerase Reverse Transcriptase Expression Enhances Regenerative Properties of Endothelial Progenitor Cells

Murasawa, S., Llevadot, J., Silver, M., Isner, J. M., Losordo, D. W., & Asahara, T. (2002) · Circulation · doi:10.1161/01.cir.0000027584.85865.b4 · Cited by 303

MafB/c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages

Aziz, A., Soucie, E., Sarrazin, S., & Sieweke, M. H. (2009) · Science · doi:10.1126/science.1176056 · Cited by 317

The genetics of malignant melanoma: lessons from mouse and man

Chin, L. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1145 · Cited by 312

Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin‐dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies

Zhu, C., Mouly, V., Cooper, R. N., Mamchaoui, K., Bigot, A., Shay, J. W., Santo, J. P. D., Butler-Browne, G. S., & Wright, W. E. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00306.x · Cited by 301

Senescence, apoptosis and therapy — cutting the lifelines of cancer

Schmitt, C. A. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1044 · Cited by 295

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

Cao, L., Li, W., Kim, S., Brodie, S. G., & Deng, C.-X. (2003) · Genes & Development · doi:10.1101/gad.1050003 · Cited by 293

Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

Ferbeyre, G., de Stanchina, E., Lin, A. W., Querido, E., McCurrach, M. E., Hannon, G. J., & Lowe, S. W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3497-3508.2002 · Cited by 290

Aging of the cells: Insight into cellular senescence and detection Methods.

Mohamad Kamal, N. S., Safuan, S., Shamsuddin, S., & Foroozandeh, P. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2020.151108 · Cited by 287

Id proteins in cell cycle control and cellular senescence

Zebedee, Z., & Hara, E. (2001) · Oncogene · doi:10.1038/sj.onc.1205092 · Cited by 281

Oncogene-Induced Senescence: Putting the Brakes on Tumor Development

Braig, M., & Schmitt, C. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4006 · Cited by 274

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

Johnson, F. B., Marciniak, R. A., McVey, M., Stewart, S. A., Hahn, W. C., & Guarente, L. (2001) · The EMBO Journal · doi:10.1093/emboj/20.4.905 · Cited by 269

From cells to organisms: can we learn about aging from cells in culture?

Campisi, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00230-8 · Cited by 267

Cellular senescence in vivo: a barrier to tumorigenesis

Prieur, A., & Peeper, D. S. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.007 · Cited by 260

Integrating Old and New Paradigms of G1/S Control

Rubin, S. M., Sage, J., & Skotheim, J. M. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.08.020 · Cited by 283

Immortalization and transformation of primary human airway epithelial cells by gene transfer

Lundberg, A. S., Randell, S. H., Stewart, S. A., Elenbaas, B., Hartwell, K. A., Brooks, M. W., Fleming, M. D., Olsen, J. C., Miller, S. W., Weinberg, R. A., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205550 · Cited by 263

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

Chua, K. F., Mostoslavsky, R., Lombard, D. B., Pang, W. W., Saito, S., Franco, S., Kaushal, D., Cheng, H.-L., Fischer, M. R., Stokes, N., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.007 · Cited by 258

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

Poggetto, E. D., Ho, I.-L., Balestrieri, C., Yen, E.-Y., Zhang, S., Citron, F., Shah, R., Corti, D., Diaferia, G. R., Li, C.-Y., et al. (2021) · Science · doi:10.1126/science.abj0486 · Cited by 259

Oncogene-induced senescence: the bright and dark side of the response

Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.07.013 · Cited by 257

Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53

Dirac, A. M. G., & Bernards, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300023200 · Cited by 265

Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.

Fischer, M., & Müller, G. A. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1360836 · Cited by 255

Cellular senescence and cancer treatment

Schmitt, C. A. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.005 · Cited by 254

Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis

O’Donnell, K. A., Yu, D., Zeller, K. I., Kim, J., Racke, F. K., Thomas‐Tikhonenko, A., & Dang, C. V. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2373-2386.2006 · Cited by 251

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

Young, A. P., Schlisio, S., Minamishima, Y. A., Zhang, Q., Li, L., Grisanzio, C., Signoretti, S., & Kaelin, W. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1699 · Cited by 239

Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis

Werner, C., Hanhoun, M., Widmann, T., Kazakov, A., Semenov, A., Pöss, J., Bauersachs, J., Thum, T., Pfreundschuh, M., Müller, P., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.04.034 · Cited by 239

A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells

Kato, M. V., Arce, L., Wang, M., Putta, S., Lanting, L. L., & Natarajan, R. D. (2011) · Kidney International · doi:10.1038/ki.2011.43 · Cited by 238

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

Müller, M. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2104 · Cited by 243

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer

Tschaharganeh, D. F., Xue, W., Calvisi, D. F., Evert, M., Michurina, T. V., Dow, L. E., Banito, A., Katz, S. F., Kastenhuber, E. R., Weissmueller, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.051 · Cited by 227

Telomeres, aging and cancer: In search of a happy ending

Kim, S.-H., Kaminker, P. G., & Campisi, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205077 · Cited by 234

Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor Cells

Tang, D. G., Tokumoto, Y. M., Apperly, J. A., Lloyd, A. C., & RAFF, M. C. (2001) · Science · doi:10.1126/science.1056780 · Cited by 227

Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a

Alani, R. M., Young, A. Z., & Shifflett, C. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141235398 · Cited by 231

The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis

Sharpless, N. E., Ramsey, M. R., Balasubramanian, P., Castrillon, D. H., & DePinho, R. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207074 · Cited by 224

Cell cycle arrest is not senescence

Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100281 · Cited by 217

Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes

Campisi, J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00152-3 · Cited by 218

Mechanisms of cellular senescence in human and mouse cells.

Itahana, K., Campisi, J., & Dimri, G. P. (2004) · Biogerontology · doi:10.1023/b:bgen.0000017682.96395.10 · Cited by 338

Replicative senescence: a critical review

Cristofalo, V. J., Lorenzini, A., Allen, R. G., Torres, C. A., & Tresini, M. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.010 · Cited by 285

A Comparison of Senescence in Mouse and Human Cells

Gorbunova, V. A., & Seluanov, A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1075-2_7 · Cited by 2

The role of replicative senescence in cancer and human ageing: utility (or otherwise) of murine models

Smith, S. K., & Kipling, D. (2004) · Cytogenetic and Genome Research · doi:10.1159/000078219 · Cited by 17

Molecular Mechanisms of Cellular Senescence

Becker, T. M., & Haferkamp, S. (2013) · InTech eBooks · doi:10.5772/54120 · Cited by 17