Cited by 1,713BRCA gene mutations in cancerDNA Repair MechanismsPARP inhibition in cancer therapy

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Cancer Susceptibility and the Functions of BRCA1 and BRCA2

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Venkitaraman, Ashok R.·2002·Cell

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Abstract

Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers. Their ubiquitously expressed protein products are implicated in processes fundamental to all cells, including DNA repair and recombination, checkpoint control of cell cycle, and transcription. Here, I examine what is known about the biological functions of the BRCA proteins and ask how their disruption can induce susceptibility to specific types of cancer.

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Greenblatt, 2001, TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations, Cancer Res., 61, 4092

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Authors: Venkitaraman, A. R.
Affiliations: University of Cambridge (GB)
Corresponding author: Venkitaraman, Ashok R.
ORCID: Venkitaraman, Ashok R.
Venue: Cell
Publisher: Elsevier BV
Published: 2002-01
Volume: 108
Issue: 2
Pages: 171-182
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(02)00615-3
OpenAlex: W2066969492
Cited by: 1,713
References: 80
Citations by year: 2026: 28 · 2025: 39 · 2024: 49 · 2023: 60 · 2022: 52 · 2021: 60 · 2020: 53 · 2019: 43 · 2018: 55 · 2017: 50 · 2016: 66 · 2015: 63 · 2014: 69 · 2013: 68 · 2012: 65
FWCI: 14.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4215 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, BRCA2, hereditary cancer predisposition, breast cancer, ovarian cancer, DNA repair, DNA recombination, cell cycle checkpoint control, transcription, tumor suppressor proteins
MeSH terms: Animals, Breast Neoplasms, Cell Cycle, Cell Transformation, Neoplastic, Chromosome Fragility, DNA Damage, DNA Repair, DNA-Binding Proteins, Female, Humans, Models, Biological, Mutation, Neoplasms, Ovarian Neoplasms, BRCA1 Protein, Genes, BRCA1, Genetic Predisposition to Disease, Genes, BRCA2, BRCA2 Protein, Rad51 Recombinase

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Cancer Susceptibility and the Functions of BRCA1 and BRCA2

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