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Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
Open accessAbstract
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.
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“Recent data suggest that the lateral hypothalamic area contains hyporcretin/orexin (de Lecea et al., 1998, Sakurai et al., 1998) neurons (Peyron et al., 1998), which appear to play a critical role in arousal (Siegel, 2004; Saper et al., 2005) and probably reward (Harris et al., 2005; Harris and Aston-Jones, 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Sakurai et al., 1998
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Metadata
- Authors
- Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W.-S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J., & Yanagisawa, M.
- Affiliations
- Howard Hughes Medical Institute (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Yanagisawa, Masashi
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 92
- Issue
- 4
- Pages
- 573-585
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2027740042
- Cited by
- 5,501
- References
- 57
- Citations by year
- 2026: 93 · 2025: 158 · 2024: 169 · 2023: 186 · 2022: 207 · 2021: 197 · 2020: 189 · 2019: 191 · 2018: 239 · 2017: 211 · 2016: 211 · 2015: 239 · 2014: 274 · 2013: 252 · 2012: 242
- FWCI
- 54.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- orexin-A, orexin B, orexin receptors, G protein-coupled receptors, hypothalamus, feeding behavior, energy homeostasis, neuropeptides, fasting, dietary intake, central regulation of feeding
- MeSH terms
- Orexins, Animals, Carrier Proteins, Chromatography, High Pressure Liquid, Fasting, Feeding Behavior, Cricetinae, Humans, Hypothalamus, Kidney, Male, Molecular Sequence Data, Neurons, Neuropeptides, Protein Precursors, Rabbits, RNA, Messenger, CHO Cells, Rats, Wistar, Sequence Homology, Amino Acid, Receptors, Neuropeptide, GTP-Binding Proteins, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins, Rats, Orexin Receptors
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