Cited by 4,246Bone Metabolism and DiseasesBone and Dental Protein StudiesDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 40 of the 43 references it cites were found in a registry or an index.

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Open access

Ducy, Patricia, Zhang, Rui, Geoffroy, Valérie, Ridall, Amy L, Karsenty, Gérard·1997·Cell

Open this paper in CoChat — free account Open PDF

Abstract

The osteoblast is the bone-forming cell. The molecular basis of osteoblast-specific gene expression and differentiation is unknown. We previously identified an osteoblast-specific cis-acting element, termed OSE2, in the Osteocalcin promoter. We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2. Osf2/Cbfa1 expression is initiated in the mesenchymal condensations of the developing skeleton, is strictly restricted to cells of the osteoblast lineage thereafter, and is regulated by BMP7 and vitamin D3. Osf2/Cbfa1 binds to and regulates the expression of multiple genes expressed in osteoblasts. Finally, forced expression of Osf2/Cbfa1 in nonosteoblastic cells induces the expression of the principal osteoblast-specific genes. This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(00)80257-3

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development
Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
Luo, G., Ducy, P. F., McKee, M. D., Pinero, G. J., Loyer, E. M., Behringer, R. R., & Karsenty, G. (1997) · Nature · doi:10.1038/386078a0 · Cited by 2,118
Self-citation
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint
Hogan, B. L. M. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,964
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint
Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.
Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80986-1 · Cited by 1,856
The Atlas of Mouse Development
Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,750
Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia
Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S. G., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,502
Adipogenesis and Obesity: Rounding Out the Big Picture
Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,262
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint
Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151
Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4
Piccolo, S., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Cell · doi:10.1016/s0092-8674(00)80132-4 · Cited by 1,127

Show all 43 references

Research works printed but not linked: 4

Aubin, J., and Liu, F. (1996). The osteoblast lineage. In Principles of Bone Biology, J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, eds. (San Diego, California: Academic Press), pp. 51–67.
Bae, 1992, Isolation of PEBP2αB cDNA representing the mouse homologue of human acute myeloid leukemia gene, Oncogene, 8, 809
Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, C. Nolan, ed. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
Sundin, 1990, Region-specific expression in early chick and mouse embryo of Ghox-lab and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila labial, Development, 108, 47, 10.1242/dev.108.1.47 · DOI

