Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

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Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

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Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint

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The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

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The Atlas of Mouse Development

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Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

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Adipogenesis and Obesity: Rounding Out the Big Picture

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Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint

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Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

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PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation

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Tumor suppressor activity of RUNX3

Bae, S., & Choi, J.-K. (2004) · Oncogene · doi:10.1038/sj.onc.1207286 · Cited by 128

Molecular regulation of tooth development

Thesleff, I., & Åberg, T. (1999) · Bone · doi:10.1016/s8756-3282(99)00119-2 · Cited by 127

Phenotypic Changes in Dentition of Runx2 Homozygote-null Mutant Mice

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FGF2-activated ERK Mitogen-activated Protein Kinase Enhances Runx2 Acetylation and Stabilization

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Positionally-dependent chondrogenesis induced by BMP4 is co-regulated by sox9 and msx2

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Flow perfusion culture of human mesenchymal stem cells on silicate-substituted tricalcium phosphate scaffolds

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Sequential and Opposing Activities of Wnt and BMP Coordinate Zebrafish Bone Regeneration

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The osteogenic differentiation of SSEA-4 sub-population of human adipose derived stem cells using silicate nanoplatelets

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The Role of the Bone Marrow Microenvironment in the Pathophysiology of Myeloma and Its Significance in the Development of More Effective Therapies

Mitsiades, C. S., McMillin, D. W., Klippel, S., Hideshima, T., Chauhan, D., Richardson, P. G. G., Munshi, N. C., & Anderson, K. C. (2007) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2007.08.007 · Cited by 125

Epigallocatechin-3-gallate increases the formation of mineralized bone nodules by human osteoblast-like cells

Vali, B., Rao, L. G., & El‐Sohemy, A. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.06.005 · Cited by 125

Differentiation plasticity of chondrocytes derived from mouse embryonic stem cells

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Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP‐2

Viñals, F., López‐Rovira, T., Rosa, J. L., & Ventura, F. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03236-7 · Cited by 125

Development and Characterization of Conditionally Immortalized Osteoblast Precursor Cell Lines from Human Bone Marrow Stroma

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Signaling network regulating osteogenesis in mesenchymal stem cells

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Vascular calcification: expression patterns of the osteoblast-specific gene core binding factor α-1 and the protective factor matrix gla protein in human atherogenesis

Engelse, M. A. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00375-3 · Cited by 124

Chondrocytes Provide Morphogenic Signals That Selectively Induce Osteogenic Differentiation of Mesenchymal Stem Cells

Gerstenfeld, L. C., Cruceta, J., Shea, C. M., Sampath, K. T., Barnes, G. B., & Einhorn, T. A. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.2.221 · Cited by 124

p38 Regulates Expression of Osteoblast-specific Genes by Phosphorylation of Osterix

Ortuño, M. J., Ruiz-Gaspà, S., Rodríguez-Carballo, E., Susperregui, A. R. G., Bartrons, R., Rosa, J. L., & Ventura, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123612 · Cited by 123

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues

Ehlen, H. W. A., Chinenkova, M., Moser, M., Munter, H.-M., Krause, Y., Groß, S., Brachvogel, B., Wuelling, M., Kornak, U., & Vortkamp, A. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1751 · Cited by 122

FGF-2 Inhibits Osteogenesis in Mouse Adipose Tissue-Derived Stromal Cells and Sustains their Proliferative and Osteogenic Potential State

Quarto, N., & Longaker, M. T. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.1405 · Cited by 123

Surface modifications of dental implants

Stanford, C. (2008) · Australian Dental Journal · doi:10.1111/j.1834-7819.2008.00038.x · Cited by 123

CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neuronsPreprint

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Effects of Interleukin-17A on Osteogenic Differentiation of Isolated Human Mesenchymal Stem Cells

Osta, B., Lavocat, F., Eljaafari, A., & Miossec, P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00425 · Cited by 127

An ELISA-based method to quantify osteocalcin carboxylation in mice

Ferron, M., Wei, J., Yoshizawa, T., Ducy, P. F., & Karsenty, G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.008 · Cited by 120

Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification

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Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK ‐dependent manner

