Cited by 76Circadian rhythm and melatoninSleep and related disordersSubstance Abuse Treatment and Outcomes

The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents

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Comasco, Erika, Nordquist, Niklas, Göktürk, Camilla, Åslund, Cecilia, Hallman, Jarmila, Oreland, Lars, Nilsson, Kent W.·2010·Upsala Journal of Medical Sciences

Abstract

BACKGROUND: Alcohol abuse is associated with sleep problems, which are often linked to circadian rhythm disturbances. Previous studies have separately examined the effects of mutations in the clock gene PER2 on alcohol consumption and sleep problems. Here we hypothesized that an allelic variation in the PER2 gene is associated with alcohol consumption in interaction with sleep problems among adolescents. METHODS: The Survey of Adolescent Life and Health in Västmanland 2006, a Swedish county, including 1254 students 17-18 years old, was used as a population-representative sample of adolescents. We investigated the PER2 Single Nucleotide polymorphism (SNP) 10870 (A/G) in the cohort together with an assessment of alcohol consumption according to the AUDIT-C questionnaire, and sleep problems using a survey consisting of 18 items. Furthermore, we carried out an exploratory analysis on the PER2 Single Nucleotide Polymorphism 10870 polymorphism in a group of severely alcoholic females. RESULTS: We found a significant association of the SNP 10870 in adolescent boys, where the genotype AA, in the presence of several and frequent sleep problems, was associated with increased alcohol consumption. Among adolescent girls, only sleep problems were related to alcohol consumption. A non-significant trend was observed among the severely alcoholic females, with the G allele being over-represented in the severely alcoholic females group in comparision to the control females. CONCLUSION: These results indicate that PER2 gene variation is associated with alcohol consumption in interaction with sleep problems among Swedish adolescent boys.

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  • Variants of PER2 are associated with D2 receptor availability and cocaine addiction vulnerability, risky alcohol drinking under high psychosocial stress, and disrupted sleep.

    “Variants of PER2 are associated with D2 receptor availability and cocaine addiction vulnerability (133,134); risky alcohol drinking under high psychosocial stress (135); and disrupted sleep (136).”

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Authors
Comasco, E., Nordquist, N., Göktürk, C., Åslund, C., Hallman, J., Oreland, L., & Nilsson, K. W.
Affiliations
  • Uppsala University (SE)
  • Uppsala University Hospital (SE)
Corresponding author
Comasco, Erika
Venue
Upsala Journal of Medical Sciences
Published
2010-02
Volume
115
Issue
1
Pages
41-48
ISSN
  • 0300-9734 (ISSN-L)
  • 2000-1967
OpenAlex
W2077245409
Cited by
76
References
42
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 6 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 4
FWCI
1.73
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Upsala Journal of Medical Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Regionala Forskningsrådet Uppsala/Örebro
  • Fredrik och Ingrid Thurings Stiftelse
  • Landstinget Västmanland
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
clock genes, sleep disorders, alcohol consumption, adolescents, single nucleotide polymorphisms, circadian rhythm, gene-environment interaction, sex differences
MeSH terms
Adolescent, Alcohol Drinking, Alcoholism, Female, Gene Expression Regulation, Gene Frequency, Genotype, Humans, Male, Sex Factors, Sleep Wake Disorders, Sweden, Cohort Studies, Polymorphism, Single Nucleotide, Period Circadian Proteins

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