Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

The Integrative Action of the Nervous System.

Sherrington, C. (1907) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-190734120-00021 · Cited by 4,136

The molecular biology of memory storage: a dialogue between genes and synapses

Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917

Phosphorylated CREB binds specifically to the nuclear protein CBP

Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052

CBP/p300 in cell growth, transformation, and development

Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778

Protein synthesis and memory: A review.

Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.518 · Cited by 1,505

The Integrative Action of the Nervous System.

Freeman, F. N., & SHERRINGTON, S. C. (1907) · The Journal of Philosophy Psychology and Scientific Methods · doi:10.2307/2010953 · Cited by 906

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769

Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

Martin, K. C., Casadio, A., Zhu, H., Yaping, E., Rose, J. C., Chen, M., Bailey, C. H., & Kandel, E. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80484-5 · Cited by 740

In Vivo Cross-Linking and Immunoprecipitation for Studying Dynamic Protein:DNA Associations in a Chromatin Environment

Kuo, M., & Allis, C. D. (1999) · Methods · doi:10.1006/meth.1999.0879 · Cited by 601

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572

Epigenetics and the Environmental Regulation of the Genome and Its Function

Meaney, M. J. (2012) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199755059.003.0006 · Cited by 16

Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons

Zhang, Y., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-94393-0 · Cited by 15

Histone Deacetylase Inhibitors and Psychiatric Disorders

Chakravarty, S., Bhat, U. A., Reddy, R. G., Gupta, P. K., & Kumar, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00025-5 · Cited by 17

Reciprocal Stimulation of Decay Between Serotonergic Facilitation and Depression of Synaptic Transmission

Lee, S. H. C., Taylor, K., & Krasne, F. B. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90267.2008 · Cited by 16

The Emerging Role of ATP-Dependent Chromatin Remodeling in Memory and Substance Use Disorders

López, A. J., Hecking, J. K., & White, A. O. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186816 · Cited by 16

Insect Basic Leucine Zipper Proteins and Their Role in Cyclic AMP-Dependent Regulation of Gene Expression

Poels, J., & Broeck, J. V. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)41005-5 · Cited by 16

AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia

Lee, Y.-S., Choi, S.-L., Jun, H., Yim, S.-J., Lee, J.-A., Kim, H. F., Lee, S.-H., Shim, J., Lee, K., Jang, D.-J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116224109 · Cited by 15

Epigenetic mechanisms and memory strength: A comparative study

Federman, N., Zalcman, G., de la Fuente, V., Fustiñana, M. S., & Romano, A. G. (2014) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2014.06.003 · Cited by 16

The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice

Brénachot, X., Rigault, C., Nédélec, E., Laderrière, A., Khanam, T., Gouazé, A., Chaudy, S., Lemoine, A., Datiche, F., Gascuel, J., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.006 · Cited by 15

α/β-tubulin are A kinase anchor proteins for type I PKA in neurons

Kurosu, T., Hernandez, A. I., Wolk, J., Liu, J., & Schwartz, J. H. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.019 · Cited by 15

Early-life blockade of NMDA receptors induces epigenetic abnormalities in the adult medial prefrontal cortex: possible involvement in memory impairment in trace fear conditioning

Latusz, J., & Maćkowiak, M. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05362-5 · Cited by 15

Effect of morphine exposure on novel object memory of the offspring: The role of histone H3 and ΔFosB

Sadat‐Shirazi, M., Asgari, P., Mahboubi, S., Zadeh‐Tehrani, S. N., Ashabi, G., Rohbani, K., Sabzevari, S., Soltani, H., Khalifeh, S., & Zarrindast, M. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.011 · Cited by 15

Rescue of Impaired Long-Term Facilitation at Sensorimotor Synapses of Aplysia following siRNA Knockdown of CREB1

Zhou, L., Zhang, Y., Liu, R.-Y., Smolen, P., Cleary, L. J., & Byrne, J. H. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3330-14.2015 · Cited by 14