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Advances in Defining Regulators of Cementum Development and Periodontal Regeneration

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Genetic evidence for the vital function of osterix in cementogenesis

Cao, Z., Zhang, H., Zhou, X., Han, X., Ren, Y., Gao, T., Xiao, Y., Crombrugghe, B. D., Somerman, M. J., & Feng, J. Q. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1552 · Cited by 122

Dexamethasone Enhances In Vitro Vascular Calcification by Promoting Osteoblastic Differentiation of Vascular Smooth Muscle Cells

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Eph Receptors and Ephrin Signaling Pathways: A Role in Bone Homeostasis

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Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair

Stein, G. S., Zaidi, S. K., Braastad, C. D., Montecino, M. A., van Wijnen, A. J., Choi, J., Stein, J. L., Lian, J. B., & Javed, A. (2003) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.09.009 · Cited by 122

Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases

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Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation

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Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

Weske, S., Vaidya, M., Reese, A., Lipinski, K. V. W., Keul, P., Bayer, J. K., Fischer, J. W., Flögel, U., Nelsen, J., Epple, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0005-y · Cited by 121

In vitro and in vivo evidence for orphan nuclear receptor RORα function in bone metabolism

Meyer, T., Kneissel, M., Mariani, J., & Fournier, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150246097 · Cited by 123

Increased adipogenesis of osteoporotic human‐mesenchymal stem cells (MSCs) characterizes by impaired leptin action

Astudillo, P., Ríos, S., Pastenes, L., Pino, A. M., & Rodríguez, J. P. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21516 · Cited by 121

Biomolecular Mechanisms of Calvarial Bone Induction: Immature versus Mature Dura Mater

Greenwald, J. A., Mehrara, B. J., Spector, J. A., Chin, G. S., Steinbrech, D. S., Saadeh, P. B., Luchs, J. S., Paccione, M. F., Gittes, G. K., & Longaker, M. T. (2000) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200004040-00018 · Cited by 121

Roles of FGF receptors in mammalian development and congenital diseases

Coumoul, X., & Deng, C. (2003) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.10025 · Cited by 121

Conditional deletion of Indian hedgehog from collagen type 2α1‐expressing cells results in abnormal endochondral bone formation

Razzaque, M. S., Soegiarto, D. W., Chang, D., Long, F., & Lanske, B. (2005) · The Journal of Pathology · doi:10.1002/path.1870 · Cited by 121

Endogenous Msx1 antisense transcript: In vivo and in vitro evidences, structure, and potential involvement in skeleton development in mammals

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Is Wnt signalling the final common pathway leading to bone formation?

Milat, F., & Ng, K. W. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.06.002 · Cited by 123

Generation of Multipotential Mesendodermal Progenitors from Mouse Embryonic Stem Cells via Sustained Wnt Pathway Activation

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Epidermal Growth Factor Receptor-deficient Mice Have Delayed Primary Endochondral Ossification Because of Defective Osteoclast Recruitment

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The skeleton: a multi-functional complex organ. New insights into osteoblasts and their role in bone formation: the central role of PI3Kinase

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Bone Morphogenetic Protein 2 Mediates Dentin Sialophosphoprotein Expression and Odontoblast Differentiation via NF-Y Signaling

Chen, S., Gluhak‐Heinrich, J., Martı́nez, M., Li, T., Wu, Y., Chuang, H.-H., Chen, L., Dong, J., Gay, I. C., & MacDougall, M. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709492200 · Cited by 119

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

Bosselut, R. (2004) · Nature reviews. Immunology · doi:10.1038/nri1392 · Cited by 123

The Orphan Nuclear Estrogen Receptor–Related Receptor α (Errα) Is Expressed Throughout Osteoblast Differentiation and Regulates Bone Formation in Vitro

Bonnelye, E., Merdad, L., Kung, V., & Aubin, J. E. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.971 · Cited by 119

Multiplicity of BMP Signaling in Skeletal Development

Wu, X., Shi, W., & Cao, X. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.053 · Cited by 122

Transforming Growth Factor-β1 Regulation of Collagenase-3 Expression in Osteoblastic Cells by Cross-talk between the Smad and MAPK Signaling Pathways and Their Components, Smad2 and Runx2

Selvamurugan, N., Kwok, S., Alliston, T. N., Reiß, M., & Partridge, N. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314048200 · Cited by 119

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription

Wang, W., Lian, N., Li, L., Moss, H. E., Wang, W., Perrien, D. S., Elefteriou, F., & Yang, X. (2009) · Development · doi:10.1242/dev.043281 · Cited by 119

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors.