Sorted by citations

Items 101–200 of 1,014

Bone Morphogenetic ProteinsPreprint
Katagiri, T., & Watabe, T. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021899 · Cited by 561
Regulation of Osteoblast Differentiation by Runx2
Komori, T. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1050-9_5 · Cited by 530
Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation
An, J., Yang, H., Zhang, Q., Liu, C., Zhao, J., Zhang, L., & Chen, B. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.01.024 · Cited by 536
BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation
Matsubara, T., Kida, K., Yamaguchi, A., Hata, K., Ichida, F., Meguro, H., Aburatani, H., Nishimura, R., & Yoneda, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801774200 · Cited by 528
Tumor Necrosis Factor-α Promotes In Vitro Calcification of Vascular Cells via the cAMP Pathway
Tintut, Y., Patel, J., Parhami, F., & Demer, L. L. (2000) · Circulation · doi:10.1161/01.cir.102.21.2636 · Cited by 528
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient micePreprint
Takeda, S., Bonnamy, J.-P., Owen, M. J., Ducy, P. F., & Karsenty, G. (2001) · Genes & Development · doi:10.1101/gad.845101 · Cited by 518
Self-citation
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation
Lin, G. L., & Hankenson, K. D. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23287 · Cited by 525
Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development
Ge, C., Xiao, G., Jiang, D., & Franceschi, R. T. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610046 · Cited by 510
Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534
Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis
Takada, I., Kouzmenko, A., & Kato, S. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.137 · Cited by 511
Bone remodelling at a glance
Crockett, J. C., Rogers, M. J., Coxon, F. P., Hocking, L. J., & Helfrich, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.063032 · Cited by 532
Pathophysiology of Vascular Calcification in Chronic Kidney Disease
Moe, S. M., & Chen, N. X. (2004) · Circulation Research · doi:10.1161/01.res.0000141775.67189.98 · Cited by 502
Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
Birmingham, E., Niebur, G. L., McHugh, P. E., Shaw, G., Fp, B., & McNamara, L. M. (2012) · European Cells and Materials · doi:10.22203/ecm.v023a02 · Cited by 492
NFAT and Osterix cooperatively regulate bone formation
Koga, T., Matsui, Y., Asagiri, M., Kodama, T., Crombrugghe, B. D., Nakashima, K., & Takayanagi, H. (2005) · Nature Medicine · doi:10.1038/nm1270 · Cited by 497
Bone Sialoprotein
Ganss, B., Kim, R. H., & Sodek, J. (1999) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411990100010401 · Cited by 490
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
Zhu, S., Chen, W., Masson, A., & Li, Y. (2024) · Cell Discovery · doi:10.1038/s41421-024-00689-6 · Cited by 538
Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
Oury, F., Khrimian, L., Denny, C. A., Gardin, A., Chamouni, A., Goeden, N., Huang, Y.-Y., Lee, H., Srinivas, P., Gao, X.-B., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.042 · Cited by 484
Self-citation
Transcriptional control of chondrocyte fate and differentiation
Lefebvre, V., & Smits, P. J. (2005) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20048 · Cited by 477
The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem
Corre, I., Verrecchia, F., Crenn, V., Rédiní, F., & Trichet, V. (2020) · Cells · doi:10.3390/cells9040976 · Cited by 494
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.Preprint
Liu, Z.-H., Xu, J.-S., Colvin, J. S., & Ornitz, D. (2002) · Genes & Development · doi:10.1101/gad.965602 · Cited by 501
Dual roles of Wnt signaling during chondrogenesis in the chicken limb
Hartmann, C., & Tabin, C. J. (2000) · Development · doi:10.1242/dev.127.14.3141 · Cited by 472
Networks and hubs for the transcriptional control of osteoblastogenesis
Lian, J. B., Stein, G. S., Javed, A., van Wijnen, A. J., Stein, J. L., Montecino, M. A., Hassan, M. Q., Gaur, T., Lengner, C. J., & Young, D. W. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9001-5 · Cited by 473
Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2.
Lecka‐Czernik, B., Gubrij, I. B., Moerman, E. J., Kajkenova, O., Lipschitz, D. A., Manolagas, S. C., & Jilka, R. L. (1999) · PubMed · Cited by 464
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
Fujita, T., Azuma, Y., Fukuyama, R., Hattori, Y., Yoshida, C. A., Koida, M., Ogita, K., & Komori, T. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401138 · Cited by 462
Regulatory mechanisms in the pathways of cartilage and bone formation
Crombrugghe, B. D., Lefèbvre, V., & Nakashima, K. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00276-3 · Cited by 461
Silk implants for the healing of critical size bone defects
Meinel, L., Fajardo, R., Hofmann, S., Langer, R., Chen, J., Snyder, B. D., Vunjak‐Novakovic, G., & Kaplan, D. L. (2005) · Bone · doi:10.1016/j.bone.2005.06.010 · Cited by 460
Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program
Muruganandan, S., Roman, A. A., & Sinal, C. J. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8429-z · Cited by 470
Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
Maes, C., Carmeliet, P., Moermans, K., Stockmans, I., Smets, N., Collen, D., Bouillon, R., & Carmeliet, G. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00601-3 · Cited by 451
Bone Morphogenetic Proteins, Extracellular Matrix, and Mitogen-Activated Protein Kinase Signaling Pathways Are Required for Osteoblast-Specific Gene Expression and Differentiation in MC3T3-E1 Cells
Xiao, G., Gopalakrishnan, R., Jiang, D., Reith, E., Benson, M. D., & Franceschi, R. T. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.101 · Cited by 457
Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation
Wei, J., Shimazu, J., Makinistoglu, M. P., Maurizi, A., Kajimura, D., Zong, H., Takarada, T., Iezaki, T., Pessin, J. E., Hinoi, E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.029 · Cited by 469
Self-citation
Cbfa1 Isoforms Exert Functional Differences in Osteoblast Differentiation
Harada, H., Tagashira, S., Fujiwara, M., Ogawa, S., Katsumata, T., Yamaguchi, A., Komori, T., & Nakatsuka, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.6972 · Cited by 451
The runx genes: gain or loss of function in cancer
Blyth, K., Cameron, E. R., & Neil, J. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1607 · Cited by 461
Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms
Qin, Q., Xu, Y., He, T., Qin, C., & Xu, J. (2011) · Cell Research · doi:10.1038/cr.2011.144 · Cited by 465
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
Liu, W., Toyosawa, S., Furuichi, T., Kanatani, N., Yoshida, C. A., Liu, Y., Himeno, M., Narai, S., Yamaguchi, A., & Komori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105052 · Cited by 454
Regulation of chondrocyte differentiation by Cbfa1
Kim, I. S., Otto, F., Zabel, B., & Mundlos, S. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00210-x · Cited by 453
Interaction and Functional Cooperation of PEBP2/CBF with Smads
Hanai, J.-I., Chen, L. F., Kanno, T., Ohtani‐Fujita, N., Kim, W. Y., Guo, W.-H., Imamura, T., Ishidou, Y., Fukuchi, M., Shi, M.-J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31577 · Cited by 449
Matricellular Proteins in Cardiac Adaptation and Disease
Frangogiannis, N. G. (2012) · Physiological Reviews · doi:10.1152/physrev.00008.2011 · Cited by 459
Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis
Gofflot, F., Gaoua, W., Bourguignon, L., Roux, C., & Picard, J. J. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 27
Self-citation
Expression of the Osteoblast Differentiation Factor RUNX2 (Cbfa1/AML3/Pebp2αA) Is Inhibited by Tumor Necrosis Factor-α
Gilbert, L. C., He, X., FARMER, P. K., Rubin, J. E., Drissi, H., van Wijnen, A. J., Lian, J. B., Stein, G. S., & Nanes, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106339200 · Cited by 444
Advances in the osteoblast lineage
Aubin, J. E. (1998) · Biochemistry and Cell Biology · doi:10.1139/bcb-76-6-899 · Cited by 444
Divergent Effects of Selective Peroxisome Proliferator-Activated Receptor- 2 Ligands on Adipocyte Versus Osteoblast Differentiation
Lecka‐Czernik, B., Moerman, E. J., Grant, D. F., Lehmann, J. M., Manolagas, S. C., & Jilka, R. L. (2002) · Endocrinology · doi:10.1210/endo.143.6.8834 · Cited by 449
Tumor necrosis factor-α: molecular and cellular mechanisms in skeletal pathology
Nanes, M. S. (2003) · Gene · doi:10.1016/s0378-1119(03)00841-2 · Cited by 440
Osteomimetic properties of prostate cancer cells: A hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment
Koeneman, K. S., Yeung, F., & Chung, L. W. K. (1999) · The Prostate · doi:10.1002/(sici)1097-0045(19990601)39:4 · Cited by 442
The human adipose tissue is a source of multipotent stem cells
Rodriguez, A., Elabd, C., Amri, E., Ailhaud, G. P., & Dani, C. (2004) · Biochimie · doi:10.1016/j.biochi.2004.11.007 · Cited by 449
Transcriptional mechanisms in osteoblast differentiation and bone formation
Nakashima, K., & Crombrugghe, B. D. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00176-8 · Cited by 433
Bone physiology as inspiration for tissue regenerative therapies
Lopes, D., Martins‐Cruz, C., Oliveira, M. B., & Mano, J. F. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.028 · Cited by 458
The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal developmentPreprint
Robledo, R. F., Rajan, L., Li, X., & Lufkin, T. (2002) · Genes & Development · doi:10.1101/gad.988402 · Cited by 420
Osteoblast and osteocyte: Games without frontiers
Capulli, M., Paone, R., & Rucci, N. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.003 · Cited by 413
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
Greenblatt, M. B., Shim, J., Zou, W., Sitara, D., Schweitzer, M. N., Hu, D. Z., Lotinun, S., Sano, Y., Baron, R., Park, J. M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42285 · Cited by 414
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study
Zeggini, E. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60681-3 · Cited by 416
Cleidocranial dysplasia: clinical and molecular genetics
Mundlos, S. (1999) · Journal of Medical Genetics · doi:10.1136/jmg.36.3.177 · Cited by 407
BMP-2-induced Runx2 Expression Is Mediated by Dlx5, and TGF-β1 Opposes the BMP-2-induced Osteoblast Differentiation by Suppression of Dlx5 Expression
