Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

Luo, G., Ducy, P. F., McKee, M. D., Pinero, G. J., Loyer, E. M., Behringer, R. R., & Karsenty, G. (1997) · Nature · doi:10.1038/386078a0 · Cited by 2,118

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint

Hogan, B. L. M. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,964

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint

Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80986-1 · Cited by 1,856

The Atlas of Mouse Development

Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,750

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S. G., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,502

Adipogenesis and Obesity: Rounding Out the Big Picture

Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,262

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint

Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

Piccolo, S., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Cell · doi:10.1016/s0092-8674(00)80132-4 · Cited by 1,127

Structure and Development of the Skeleton

Marks, S. C., & Odgren, P. R. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50103-7 · Cited by 194

Reciprocal Roles of Msx2 in Regulation of Osteoblast and Adipocyte Differentiation

Ichida, F., Nishimura, R., Hata, K., Matsubara, T., Ikeda, F., Hisada, K., Yatani, H., Cao, X., Komori, T., Yamaguchi, A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403621200 · Cited by 173

The Vitamin D Receptor, Runx2, and the Notch Signaling Pathway Cooperate in the Transcriptional Regulation of Osteopontin

Shen, Q., & Christakos, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504166200 · Cited by 173

Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin

Balogh, E., Szilágyi-Tolnai, E., Nagy, B., Nagy, B., Balla, G., Balla, J., & Jeney, V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.06.003 · Cited by 176

1,25-(OH)2-Vitamin D3 Suppresses the Bone-Related Runx2/Cbfa1 Gene Promoter

Drissi, H. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5474 · Cited by 173

Differential Regulation of Dentin Sialophosphoprotein Expression by Runx2 during Odontoblast Cytodifferentiation

Chen, S., Rani, S., Wu, Y., Unterbrink, A., Gu, T. T., Gluhak‐Heinrich, J., Chuang, H.-H., & MacDougall, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502929200 · Cited by 172

Bone Morphogenetic Protein 2 Induces Dental Follicle Cells to Differentiate Toward a Cementoblast/Osteoblast Phenotype

Zhao, M., Xiao, G., Berry, J. E., Franceschi, R. T., Reddi, A. H., & Somerman, M. J. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.8.1441 · Cited by 172

The molecular mechanism behind bone remodelling: a review

Proff, P., & Römer, P. (2009) · Clinical Oral Investigations · doi:10.1007/s00784-009-0268-2 · Cited by 183

Runx2-Upregulated Receptor Activator of Nuclear Factor κB Ligand in Calcifying Smooth Muscle Cells Promotes Migration and Osteoclastic Differentiation of Macrophages

Byon, C. H., Sun, Y., Chen, J., Yuan, K., Mao, X., Heath, J. M., Anderson, P. G., Tintut, Y., Demer, L. L., Wang, D., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.222547 · Cited by 172

An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice

Takarada, T., Hinoi, E., Nakazato, R., Ochi, H., Xu, C., Tsuchikane, A., Takeda, S., Karsenty, G., Abe, T., Kiyonari, H., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1945 · Cited by 172

Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio

Kiviranta, R., Morko, J. P., Alatalo, S. L., NicAmhlaoibh, R., Risteli, J., Laitala‐Leinonen, T., & VUORIO, E. I. (2004) · Bone · doi:10.1016/j.bone.2004.09.020 · Cited by 169

Bone formation via cartilage models: The “borderline” chondrocyte

Bianco, P., Cancedda, F. D., Riminucci, M., & Cancedda, R. (1998) · Matrix Biology · doi:10.1016/s0945-053x(98)90057-9 · Cited by 172

Parathyroid Hormone Regulates the Rat Collagenase-3 Promoter in Osteoblastic Cells through the Cooperative Interaction of the Activator Protein-1 Site and the runt Domain Binding Sequence

Selvamurugan, N., Chou, W., Pearman, A. T., Pulumati, M. R., & Partridge, N. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10647 · Cited by 170

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation

Zhao, M., Harris, S. E., Horn, D., Geng, Z., Nishimura, R., Mundy, G. R., & Chen, D. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200109012 · Cited by 171

Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases

Amarasekara, D. S., Yu, J., & Rho, J. (2015) · Journal of Immunology Research · doi:10.1155/2015/832127 · Cited by 177

Dose-Dependent Osteogenic Effect of Octacalcium Phosphate on Mouse Bone Marrow Stromal Cells

Anada, T., Kumagai, T., Honda, Y., Masuda, T., Kamijo, R., Kamakura, S., Yoshihara, N., Kuriyagawa, T., Shimauchi, H., & Suzuki, O. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0339 · Cited by 170

miR‐21 modulates the ERK–MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation

Yang, M., Bian, C., Li, J., Du, Z., Zhou, H., Yang, Z., & Zhao, R. C. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24479 · Cited by 169

Conditional expression of a G i -coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy

Redfern, C. H., Degtyarev, M. Y., Kwa, A. T., Salomonis, N., de la Cotte, N., Nanevicz, T., Fidelman, N., Desai, K. H., VRANIZAN, K. M., Lee, E. K., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4826 · Cited by 169

Role of RANKL–RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications

Kohli, S. S., & Kohli, V. S. (2011) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.83401 · Cited by 181

Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice

Halade, G. V., Jamali, A. E., Williams, P. J., Fajardo, R. J., & Fernandes, G. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.014 · Cited by 169

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis

Baniwal, S. K., Khalid, O. S., Gabet, Y., Shah, R., Purcell, D. J., Mav, D., Kohn-Gabet, A. E., Shi, Y., Coetzee, G. A., & Frenkel, B. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-258 · Cited by 172

Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription

Afzal, F., Pratap, J., Ito, K., Ito, Y., Stein, J. L., van Wijnen, A. J., Stein, G. S., Lian, J. B., & Javed, A. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20258 · Cited by 169

Osteotropic cancers: From primary tumor to bone

Buijs, J. T., & van der Pluijm, G. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.044 · Cited by 175

Postnatal Skeletal Stem Cells

Bianco, P., Kuznetsov, S. A., Riminucci, M., & Robey, P. G. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)19006-0 · Cited by 172

HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes

Hassan, M. Q., Tare, R. S., Lee, S. H., Mandeville, M., Weiner, B., Montecino, M. A., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01544-06 · Cited by 168

An important role for RUNX3 in human L1 transcription and retrotransposition

Yang, N. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg663 · Cited by 167

BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity

Jun, J. H., Yoon, W.-J., Seo, S.-B., Woo, K.-M., Kim, G.-S., Ryoo, H.-M., & Baek, J.-H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.142307 · Cited by 167

Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARγ2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures

Li, X. J., Cui, Q., Kao, C. H., Wang, G.-J., & Balian, G. (2003) · Bone · doi:10.1016/s8756-3282(03)00239-4 · Cited by 167

Long-chain polyunsaturated fatty acids: Selected mechanisms of action on bone

Kruger, M. C., Coetzee, M., Haag, M., & Weiler, H. A. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.06.002 · Cited by 173

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis

Zhang, F. S., Guo, X. Q., Xia, Y., & Mao, L. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04079-z · Cited by 177

The insulin-like growth factor-I gene and osteoporosis: A critical appraisal

Niu, T., & Rosen, C. J. (2005) · Gene · doi:10.1016/j.gene.2005.07.016 · Cited by 173

Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis

Okamoto, M., Udagawa, N., Uehara, S., Maeda, K., Yamashita, T., Nakamichi, Y., Kato, H., Saito, N., Minami, Y., Takahashi, N., et al. (2014) · Scientific Reports · doi:10.1038/srep04493 · Cited by 173

Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells

Stevens, J. R., Miranda‐Carboni, G. A., Singer, M. A., Brugger, S. M., Lyons, K. M., & Lane, T. F. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.118 · Cited by 166

The role of the Wnt signaling pathway in osteoblast commitment and differentiation

Yavropoulou, M. P., & Yovos, J. G. (2007) · HORMONES · doi:10.14310/horm.2002.1111024 · Cited by 170

Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblast differentiation and function

Smith, A. C., Avaron, F., Guay, D., Padhi, B. K., & Akimenko, M. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.016 · Cited by 166

Biomimetic Design of Mussel-Derived Bioactive Peptides for Dual-Functionalization of Titanium-Based Biomaterials

Pan, G., Sun, S., Zhang, W., Zhao, R., Cui, W., He, F., Huang, L., Lee, S.-H., Shea, K. J., Shi, Q., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b09770 · Cited by 166

Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture

Pereira, R. M. R., Delany, A. M., & CANALIS, E. M. (2001) · Bone · doi:10.1016/s8756-3282(01)00422-7 · Cited by 166

FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion

Zhang, H., Pan, Y., Zheng, L. W., Choe, C., Lindgren, B. R., Jensen, E. D., Westendorf, J. J., Liang Cheng, C., & Huang, H. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2603 · Cited by 167

Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells

Dai, Z., Wang, R., Ling, S., Wan, Y., & Li, Y. H. (2007) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00461.x · Cited by 165

Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss

Jeney, V. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00077 · Cited by 170

Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells

Byon, C. H., Heath, J. M., & Chen, Y. (2016) · Redox Biology · doi:10.1016/j.redox.2016.08.015 · Cited by 166

Physical Interaction of the Activator Protein-1 Factors c-Fos and c-Jun with Cbfa1 for Collagenase-3 Promoter Activation

DʼAlonzo, R. C., Selvamurugan, N., Karsenty, G., & Partridge, N. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107082200 · Cited by 164

Interleukin‐1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt‐5a/receptor tyrosine kinase–like orphan receptor 2 pathway

Sonomoto, K., Yamaoka, K., Oshita, K., Fukuyo, S., Zhang, X., Nakano, K., Okada, Y., & Tanaka, Y. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34555 · Cited by 163

Integrated Bone Tissue Physiology

Jee, W. S. S. (2001) · CRC Press eBooks · doi:10.1201/b14263-3 · Cited by 172

Bone metastatic LNCaP‐derivative C4‐2B prostate cancer cell line mineralizes in vitro

Lin, D., Tarnowski, C. P., Zhang, J., Dai, J., Rohn, E., Patel, A. H., Morris, M. D., & Keller, E. T. (2001) · The Prostate · doi:10.1002/pros.1065 · Cited by 163

Arterial calcification in diabetes

Chen, N. X., & Moe, S. M. (2003) · Current Diabetes Reports · doi:10.1007/s11892-003-0049-2 · Cited by 163

Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondriumPreprint

Hinoi, E., Bialek, P., Chen, Y., Rached, M.-T., Groner, Y., Behringer, R. R., Ornitz, D. M., & Karsenty, G. (2006) · Genes & Development · doi:10.1101/gad.1482906 · Cited by 163

A Positive Role of MicroRNA‐15b on Regulation of Osteoblast Differentiation

Vimalraj, S., Partridge, N. C., & Selvamurugan, N. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24557 · Cited by 162

Hydrostatic Pressure Enhances Chondrogenic Differentiation of Human Bone Marrow Stromal Cells in Osteochondrogenic Medium

Wagner, D. R., Lindsey, D. P., Li, K. W., Tummala, P., Chandran, S. E., Smith, R. L., Longaker, M. T., Carter, D. R. P., & Beaupré, G. S. (2008) · Annals of Biomedical Engineering · doi:10.1007/s10439-008-9448-5 · Cited by 162

Nrf2 Negatively Regulates Osteoblast Differentiation via Interfering with Runx2-dependent Transcriptional Activation

Hinoi, E., Fujimori, S., Wang, L., Hojo, H., Uno, K., & Yoneda, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600603200 · Cited by 162

Parathyroid Hormone Bone Anabolic Action Requires Cbfa1/Runx2-Dependent Signaling

Krishnan, V., Moore, T. L., Li, Y., Helvering, L. M., Frolik, C. A., Valasek, K. M., Ducy, P. F., & Geiser, A. G. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0225 · Cited by 162

Regulation of the osteoblast‐specific transcription factor Osterix by NO66, a Jumonji family histone demethylase

Sinha, K. M., Yasuda, H., Coombes, M. M., Dent, S., & Crombrugghe, B. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.332 · Cited by 160

Effects of mechanical strain on proliferation and differentiation of bone marrow stromal cell line ST2

