Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the Biogenesis of Functional Mitochondria in Saccharomyces cerevisiae
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Fzo1p is a novel component required for the biogenesis of functional mitochondria in the yeast Saccharomyces cerevisiae. The protein is homologous to Drosophila Fzo, the first known protein mediator of mitochondrial fusion. Deletion of the FZO1 gene results in a petite phenotype, loss of mitochondrial DNA, and a fragmented mitochondrial morphology. Fzo1p is an integral protein of the mitochondrial outer membrane exposing its major part to the cytosol. It is imported into the outer membrane in a receptor-dependent manner. Fzo1p is part of a larger protein complex of 800 kDa, and presumably is the first identified component of the yeast mitochondrial fusion machinery.
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Mfn2 is a nuclear-encoded mitochondrial protein that is highly expressed in skeletal muscle, heart, and brain.
“Mfn2 is a nuclear-encoded mitochondrial protein that shows homology with Drosophila or yeast Fzo proteins (26,27) and is highly expressed in skeletal muscle, the heart, and the brain (23).”
From Expression of <i>Mfn2</i>, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle (2005) · cites this paper as [27]
The paper’s introduction says that proteins similar to Drosophila Fzo exist in mammals and yeast, supporting the homology context for citation (26,27), but it does not identify Mfn2 specifically. It does not establish that Mfn2 is nuclear-encoded or highly expressed in skeletal muscle, heart, and brain; the citing sentence attaches a different citation, (23), to the expression claim. (LLM, conf=0.82)
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- Authors
- Rapaport, D., Brunner, M., Neupert, W., & Westermann, B.
- Affiliations
- Adolf-Butenandt-Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie (DE)
- Corresponding author
- Neupert, Walter
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 273
- Issue
- 32
- Pages
- 20150-20155
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1980103053
- Cited by
- 370
- References
- 37
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 16 · 2019: 14 · 2018: 6 · 2017: 11 · 2016: 14 · 2015: 15 · 2014: 12 · 2013: 11 · 2012: 21
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ERef Bayreuth (University of Bayreuth) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- mitochondrial outer membrane, mitochondrial biogenesis, mitochondrial fusion, mitochondrial DNA loss, mitochondrial morphology, protein import, Saccharomyces cerevisiae
- MeSH terms
- Fungal Proteins, Genes, Fungal, Membrane Proteins, Mitochondria, Phenotype, Saccharomyces cerevisiae, Gene Deletion, GTP Phosphohydrolases, Mitochondrial Proteins, Saccharomyces cerevisiae Proteins
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