Sun, W., & Downing, J. R. (2004) · Blood · doi:10.1182/blood-2003-12-4349 · Cited by 118

The RUNX family in breast cancer: relationships with estrogen signaling

Chimge, N.-O., & Frenkel, B. (2012) · Oncogene · doi:10.1038/onc.2012.328 · Cited by 122

Adult human neural crest–derived cells for articular cartilage repair

Pelttari, K., Pippenger, B. E., Mumme, M., Feliciano, S., Scotti, C., Mainil‐Varlet, P., Procino, A., von Rechenberg, B., Schwamborn, T., Jakob, M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009688 · Cited by 118

Transcriptional Regulation of Osteoblasts

Franceschi, R. T., Ge, C., Xiao, G., Roca, H., & Jiang, D. (2008) · Cells Tissues Organs · doi:10.1159/000151747 · Cited by 118

The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro

Pan, B.-Q., To, L. B., Farrugia, A. N., Findlay, D. M., Green, J., Gronthos, S., Evdokiou, A., Lynch, K., Atkins, G. J., & Zannettino, A. C. W. (2003) · Bone · doi:10.1016/j.bone.2003.08.013 · Cited by 117

Inflammation and Vascular Calcification

Moe, S. M., & Chen, N. X. (2004) · Blood Purification · doi:10.1159/000082013 · Cited by 118

Young Women with Cold-Activated Brown Adipose Tissue Have Higher Bone Mineral Density and Lower Pref-1 than Women without Brown Adipose Tissue: A Study in Women with Anorexia Nervosa, Women Recovered from Anorexia Nervosa, and Normal-Weight Women

Bredella, M. A., Fazeli, P. K., Freedman, L. M., Calder, G. L., Lee, H., Rosen, C. J., & Klibanski, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2246 · Cited by 120

Development of Stepwise Osteogenesis-mimicking Matrices for the Regulation of Mesenchymal Stem Cell Functions

Hoshiba, T., Kawazoe, N., Tateishi, T., & Chen, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.054676 · Cited by 118

Molecular pathology of vertebral deformities in hyperthermic Atlantic salmon (Salmo salar)

Ytteborg, E., Bæverfjord, G., Torgersen, J. S., Hjelde, K., & Takle, H. (2010) · BMC Physiology · doi:10.1186/1472-6793-10-12 · Cited by 118

Simvastatin antagonizes tumor necrosis factor-α inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway

Yamashita, M., Otsuka, F., Mukai, T., Otani, H., Inagaki, K., Miyoshi, T., Goto, J., Yamamura, M., & Makino, H. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0532 · Cited by 120

Bone Morphogenetic Protein 2 Induces Cyclo-oxygenase 2 in Osteoblasts via a Cbfa1 Binding Site: Role in Effects of Bone Morphogenetic Protein 2 In Vitro and In Vivo

Chikazu, D., Li, X., Kawaguchi, H., Sakuma, Y., Voznesensky, O. S., Adams, D. J., Xu, M., Hoshi, K., Katavić, V., Herschman, H. R., et al. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.8.1430 · Cited by 118

EBF2 Regulates Osteoblast-Dependent Differentiation of Osteoclasts

Kieslinger, M., Roessler, S. K., Dobreva, G. D., Dorn, T., Croci, L., Erben, R. G., Consalez, G. G., & Grosschedl, R. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.10.009 · Cited by 120

Gene expression changes during mouse skeletal myoblast differentiation revealed by transcriptional profiling

Moran, J. L., Li, Y., Hill, A. A. V., Mounts, W. M., & Miller, C. P. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00011.2002 · Cited by 117

Successful Mandibular Reconstruction Using a BMP Bioimplant

Moghadam, H., Urist, M. R., Sándor, G. K. B., & Clokie, C. M. L. (2001) · Journal of Craniofacial Surgery · doi:10.1097/00001665-200103000-00005 · Cited by 118

Mechanisms of bone anabolism regulated by statins

Ruan, F., Zheng, Q., & Wang, J. (2012) · Bioscience Reports · doi:10.1042/bsr20110118 · Cited by 117

Cytotoxicity and osteogenic potential of silicate calcium cements as potential protective materials for pulpal revascularization

Bortoluzzi̇, E. A., Niu, L., Palani, C. D., El‐Awady, A., Hammond, B. D., Pei, D.-D., Tian, F., Cutler, C. W., Pashley, D. H., & Tay, F. R. (2015) · Dental Materials · doi:10.1016/j.dental.2015.09.020 · Cited by 117

Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates

Mundell, N. A., & Labosky, P. A. (2011) · Development · doi:10.1242/dev.054718 · Cited by 116

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Li, X., Huang, M., Zheng, H., Wang, Y., Ren, F., Shang, Y., Zhai, Y., Irwin, D. M., Shi, Y., Chen, D., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711044 · Cited by 117

Molecular bases of the crosstalk between bone and muscle

Karsenty, G., & Mera, P. (2017) · Bone · doi:10.1016/j.bone.2017.04.006 · Cited by 121

Cyclin D1-Cdk4 Induce Runx2 Ubiquitination and Degradation

Shen, R., Wang, X., Drissi, H., Liu, F., O’Keefe, R. J., & Chen, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603439200 · Cited by 117

Combinatorial gene therapy for bone regeneration: Cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7

Zhao, M., Zhao, Z., Koh, J., Jin, T., & Franceschi, R. T. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20411 · Cited by 117

EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and osterix

Zhu, J., Shimizu, E., Zhang, X., Partridge, N. C., & Qin, L. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23094 · Cited by 116

The interrelationship between bone and fat: from cellular see-saw to endocrine reciprocity

Gijsen, H. S., Crowther, N. J., Hough, F. S., & Ferris, W. F. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1211-2 · Cited by 115

Osteogenic signaling on silk-based matrices

Midha, S., Murab, S., & Ghosh, S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.04.020 · Cited by 116

Regulation of Runx2 by MicroRNAs in osteoblast differentiation

Narayanan, A. M., Srinaath, N., Rohini, M., & Selvamurugan, N. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116676 · Cited by 119

Osteoimmunology: cytokines and the skeletal system

Lee, S., Kim, T. S., Choi, Y., & Lorenzo, J. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.7.495 · Cited by 117

Biglycan Modulates Osteoblast Differentiation and Matrix Mineralization

Parisuthiman, D., Mochida, Y., Duarte, W. R., & Yamauchi, M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050612 · Cited by 116

Expression of the PEBP2αA/AML3/CBFA1 Gene is Regulated by BMP4/7 Heterodimer and Its Overexpression Suppresses Type I Collagen and Osteocalcin Gene Expression in Osteoblastic and Nonosteoblastic Mesenchymal Cells

Tsuji, K., Ito, Y., & Noda, M. (1998) · Bone · doi:10.1016/s8756-3282(97)00267-6 · Cited by 117

Osteogenesis of Adipose-Derived Stem Cells

Grottkau, B. E., & Lin, Y. (2013) · Bone Research · doi:10.4248/br201302003 · Cited by 117

Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways

Tang, C.-Y., Wu, M., Zhao, D., Edwards, D. N., McVicar, A., Luo, Y., Zhu, G., Wang, Y., Zhou, H., Chen, W., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009233 · Cited by 112

Cell Cycle-dependent Phosphorylation of the RUNX2 Transcription Factor by cdc2 Regulates Endothelial Cell Proliferation

Qiao, M., Shapiro, P. S., Fosbrink, M. D., Rus, H., Kumar, R., & Passaniti, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508162200 · Cited by 114

Cell-Type-Dependent Up-Regulation of In Vitro Mineralization After Overexpression of the Osteoblast-Specific Transcription Factor Runx2/Cbfa1

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Microgravity: the immune response and bone

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