Koike, M., Shimokawa, H., Kanno, Z., Ohya, K., & Soma, K. (2005) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-004-0587-y · Cited by 160

Role of Cbfa1 in osteoblast differentiation and function

Karsenty, G. (2000) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2000.0188 · Cited by 159

Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation

Li, B., Boast, S., Santos, K. D. L., Schieren, I., Quiroz, M. E., Teitelbaum, S. L., Tondravi, M. M., & Goff, S. P. (2000) · Nature Genetics · doi:10.1038/73542 · Cited by 160

Post-translational Regulation of Runx2 in Bone and Cartilage

Jonason, J. H., Xiao, G., Zhang, M., Xing, L., & Chen, D. (2009) · Journal of Dental Research · doi:10.1177/0022034509341629 · Cited by 160

Osteoblasts Directly Control Lineage Commitment of Mesenchymal Progenitor Cells through Wnt Signaling

Zhou, H., Mak, W., Zheng, Y., Dunstan, C. R., & Seibel, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702687200 · Cited by 160

Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains

Zeng, C., McNeil, S. M., Pockwinse, S. M., Nickerson, J. A., Shopland, L. S., Lawrence, J. B., Penman, S., Hiebert, S. W., Lian, J. B., van Wijnen, A. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1585 · Cited by 159

Dentin Matrix Protein 1, a Target Molecule for Cbfa1 in Bone, Is a Unique Bone Marker Gene

Feng, J. Q., Zhang, J., Dallas, S. L., Lu, Y., Chen, S., Tan, X., Owen, M. J., Harris, S. E., & MacDougall, M. J. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.10.1822 · Cited by 158

Amelogenin gene splice products: potential signaling molecules

Veis, A. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300003 · Cited by 158

Toward an understanding of implant occlusion and strain adaptive bone modeling and remodeling

Stanford, C. M., & Brand, R. A. (1999) · Journal of Prosthetic Dentistry · doi:10.1016/s0022-3913(99)70209-x · Cited by 161

Smad6 Interacts with Runx2 and Mediates Smad Ubiquitin Regulatory Factor 1-induced Runx2 Degradation

Shen, R., Chen, M., Wang, Y., Kaneki, H., Xing, L., O’Keefe, R. J., & Chen, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506761200 · Cited by 157

Reduction in Transforming Growth Factor β Receptor I Expression and Transcription Factor CBFa1 on Bone Cells by Glucocorticoid

Chang, D. J., Ji, C., Kim, K. K., Casinghino, S. R., & McCarthy, T. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.4892 · Cited by 157

Gene Transfer of the Runx2 Transcription Factor Enhances Osteogenic Activity of Bone Marrow Stromal Cells in Vitro and in Vivo

Zhao, Z., Zhao, M., Xiao, G., & Franceschi, R. T. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.03.009 · Cited by 156

Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice

Bartell, S. M., Rayalam, S., Ambati, S., Gaddam, D. R., Hartzell, D. L., Hamrick, M. W., She, J., Della‐Fera, M. A., & Baile, C. A. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.406 · Cited by 158

Functional Analysis of RUNX2 Mutations in Japanese Patients with Cleidocranial Dysplasia Demonstrates Novel Genotype-Phenotype Correlations

Yoshida, T., Kanegane, H., Osato, M., Yanagida, M., Miyawaki, T., Ito, Y., & Shigesada, K. (2002) · The American Journal of Human Genetics · doi:10.1086/342717 · Cited by 154

ERK Signaling Pathways Regulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells on Collagen I and Vitronectin

Salasznyk, R. M., Klees, R. F., Hughlock, M. K., & Plopper, G. E. (2004) · Cell Communication & Adhesion · doi:10.1080/15419060500242836 · Cited by 156

Bril: A Novel Bone-Specific Modulator of Mineralization

Moffatt, P., Gaumond, M.-H., Salois, P., Sellin, K., Bessette, M.-C., Godin, É., de Oliveira, P. T., Atkins, G. J., Nanci, A., & Thomas, G. P. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080412 · Cited by 158

LMP-1, A LIM-Domain Protein, Mediates BMP-6 Effects on Bone Formation

Boden, S. D., Liu, Y., Hair, G. A., Helms, J. A., Hu, D. P., Racine, M., Nanes, M. S., & Titus, L. (1998) · Endocrinology · doi:10.1210/endo.139.12.6392 · Cited by 155

Concise Review: Human Adipose-Derived Stem Cells: Separating Promise from Clinical Need

Locke, M., Feisst, V., & Dunbar, P. R. (2011) · Stem Cells · doi:10.1002/stem.593 · Cited by 154

Osteogenic Potential of Mandibular vs. Long-bone Marrow Stromal Cells

Aghaloo, T. L., Chaichanasakul, T., Bezouglaia, O., Kang, B., Franco, R., Dry, S., Atti, E., & Tetradis, S. (2010) · Journal of Dental Research · doi:10.1177/0022034510378427 · Cited by 154

GSK-3β Controls Osteogenesis through Regulating Runx2 Activity

Kugimiya, F., Kawaguchi, H., Ohba, S., Kawamura, N., Hirata, M., Chikuda, H., Azuma, Y., Woodgett, J. R., Nakamura, K., & Chung, U. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000837 · Cited by 156

Biomineralization in Humans: Making the Hard Choices in Life

Kawasaki, K., Buchanan, A. V., & Weiss, K. M. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134242 · Cited by 157

BMP Responsiveness in Human Mesenchymal Stem Cells

Diefenderfer, D. L., Osyczka, A. M., Reilly, G. C., & Leboy, P. S. (2003) · Connective Tissue Research · doi:10.1080/03008200390181825 · Cited by 154

Runx2 and dental development

Camilleri, S., & McDonald, F. (2006) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2006.00399.x · Cited by 153

Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene

Kitazawa, R., Kitazawa, S., & Maeda, S. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00032-9 · Cited by 153

Foxo1, a Novel Regulator of Osteoblast Differentiation and Skeletogenesis

Teixeira, C. C., Liu, Y., Thant, L. M., Pang, J., Palmer, G. D., & Alikhani, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.079962 · Cited by 150

SOX9 determines RUNX2 transactivity by directing intracellular degradation

Cheng, A., & Genever, P. G. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.174 · Cited by 151

Osteogenic activity and antibacterial effect of porous titanium modified with metal-organic framework films

Chen, J., Zhang, X., Huang, C., Cai, H., Hu, S., Wan, Q., Pei, X., & Wang, J. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35960 · Cited by 150

Regulation of adult bone turnover by sex steroids

Frenkel, B., Hong, A., Baniwal, S. K., Coetzee, G. A., Ohlsson, C., Khalid, O. S., & Gabet, Y. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22159 · Cited by 150

Menin Is Required for Bone Morphogenetic Protein 2- and Transforming Growth Factor β-regulated Osteoblastic Differentiation through Interaction with Smads and Runx2

Sowa, H., Kaji, H., Hendy, G. N., Canaff, L., Komori, T., Sugimoto, T., & Chihara, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401312200 · Cited by 149

Hypoxia, HIFs and bone development

Araldi, E., & Schipani, E. (2010) · Bone · doi:10.1016/j.bone.2010.04.606 · Cited by 153

N ew M olecules in the T umor N ecrosis F actor L igand and R eceptor S uperfamilies with I mportance for P hysiological and P athological B one R esorption

Lerner, U. H. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500202 · Cited by 147

A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis.

Matsubara, S., Wada, Y., Gardner, T. A., Egawa, M., Park, M. S., Hsieh, C., Zhau, H. E., Kao, C. H., Kamidono, S., Gillenwater, J. Y., et al. (2001) · PubMed · Cited by 149

Phosphorylation, acetylation and ubiquitination: The molecular basis of RUNX regulation

Bae, S., & Lee, Y. H. (2005) · Gene · doi:10.1016/j.gene.2005.10.017 · Cited by 148

Glucocorticoid-Induced Osteoporosis

Frenkel, B., White, W., & Tuckermann, J. P. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2895-8_8 · Cited by 154

Biomimetic cell culture proteins as extracellular matrices for stem cell differentiation.