Histone post-translational modification and heterochromatin alterations in neurodegeneration: revealing novel disease pathways and potential therapeutics

Fisher, R. M. A., & Torrente, M. P. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1456052 · Cited by 18

Biphasic Regulation of p38 MAPK by Serotonin Contributes to the Efficacy of Stimulus Protocols That Induce Long-Term Synaptic Facilitation

Zhang, Y., Smolen, P. D., Baxter, D. A., & Byrne, J. H. (2017) · eNeuro · doi:10.1523/eneuro.0373-16.2017 · Cited by 12

Histone deacetylase 5 represses the transcription of cyclin D3

Roy, S., Shor, A. C., Bagui, T. K., Seto, E., & Pledger, W. J. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21771 · Cited by 14

Neurogenetic and Neuroepigenetic Mechanisms in Cognitive Health and Disease

Coda, D. M., & Gräff, J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.589109 · Cited by 17

Effects of Morphine and Maternal Care on Behaviors and Protein Expression of Male Offspring

Akbarabadi, A., Sadat‐Shirazi, M., Kabbaj, M., Zadeh‐Tehrani, S. N., Khalifeh, S., Pirri, F., & Zarrindast, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.011 · Cited by 13

Epigenetic Code and Self-Identity

Calvanese, V., Lara, E., & Fraga, M. F. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-1680-7_14 · Cited by 13

The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity

Mirisis, A. A., Alexandrescu, A., Carew, T. J., & Kopec, A. M. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.3.356 · Cited by 12

Histone and DNA Modifications in Mental Retardation

Iwase, S., & Shi, Y. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_8 · Cited by 13

Decreased level of histone acetylation in the infralimbic prefrontal cortex following immediate extinction may result in deficit of extinction memory

Singh, S. P., Siddiqui, S. A., Tripathy, S., Kumar, S., Saha, S., Ugale, R. R., Modi, D. R., & Prakash, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.06.004 · Cited by 14

c-Abl regulates a synaptic plasticity-related transcriptional program involved in memory and learning

González-Martín, A., Moyano, T. C., Gutiérrez, D. A., Carvajal, F. J., Cerpa, W. F., Hanley, J. G., Gutiérrez, R. A., & Alvarez, A. R. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102122 · Cited by 12

Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation

Hu, J., & Schacher, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2034-15.2015 · Cited by 12

Class II HDACs and Neuronal Regeneration

Tang, B. L. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24802 · Cited by 13

An Aplysia Egr homolog is rapidly and persistently regulated by long-term sensitization training

Cyriac, A., Holmes, G., Lass, J., Belchenko, D. D., Calin-Jageman, R. J., & Calin‐Jageman, I. E. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.03.008 · Cited by 12

Neurotransmitters and Memory

Meneses, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408139-0.00002-x · Cited by 12

Expression Levels of the Tyrosine Hydroxylase Gene and Histone Modifications Around its Promoter in the Locus Coeruleus and Ventral Tegmental Area of Rats during Forced Abstinence from Morphine

Mashayekhi, F. J., Rasti, M., Khoshdel, Z., & Owji, A. A. (2018) · European Addiction Research · doi:10.1159/000495362 · Cited by 12

CREB-Dependent Transcription and Synaptic Plasticity

Barco, Á., Jančić, D., & Kandel, E. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-73609-9_7 · Cited by 12

Mecanismos epigenéticos en el desarrollo de la memoria y su implicación en algunas enfermedades neurológicas

Reynoso, M. A. R., Ochoa-Hernández, A. B., Juárez-Vázquez, C. I., & Barros‐Núñez, P. (2014) · Neurología · doi:10.1016/j.nrl.2014.02.004 · Cited by 12

Histone deacetylase inhibition induces odor preference memory extension and maintains enhanced AMPA receptor expression in the rat pup modelPreprint

