The DOI matches its Crossref record; 40 of the 43 references it cites were found in a registry or an index.
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Open accessAbstract
The osteoblast is the bone-forming cell. The molecular basis of osteoblast-specific gene expression and differentiation is unknown. We previously identified an osteoblast-specific cis-acting element, termed OSE2, in the Osteocalcin promoter. We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2. Osf2/Cbfa1 expression is initiated in the mesenchymal condensations of the developing skeleton, is strictly restricted to cells of the osteoblast lineage thereafter, and is regulated by BMP7 and vitamin D3. Osf2/Cbfa1 binds to and regulates the expression of multiple genes expressed in osteoblasts. Finally, forced expression of Osf2/Cbfa1 in nonosteoblastic cells induces the expression of the principal osteoblast-specific genes. This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation.
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“Gene deletion studies have shown that absence of runt-related transcription factor 2 (Runx2) or a downstream factor, osterix, are critical for osteoblast differentiation”
From Pathogenesis of osteoporosis: concepts, conflicts, and prospects (2005) · cites this paper as [55]
In the citing paper
“Additionally, Runx2 is a master gene of osteoblast differentiation, as demonstrated by the fact that Runx2-null mice are devoid of osteoblasts [26, 27].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [26]
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Metadata
- Authors
- Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Karsenty, Gérard
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 89
- Issue
- 5
- Pages
- 747-754
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1994596418
- Cited by
- 4,246
- References
- 43
- Citations by year
- 2026: 40 · 2025: 46 · 2024: 59 · 2023: 83 · 2022: 93 · 2021: 106 · 2020: 137 · 2019: 148 · 2018: 123 · 2017: 176 · 2016: 153 · 2015: 175 · 2014: 184 · 2013: 198 · 2012: 198
- FWCI
- 34.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (DE11290, R01DE011290)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- osteogenic differentiation, transcription factors, osteocalcin promoter, osteoblast-specific gene expression, BMP-7, vitamin D3, mesenchymal condensation, skeletal development, osteoblast lineage
- MeSH terms
- Amino Acid Sequence, Animals, Cell Differentiation, Cloning, Molecular, Molecular Sequence Data, Neoplasm Proteins, Osteoblasts, Promoter Regions, Genetic, Transcription Factors, Trans-Activators, Osteocalcin, Cell Adhesion Molecules, DNA, Complementary, Gene Expression Regulation, Developmental, Core Binding Factor Alpha 1 Subunit, Mice
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