The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
Open accessAbstract
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers. Their ubiquitously expressed protein products are implicated in processes fundamental to all cells, including DNA repair and recombination, checkpoint control of cell cycle, and transcription. Here, I examine what is known about the biological functions of the BRCA proteins and ask how their disruption can induce susceptibility to specific types of cancer.
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“The key to targeted therapy, however, is that BRCA1 and BRCA2 have common functions in DNA double-strand break repair in the subpathway of homologous recombination [2,3].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [3]
In the citing paper
“BRCA2 mutation carriers, on the contrary, present tumours with pathologic features similar to those of sporadic tumours [2-10].”
From Is the breast-conserving treatment with radiotherapy appropriate in BRCA1/2 mutation carriers? Long-term results and review of the literature (2010) · cites this paper as [10]
In the citing paper
“Several studies suggest that BRCA gene mutation might influence response to radiation therapy because tumours in BRCA1/BRCA2 carriers are more sensitive to ionising radiation [5-12].”
From Is the breast-conserving treatment with radiotherapy appropriate in BRCA1/2 mutation carriers? Long-term results and review of the literature (2010) · cites this paper as [10]
Citations
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Metadata
- Authors
- Venkitaraman, A. R.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Venkitaraman, Ashok R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 108
- Issue
- 2
- Pages
- 171-182
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2066969492
- Cited by
- 1,713
- References
- 80
- Citations by year
- 2026: 28 · 2025: 39 · 2024: 49 · 2023: 60 · 2022: 52 · 2021: 60 · 2020: 53 · 2019: 43 · 2018: 55 · 2017: 50 · 2016: 66 · 2015: 63 · 2014: 69 · 2013: 68 · 2012: 65
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA1, BRCA2, hereditary cancer predisposition, breast cancer, ovarian cancer, DNA repair, DNA recombination, cell cycle checkpoint control, transcription, tumor suppressor proteins
- MeSH terms
- Animals, Breast Neoplasms, Cell Cycle, Cell Transformation, Neoplastic, Chromosome Fragility, DNA Damage, DNA Repair, DNA-Binding Proteins, Female, Humans, Models, Biological, Mutation, Neoplasms, Ovarian Neoplasms, BRCA1 Protein, Genes, BRCA1, Genetic Predisposition to Disease, Genes, BRCA2, BRCA2 Protein, Rad51 Recombinase
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