Cited by 189Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Abnormal Hippocampal Spatial Representations in αCaMKII T286A and CREB αΔ− Mice

Cho, Yoon H., Giese, Karl P., Tanila, Heikki, Silva, Alcino J., Eichenbaum, Howard·1998·Science

Abstract

Hippocampal "place cells" fire selectively when an animal is in a specific location. The fine-tuning and stability of place cell firing was compared in two types of mutant mice with different long-term potentiation (LTP) and place learning impairments. Place cells from both mutants showed decreased spatial selectivity. Place cell stability was also deficient in both mutants and, consistent with the severities in their LTP and spatial learning deficits, was more affected in mice with a point mutation [threonine (T) at position 286 mutated to alanine (A)] in the alpha calmodulin kinase II (alphaCaMKIIT286A) than in mice deficient for the alpha and Delta isoforms of adenosine 3'5'-monophosphate-responsive element binding proteins (CREBalphaDelta-). Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning.

Integrity signals

Registry

Crossref · 10.1126/science.279.5352.867

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Studies in knockin mice containing the T286A mutation of CaMKII show the importance of CaMKII in spatial selectivity.

    “Furthermore, studies in knockin mice containing the T286A mutation of CaMKII show the importance of CaMKII in spatial selectivity (421, 422).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [422]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cho, Y. H., Giese, K. P., Tanila, H., Silva, A. J., & Eichenbaum, H.
Affiliations
Boston University (US)
Corresponding author
Eichenbaum, Howard
Venue
Science
Published
1998-02-06
Volume
279
Issue
5352
Pages
867-869
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1992949123
Cited by
189
References
16
Citations by year
2026: 1 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 3 · 2019: 1 · 2018: 9 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 7
FWCI
10.46
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • National Institute on Aging (AG 13622)
  • National Institute of Mental Health (MH51570, R01MH051570)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
place cells, hippocampus, CaMKIIα, long-term potentiation, spatial learning, spatial selectivity, mouse mutants, synaptic plasticity
MeSH terms
Animals, Cues, Hippocampus, Learning, Mice, Inbred C57BL, Mice, Mutant Strains, Orientation, Space Perception, Point Mutation, Cyclic AMP Response Element-Binding Protein, Long-Term Potentiation, Calcium-Calmodulin-Dependent Protein Kinases, Pyramidal Cells, Maze Learning, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review