Higuchi, A., Ling, Q.-D., Hsu, S.-T., & Umezawa, A. (2012) · Chemical Reviews · doi:10.1021/cr3000169 · Cited by 136

Molecular ontogeny of the skeleton

Eames, B. F., Fuente, L. D. L., & Helms, J. A. (2003) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.10016 · Cited by 148

Multilineage Differentiation of Cbfa1-Deficient Calvarial Cells in Vitro

Kobayashi, H., Gao, Y., Ueta, C., Yamaguchi, A., & Komori, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2981 · Cited by 148

Phosphophoryn Regulates the Gene Expression and Differentiation of NIH3T3, MC3T3-E1, and Human Mesenchymal Stem Cells via the Integrin/MAPK Signaling Pathway

Jadlowiec, J. A., Koch, H., Zhang, X., Campbell, P. G., Seyedain, M., & Sfeir, C. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404934200 · Cited by 148

Insulin-like Growth Factor-1 Regulates Endogenous RUNX2 Activity in Endothelial Cells through a Phosphatidylinositol 3-Kinase/ERK-dependent and Akt-independent Signaling Pathway

Qiao, M., Shapiro, P. S., Kumar, R., & Passaniti, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404480200 · Cited by 147

Nanotopographical Induction of Osteogenesis through Adhesion, Bone Morphogenic Protein Cosignaling, and Regulation of MicroRNAs

Yang, J., McNamara, L. E., Gadegaard, N., Alakpa, E. V., Burgess, K., Meek, R. M. D., & Dalby, M. J. (2014) · ACS Nano · doi:10.1021/nn504767g · Cited by 144

Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis

Carbonare, L. D., Valenti, M. T., Zanatta, M., Donatelli, L., & Cascio, V. L. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24884 · Cited by 145

Inflammation and Bone Metabolism in Rheumatoid Arthritis: Molecular Mechanisms of Joint Destruction and Pharmacological Treatments

Maeda, K., Yoshida, K., Nishizawa, T., Otani, K., Yamashita, Y., Okabe, H., Hadano, Y., Kayama, T., Kurosaka, D., & Saito, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052871 · Cited by 153

Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling.

Marie, P. J., Debiais, F., & Haÿ, E. (2002) · PubMed · doi:10.14670/hh-17.877 · Cited by 146

The Multifaceted Role of the Vasculature in Endochondral Fracture Repair

Bahney, C. S., Hu, D. P., Miclau, T., & Marcucio, R. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00004 · Cited by 146

Female Estrogen Receptor β−/− Mice Are Partially Protected Against Age-Related Trabecular Bone Loss

Windahl, S. H., Hollberg, K., Vidal, O., Gustafsson, J.-Α., Ohlsson, C., & Andersson, G. N. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.8.1388 · Cited by 146

Steroid effects on osteogenesis through mesenchymal cell gene expression

Li, X. J., Jin, L., Cui, Q., Wang, G., & Balian, G. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1649-7 · Cited by 146

Fidelity of Runx2 Activity in Breast Cancer Cells Is Required for the Generation of Metastases-Associated Osteolytic Disease

Barnes, G. B., Hebert, K. E., Kamal, M., Javed, A., Einhorn, T. A., Lian, J. B., Stein, G. S., & Gerstenfeld, L. C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3851 · Cited by 145

The Missing Bone

Rodan, G. A., & Harada, S.-I. (1997) · Cell · doi:10.1016/s0092-8674(00)80249-4 · Cited by 146

Transcriptional regulation of osteoblast differentiation during development

Karsenty, G. (1998) · Frontiers in bioscience · doi:10.2741/a326 · Cited by 39

Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis

Gofflot, F., Gaoua, W., Bourguignon, L., Roux, C., & Picard, J. J. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 27

Characterization of Osf1, an Osteoblast-specific Transcription Factor Binding to a Critical cis-acting Element in the MouseOsteocalcin Promoters

Schinke, T., & Karsenty, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30182 · Cited by 73

Mesenchymal Stem Cells and Osteoblast Differentiation

Aubin, J. E., & Triffitt, J. T. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50106-2 · Cited by 163

The Developmental Control of Osteoblast-Specific Gene Expression: Role of Specific Transcription Factors and the Extracellular Matrix Environment

Franceschi, R. T. (1999) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411990100010201 · Cited by 274