Bhattacharya, S., Mukherjee, B., Doré, J. J. E., Yuan, Q., Harley, C. W., & McLean, J. H. (2017) · Learning & Memory · doi:10.1101/lm.045799.117 · Cited by 13

MK-801, a NMDA receptor antagonist, increases phosphorylation of histone H3 in the rat medial prefrontal cortex

Maćkowiak, M., Guzik, R., Dudys, D., Bator, E., & Wędzony, K. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71469-5 · Cited by 11

SMRT ‐mediated co‐shuttling enables export of class II a HDAC s independent of their CaM kinase phosphorylation sites

Soriano, F. X., Chawla, S., Skehel, P., & Hardingham, G. E. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12058 · Cited by 11

Sensitization and Habituation: Invertebrate

Fioravante, D., Antzoulatos, E. G., & Byrne, J. H. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00005-x · Cited by 11

Localization of molecular correlates of memory consolidation to buccal ganglia mechanoafferent neurons after learning that food is inedible in AplysiaPreprint

Levitan, D., Madar, R., Teplinsky, A., & Susswein, A. J. (2012) · Learning & Memory · doi:10.1101/lm.026393.112 · Cited by 11

Alteration of epigenetic program to recover memory and alleviate neurodegeneration: prospects of multi-target molecules

Pandian, G. N., Taylor, R. D., Syed, J., Saha, A., Chandran, A., Vaijayanthi, T., & Sugiyama, H. (2014) · Biomaterials Science · doi:10.1039/c4bm00068d · Cited by 10

Chromatin remodeling and neuronal function: exciting links

Santos, M., Coelho, P. A., & Maciel, P. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00227.x · Cited by 10

Design (Docking and QSAR Studies) and synthesis of histone deacetylase 2 (HDAC2) inhibitors series

Martínez-Pacheco, H., Espinosa‐Raya, J., Picazo, O., Roldán-Roldán, G., Viñas‐Bravo, O., & Ramírez‐Galicia, G. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-2051-2 · Cited by 10

Modulating Cognition-Linked Histone Acetyltransferases (HATs) as a Therapeutic Strategy for Neurodegenerative Diseases: Recent Advances and Future Trends

Mai, H. A., Thomas, C. M., Nge, G. G., & Elefant, F. (2025) · Cells · doi:10.3390/cells14120873 · Cited by 10

Molecular and functional characterization of an evolutionarily conserved CREB ‐binding protein in the Lymnaea CNS

Hatakeyama, D., Sunada, H., Totani, Y., Watanabe, T., Felletár, I., Fitchett, A., Eravci, M., Anagnostopoulou, A., Miki, R., Okada, A., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101225rr · Cited by 9

Epigenetic Mechanisms of Mental Retardation

Schaefer, A., Tarakhovsky, A., & Greengard, P. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_7 · Cited by 9

Histone Post-translational Modifications to Target Memory-related Diseases

Monti, B. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319280005 · Cited by 9

An Expanding Spectrum of Autism Models From Fixed Developmental Defects to Reversible Functional Impairments

Herbert, M. R., & Anderson, M. P. (2008) · Cited by 9

Epigenetic mechanisms in the development of memory and their involvement in certain neurological diseases

Reynoso, M. A. R., Ochoa-Hernández, A. B., Juárez-Vázquez, C. I., & Barros‐Núñez, P. (2016) · Neurología (English Edition) · doi:10.1016/j.nrleng.2014.02.011 · Cited by 9

Molecular Mechanisms of Learning and Memory**The authors declare no competing financial interests.

Puzzo, D., Fiorito, J., Purgatorio, R., Gulisano, W., Palmeri, A., Arancio, O., & Nicholls, R. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802851-3.00001-2 · Cited by 11

Role of modulatory mediator serotonin in induction of epigenetic processes during long-term memory formation in Helix

Grinkevich, L. N., & Vorobiova, O. V. (2014) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059714060094 · Cited by 8

Epigenetics and the Formation of Long-Term Memory

Grinkevich, L. N. (2014) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-014-9897-2 · Cited by 8

Performance in long‐term memory tasks is augmented by a phosphorylated growth factor receptor fragment

Dash, P. K., Mach, S. A., Moody, M. R., & Moore, A. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20174 · Cited by 8

Epigenetic Regulation in Psychiatric Disorders

Tsankova, N. M., Renthal, W. R., Kumar, A., & Nestler, E. J. (2010) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.8.3.foc435 · Cited by 9

Superior long-term synaptic memory induced by combining dual pharmacological activation of PKA and ERK with an enhanced training protocolPreprint

Liu, R., Neveu, C. L., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2017) · Learning & Memory · doi:10.1101/lm.044834.116 · Cited by 8

ASTROGLIA: Molecular Mechanisms, Functional Roles, and Neurophysiological Implications in the Central Nervous System

Ortega, A., Martínez-Nuncio, L. A., Taddei, E., Castañeda-Saucedo, E., Rubio, C., & Rubio‐Osornio, M. (2025) · Life · doi:10.3390/life15101505 · Cited by 11

Histone Modifications in the Nervous System and Neuropsychiatric Disorders

Bridi, M. S., & Abel, T. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00002-1 · Cited by 8

Epigenetics and its implications for oral health

Singh, A., Gill, G., & Jakhu, H. (2018) · Journal of Oral Biosciences · doi:10.1016/j.job.2018.02.001 · Cited by 7

Increased histone acetylation levels or a serotonin precursor reinstate the context memory impaired by the serotonin receptor blocker methiothepin

Zuzina, A. B., & Vinarskaya, A. K. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01303-6 · Cited by 7

Synaptic Plasticity

Heidelberger, R., Shouval, H. Z., Zucker, R. S., & Byrne, J. H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397179-1.00018-x · Cited by 8

Expression of the SOFaRP2 gene in the central nervous system of the adult cuttlefish Sepia officinalis

Zhang, Z., & Tublitz, N. J. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.01.003 · Cited by 7

G protein coupled-receptor signaling and reversible lysine acetylation

Spiegelberg, B. D. (2013) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2013.822889 · Cited by 7

p38 МАРK is Involved in Regulation of Epigenetic Mechanisms of Food Aversion Learning

Grinkevich, L. N. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3816-9 · Cited by 7

Enhancement of psychotherapy using epigenetic modulating drugs

Gavin, D. P., Chase, K. A., & Sharma, R. P. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.03.042 · Cited by 6

Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents

Yamashita, Y., Itoh, Y., Takada, Y., & Suzuki, T. (2024) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c23-00027 · Cited by 7

Neurobiological insights into twice-exceptionality: Circuits, cells, and molecules

Kelvington, B. A., Nickl‐Jockschat, T., & Abel, T. G. (2022) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2022.107684 · Cited by 10

Memory Impairment after Drug-Facilitated Crimes

Saussereau, É., Guerbet, M., Anger, J.-P., & Goullé, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416748-3.00005-0 · Cited by 6

A Comparative Analysis of the Molecular Mechanisms Contributing to Implicit and Explicit Memory Storage in Aplysia and in the Hippocampus ☆

Hawkins, R. D., Mayford, M. R., & Kandel, E. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21095-x · Cited by 6

Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of Aplysia californica

Harini, L., Coughlin, B. L., Darr, A. S., & Byrne, J. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-04634-4 · Cited by 6

An Expanding Spectrum of Autism Models

Herbert, M. R., & Anderson, M. P. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-489-0_20 · Cited by 6

Aberrant expression of long non-coding RNAs and their regulatory role in chromatin-mediated gene expression changes in the prefrontal cortex of major depressive disorder subjects

Dwivedi, Y., & Roy, B. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03396-0 · Cited by 7

Group housing enhances mating and increases the sensitization of chemical cues in Bactrocera dorsalis

Chen, