Cited by 879Circadian rhythm and melatoninLight effects on plantsSleep and Work-Related Fatigue

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A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

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Albrecht, Urs, Sun, Zhong Sheng, Eichele, Gregor, Lee, Cheng Chi·1997·Cell

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Abstract

A mouse gene, mper1, having all the properties expected of a circadian clock gene, was reported recently. This gene is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN). mper1 maintains this pattern of circadian expression in constant darkness and can be entrained to a new light/dark cycle. Here we report the isolation of a second mammalian gene, mper2, which also has these properties and greater homology to Drosophila period. Expression of mper1 and mper2 is overlapping but asynchronous by 4 hr. mper1, unlike period and mper2, is expressed rapidly after exposure to light at CT22. It appears that mper1 is the pacemaker component which responds to light and thus mediates photic entrainment.

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Authors: Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Lee, Cheng Chi
ORCID: Albrecht, Urs
Sun, Zhong Sheng
Lee, Cheng Chi
Venue: Cell
Publisher: Elsevier BV
Published: 1997-12
Volume: 91
Issue: 7
Pages: 1055-1064
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)80495-x
OpenAlex: W2151468131
Cited by: 879
References: 46
Citations by year: 2026: 6 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 16 · 2021: 27 · 2020: 17 · 2019: 20 · 2018: 16 · 2017: 27 · 2016: 27 · 2015: 22 · 2014: 29 · 2013: 28 · 2012: 26
FWCI: 15.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5707 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: mPer1, mPer2, clock genes, light entrainment, suprachiasmatic nucleus, light response, circadian pacemaker
MeSH terms: Amino Acid Sequence, Animals, Circadian Rhythm, Light, Male, Mice, Inbred C57BL, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Gene Expression, DNA, Complementary, Cell Cycle Proteins, Mice, Period Circadian Proteins

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A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

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