Lee, M., Kim, Y. J., Kim, H., Park, H.-D., Kang, A. H., Kyung, H., Sung, J.-H., Wozney, J. M., Kim, H., & Ryoo, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211386200 · Cited by 409
Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels
Das, R. K., Gocheva, V., Hammink, R., Zouani, O. F., & Rowan, A. E. (2015) · Nature Materials · doi:10.1038/nmat4483 · Cited by 407
Involvement of p38 mitogen-activated protein kinase in basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts
Kozawa, O., Tokuda, H., Matsuno, H., & Uematsu, T. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990901)74:3 · Cited by 48
“Mesenchymal” Stem Cells
Bianco, P. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013132 · Cited by 414
Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes
Dy, P., Wang, W., Bhattaram, P., Wang, Q., Wang, L., Ballock, R. T., & Lefebvre, V. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.024 · Cited by 389
Wnt5aandWnt5bexhibit distinct activities in coordinating chondrocyte proliferation and differentiation
Yang, Y., Topol, L. Z., Lee, H., & Wu, J. (2003) · Development · doi:10.1242/dev.00324 · Cited by 398
Mechanically induced osteogenic differentiation – the role of RhoA, ROCKII and cytoskeletal dynamics
Arnsdorf, E. J., Tummala, P., Kwon, R. Y., & Jacobs, C. R. (2009) · Journal of Cell Science · doi:10.1242/jcs.036293 · Cited by 401
BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2
Lee, M., Kwon, T., Park, H., Wozney, J. M., & Ryoo, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.058 · Cited by 394
Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation*
Turner, C. H., & Pavalko, F. M. (1998) · Journal of Orthopaedic Science · doi:10.1007/s007760050064 · Cited by 394
The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3
Pike, J. W., & Meyer, M. B. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.02.007 · Cited by 395
Fibrodysplasia ossificans progressiva
Kaplan, F. S., Merrer, M. F. L., Glaser, D. L., Pignolo, R. J., Goldsby, R. E., Kitterman, J. A., Groppe, J. C., & Shore, E. M. (2008) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2007.11.007 · Cited by 394
Transcriptional Control of Skeletogenesis
Karsenty, G. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164437 · Cited by 390
Self-citation
BMP Signaling Is Required for RUNX2-Dependent Induction of the Osteoblast Phenotype
Phimphilai, M., Zhao, Z., Boules, H., Roca, H., & Franceschi, R. T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060109 · Cited by 389
Activated parathyroid hormone/parathyroid hormone–related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone
Calvi, L. M., Sims, N. A., Hunzelman, J. L., Knight, M. C., Giovannetti, A., Saxton, J. M., Kronenberg, H. M., Baron, R., & Schipani, E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11296 · Cited by 388
Transcription factors controlling osteoblastogenesis
Marie, P. J. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.030 · Cited by 387
New Developments in the Pathogenesis and Treatment of Steroid-Induced Osteoporosis
Manolagas, S. C., & Weinstein, R. S. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1061 · Cited by 382
Cbfa1 Is a Positive Regulatory Factor in Chondrocyte Maturation
Enomoto, H., Enomoto‐Iwamoto, M., Iwamoto, M., Nomura, S., Himeno, M., Kitamura, Y., Kishimoto, T., & Komori, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8695 · Cited by 387
Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages
Chen, D., Ji, X., Harris, M. A., Feng, J. Q., Karsenty, G., Celeste, A. J., Rosen, V., Mundy, G. R., & Harris, S. E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.295 · Cited by 382
Self-citation
Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells
Ryoo, H., Lee, M., & Kim, Y. J. (2005) · Gene · doi:10.1016/j.gene.2005.10.011 · Cited by 379
Fibroblast Growth Factor 2 Induction of the Osteocalcin Gene Requires MAPK Activity and Phosphorylation of the Osteoblast Transcription Factor, Cbfa1/Runx2
Xiao, G., Jiang, D., Gopalakrishnan, R., & Franceschi, R. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206057200 · Cited by 378
Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds
Mygind, T., Stiehler, M., Baatrup, A., Li, H., Zou, X., Flyvbjerg, A., Kassem, M. S., & Bünger, C. E. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.10.003 · Cited by 378
Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis
Shi, S., Robey, P. G., & Gronthos, S. (2001) · Bone · doi:10.1016/s8756-3282(01)00612-3 · Cited by 378
Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts
Bellido, T., Ali, A., Plotkin, L. I., Fu, Q., Gubrij, I. B., Roberson, P. K., Weinstein, R. S., O’Brien, C. A., Manolagas, S. C., & Jilka, R. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307444200 · Cited by 377
Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor
Xiao, G., Wang, D., Benson, M. D., Karsenty, G., & Franceschi, R. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32988 · Cited by 379
Self-citation
Transcriptional Regulatory Cascades in Runx2-Dependent Bone Development
Liu, T. M., & Lee, E. H. (2012) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2012.0527 · Cited by 377
Molecular mechanisms of endochondral bone development
Provot, S., & Schipani, E. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.068 · Cited by 374
Real‐time quantitative RT‐PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro
Frank, O., Heim, M., Jakob, M., Barbero, A., Schäfer, D., Bendik, I., Dick, W., Heberer, M., & Martín, I. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10174 · Cited by 370
Dominance of SOX9 function over RUNX2 during skeletogenesis
Zhou, G. D., Zheng, Q., Engin, F., Munivez, E. M., Chen, Y., Sebald, E. T., Krakow, D., & Lee, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605170103 · Cited by 367
Skeletal Malformations Caused by Overexpression of Cbfa1 or Its Dominant Negative Form in Chondrocytes
Ueta, C., Iwamoto, M., Kanatani, N., Yoshida, C. A., Liu, Y., Enomoto‐Iwamoto, M., Ohmori, T., Enomoto, H., Nakata, K., Takada, K., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.1.87 · Cited by 367
The Retinoblastoma Protein Acts as a Transcriptional Coactivator Required for Osteogenic Differentiation
Thomas, D. M., Carty, S. A., Piscopo, D. M., Lee, J.-S., Wang, W.-F., Forrester, W. C., & Hinds, P. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00327-6 · Cited by 361
Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals
Akintoye, S. O., Lam, T., Shi, S., Brahim, J. S., Collins, M. T., & Robey, P. G. (2006) · Bone · doi:10.1016/j.bone.2005.10.027 · Cited by 357
Osteosarcoma Development and Stem Cell Differentiation
Tang, N., Song, W., Luo, J., Haydon, R. C., & He, T. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0335-z · Cited by 365
Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix
Gronthos, S., Simmons, P. J., Graves, S. E., & Robey, P. G. (2001) · Bone · doi:10.1016/s8756-3282(00)00424-5 · Cited by 355
C ellular , M olecular, and G enetic D eterminants of T ooth E ruption
Wise, G. E., Frazier‐Bowers, S. A., & D’Souza, R. N. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300403 · Cited by 351
Cbfa1 Contributes to the Osteoblast-specific Expression of type I collagen Genes
Kern, B., Shen, J. J., Starbuck, M. W., & Karsenty, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006215200 · Cited by 353
Self-citation
3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells
Wang, W., Itaka, K., Ohba, S., Nishiyama, N., Chung, U., Yamasaki, Y., & Kataoka, K. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.030 · Cited by 349
Diabetes Interferes with the Bone Formation by Affecting the Expression of Transcription Factors that Regulate Osteoblast Differentiation
Lü, H., Kraut, D., Gerstenfeld, L. C., & Graves, D. T. (2002) · Endocrinology · doi:10.1210/en.2002-220072 · Cited by 350
In vitro differentiation of embryonic stem cells into mineralized osteoblasts
Nieden, N. I. Z., Kempka, G., & Ahr, H. J. (2003) · Differentiation · doi:10.1046/j.1432-0436.2003.700602.x · Cited by 347
Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein
Lee, K., Hong, S.-H., & Bae, S. (2002) · Oncogene · doi:10.1038/sj.onc.1205937 · Cited by 353
Smooth Muscle Cell–Specific Runx2 Deficiency Inhibits Vascular Calcification
Sun, Y., Byon, C. H., Yuan, K., Chen, J., Mao, X., Heath, J. M., Javed, A., Zhang, K., Anderson, P. G., & Chen, Y. (2012) · Circulation Research · doi:10.1161/circresaha.112.267237 · Cited by 344
Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation
Jeon, E.-J., Lee, K.-Y., Choi, N.-S., Lee, M., Kim, H.-N., Jin, Y.-H., Ryoo, H., Choi, J., Yoshida, M., Nishino, N., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512494200 · Cited by 343
Paget disease of bone.
Roodman, G. D., & Windle, J. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24281 · Cited by 340
Parathyroid hormone-dependent signaling pathways regulating genes in bone cells
Swarthout, J. T., DʼAlonzo, R. C., Selvamurugan, N., & Partridge, N. C. (2002) · Gene · doi:10.1016/s0378-1119(01)00798-3 · Cited by 334
Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2
Zelzer, E., Glotzer, D. J., Hartmann, C., Thomas, D., Fukai, N., Söker, S., & Olsen, B. R. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00428-2 · Cited by 344
Endogenous TGF‐β signaling suppresses maturation of osteoblastic mesenchymal cells
Maeda, S., Hayashi, M., Komiya, S., Imamura, T., & Miyazono, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600067 · Cited by 340
Mesenchymal stem cells: characteristics and clinical applications.
Bobis‐Wozowicz, S., Jarocha, D. J., & Majka, M. (2006) · PubMed · doi:10.5603/4554 · Cited by 337
Atorvastatin Inhibits Hypercholesterolemia-Induced Cellular Proliferation and Bone Matrix Production in the Rabbit Aortic Valve
Rajamannan, N. M., Subramaniam, M., Springett, M. J., Sebo, T., Niekrasz, M., McConnell, J. P., Singh, R. J., Stone, N. J., Bonow, R. O., & Spelsberg, T. C. (2002) · Circulation · doi:10.1161/01.cir.0000017435.87463.72 · Cited by 335
Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells
Chen, N. X., O’Neill, K. D., Duan, D., & Moe, S. M. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00625.x · Cited by 334
Osteoinduction
Miron, R. J., & Zhang, Y. F. (2012) · Journal of Dental Research · doi:10.1177/0022034511435260 · Cited by 346

Authors: Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Karsenty, Gérard
ORCID: Ducy, Patricia
Zhang, Rui
Geoffroy, Valérie
Karsenty, Gérard
Venue: Cell
Publisher: Elsevier BV
Published: 1997-05
Volume: 89
Issue: 5
Pages: 747-754
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)80257-3
OpenAlex: W1994596418
Cited by: 4,246
References: 43
Citations by year: 2026: 40 · 2025: 46 · 2024: 59 · 2023: 83 · 2022: 93 · 2021: 106 · 2020: 137 · 2019: 148 · 2018: 123 · 2017: 176 · 2016: 153 · 2015: 175 · 2014: 184 · 2013: 198 · 2012: 198
FWCI: 34.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5921 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Dental and Craniofacial Research (DE11290, R01DE011290)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: osteogenic differentiation, transcription factors, osteocalcin promoter, osteoblast-specific gene expression, BMP-7, vitamin D3, mesenchymal condensation, skeletal development, osteoblast lineage
MeSH terms: Amino Acid Sequence, Animals, Cell Differentiation, Cloning, Molecular, Molecular Sequence Data, Neoplasm Proteins, Osteoblasts, Promoter Regions, Genetic, Transcription Factors, Trans-Activators, Osteocalcin, Cell Adhesion Molecules, DNA, Complementary, Gene Expression Regulation, Developmental, Core Binding Factor Alpha 1 Subunit, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks