Direct recordings of grid-like neuronal activity in human spatial navigation
Open accessAbstract
Grid cells in the entorhinal cortex appear to represent spatial location via a triangular coordinate system. Such cells, which have been identified in rats, bats and monkeys, are believed to support a wide range of spatial behaviors. Recording neuronal activity from neurosurgical patients performing a virtual-navigation task, we identified cells exhibiting grid-like spiking patterns in the human brain, suggesting that humans and simpler animals rely on homologous spatial-coding schemes.
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Recent work has observed similar spatial codes in these regions in humans.
“recent work has observed similar spatial codes in these regions in humans4–8”
From Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe (2014) · cites this paper as [8]
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- Authors
- Jacobs, J., Weidemann, C. T., Miller, J. F., Solway, A., Burke, J. F., Wei, X.-X., Suthana, N., Sperling, M. R., Sharan, A. D., Fried, I., & Kahana, M. J.
- Affiliations
- Drexel University (US)
- Swansea University (GB)
- Princeton University (US)
- University of Pennsylvania (US)
- University of California, Los Angeles (US)
- Thomas Jefferson University (US)
- Corresponding author
- Jacobs, Joshua
- Fried, Itzhak
- Kahana, Michael J
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2013-08-04
- Volume
- 16
- Issue
- 9
- Pages
- 1188-1190
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3767317
- OpenAlex
- W2109417956
- Cited by
- 564
- References
- 23
- Citations by year
- 2026: 31 · 2025: 57 · 2024: 56 · 2023: 45 · 2022: 39 · 2021: 44 · 2020: 49 · 2019: 44 · 2018: 51 · 2017: 37 · 2016: 39 · 2015: 36 · 2014: 27 · 2013: 9
- FWCI
- 19.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- CogPrints (University of Southampton) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (MH061975, R01MH061975)
- National Institute of Neurological Disorders and Stroke (NS033221, R56NS033221, R01NS033221, R01NS084017)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- grid cells, entorhinal cortex, spatial coding, hippocampus, neurosurgical patients
- MeSH terms
- Action Potentials, Brain Mapping, Epilepsy, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Models, Neurological, Movement, Neurons, Space Perception, Spatial Behavior, Tomography, X-Ray Computed, User-Computer Interface, Entorhinal Cortex
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