Cited by 564Memory and Neural MechanismsSpatial Cognition and NavigationNeurogenesis and neuroplasticity mechanisms

Direct recordings of grid-like neuronal activity in human spatial navigation

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Jacobs, Joshua, Weidemann, Christoph T, Miller, Jonathan F, Solway, Alec, Burke, John F, Wei, Xue-Xin, Suthana, Nanthia, Sperling, Michael R +3 more·2013·Nature Neuroscience

Abstract

Grid cells in the entorhinal cortex appear to represent spatial location via a triangular coordinate system. Such cells, which have been identified in rats, bats and monkeys, are believed to support a wide range of spatial behaviors. Recording neuronal activity from neurosurgical patients performing a virtual-navigation task, we identified cells exhibiting grid-like spiking patterns in the human brain, suggesting that humans and simpler animals rely on homologous spatial-coding schemes.

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Research works printed but not linked: 2

  1. [1]O’Keefe J Dostrovsky J Brain Research 34 171 175 1971 5124915
  2. [15]Jacobs J Proceedings of the National Academy of Sciences, USA 107 6487 6482 2010

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Authors
Jacobs, J., Weidemann, C. T., Miller, J. F., Solway, A., Burke, J. F., Wei, X.-X., Suthana, N., Sperling, M. R., Sharan, A. D., Fried, I., & Kahana, M. J.
Affiliations
  • Drexel University (US)
  • Swansea University (GB)
  • Princeton University (US)
  • University of Pennsylvania (US)
  • University of California, Los Angeles (US)
  • Thomas Jefferson University (US)
Corresponding author
  • Jacobs, Joshua
  • Fried, Itzhak
  • Kahana, Michael J
Venue
Nature Neuroscience
Published
2013-08-04
Volume
16
Issue
9
Pages
1188-1190
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2109417956
Cited by
564
References
23
Citations by year
2026: 31 · 2025: 57 · 2024: 56 · 2023: 45 · 2022: 39 · 2021: 44 · 2020: 49 · 2019: 44 · 2018: 51 · 2017: 37 · 2016: 39 · 2015: 36 · 2014: 27 · 2013: 9
FWCI
19.93
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • CogPrints (University of Southampton) (acceptedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute of Mental Health (MH061975, R01MH061975)
  • National Institute of Neurological Disorders and Stroke (NS033221, R56NS033221, R01NS033221, R01NS084017)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
grid cells, entorhinal cortex, spatial coding, hippocampus, neurosurgical patients
MeSH terms
Action Potentials, Brain Mapping, Epilepsy, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Models, Neurological, Movement, Neurons, Space Perception, Spatial Behavior, Tomography, X-Ray Computed, User-Computer Interface, Entorhinal Cortex

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