Cited by 4,246Bone Metabolism and DiseasesBone and Dental Protein StudiesDevelopmental Biology and Gene Regulation

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Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

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Ducy, Patricia, Zhang, Rui, Geoffroy, Valérie, Ridall, Amy L, Karsenty, Gérard·1997·Cell

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Abstract

The osteoblast is the bone-forming cell. The molecular basis of osteoblast-specific gene expression and differentiation is unknown. We previously identified an osteoblast-specific cis-acting element, termed OSE2, in the Osteocalcin promoter. We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2. Osf2/Cbfa1 expression is initiated in the mesenchymal condensations of the developing skeleton, is strictly restricted to cells of the osteoblast lineage thereafter, and is regulated by BMP7 and vitamin D3. Osf2/Cbfa1 binds to and regulates the expression of multiple genes expressed in osteoblasts. Finally, forced expression of Osf2/Cbfa1 in nonosteoblastic cells induces the expression of the principal osteoblast-specific genes. This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation.

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Authors: Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Karsenty, Gérard
ORCID: Ducy, Patricia
Zhang, Rui
Geoffroy, Valérie
Karsenty, Gérard
Venue: Cell
Publisher: Elsevier BV
Published: 1997-05
Volume: 89
Issue: 5
Pages: 747-754
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)80257-3
OpenAlex: W1994596418
Cited by: 4,246
References: 43
Citations by year: 2026: 40 · 2025: 46 · 2024: 59 · 2023: 83 · 2022: 93 · 2021: 106 · 2020: 137 · 2019: 148 · 2018: 123 · 2017: 176 · 2016: 153 · 2015: 175 · 2014: 184 · 2013: 198 · 2012: 198
FWCI: 34.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5921 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Dental and Craniofacial Research (DE11290, R01DE011290)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: osteogenic differentiation, transcription factors, osteocalcin promoter, osteoblast-specific gene expression, BMP-7, vitamin D3, mesenchymal condensation, skeletal development, osteoblast lineage
MeSH terms: Amino Acid Sequence, Animals, Cell Differentiation, Cloning, Molecular, Molecular Sequence Data, Neoplasm Proteins, Osteoblasts, Promoter Regions, Genetic, Transcription Factors, Trans-Activators, Osteocalcin, Cell Adhesion Molecules, DNA, Complementary, Gene Expression Regulation, Developmental, Core Binding Factor Alpha 1 Subunit, Mice

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Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

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