Cited by 751Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

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Cellular Senescence

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Sherr, Charles J, DePinho, Ronald A·2000·Cell

DOI 10.1016/s0092-8674(00)00046-5

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The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
The serial cultivation of human diploid cell strains
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“…same panoply of cell cycle regulatory proteins nortemptation has been to link conclusions drawn from mally associated with arresting cells and undergo “prestudies in these different cell systems, equating senes- mature senescence” (Serrano et al., 1997), whereas escence in mouse and human cells.”
Background
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES
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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
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Self-citation
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566
Self-citation
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development · doi:10.1101/gad.12.15.2424 · Cited by 1,245
Self-citation
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206 · cited 1×
“Removing the telomerements TERT reconstitution in the immortalization pro- cess (Kiyono et al., 1998).”
Background
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086

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Authors: Sherr, C. J., & DePinho, R. A.
Affiliations: St. Jude Children's Research Hospital (US)
Harvard University (US)
Corresponding author: Sherr, Charles J
ORCID: Sherr, Charles J
DePinho, Ronald A
Venue: Cell
Publisher: Elsevier BV
Published: 2000-08
Volume: 102
Issue: 4
Pages: 407-410
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)00046-5
OpenAlex: W2324248025
Cited by: 745
References: 20
Citations by year: 2026: 6 · 2025: 5 · 2024: 13 · 2023: 10 · 2022: 13 · 2021: 19 · 2020: 20 · 2019: 16 · 2018: 7 · 2017: 30 · 2016: 17 · 2015: 19 · 2014: 24 · 2013: 19 · 2012: 31
FWCI: 36.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4764 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: cellular senescence, biological aging, human fibroblasts, mouse fibroblasts, culture shock, telomere integrity, cell cycle inhibitors, oncogenic transformation, chromosome stability
MeSH terms: Animals, Humans, Mitosis, Models, Biological, Telomere, Cellular Senescence

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