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A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts
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“…promotes formation of an immunological synapse that consists of a central cluster of T-cell receptors surrounded by a ring of adhesion molecules that sequesters kinases required for T-cell activation from across the inner cell membrane (Dustin et al., 1998; Monks et al., 1998; Wang et al., 2004).”
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“CD2AP encodes an adaptor protein that contains three SH3 motifs, a proline-rich region, and an actin binding domain (Dustin et al., 1998).”
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Metadata
- Authors
- Dustin, M. L., Olszowy, M. W., Holdorf, A. D., Li, J., Bromley, S., Desai, N., Widder, P., Rosenberger, F., van der Merwe, P. A., Allen, P. M., & Shaw, A. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 94
- Issue
- 5
- Pages
- 667-677
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2019286212
- Cited by
- 723
- References
- 2
- FWCI
- 17.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
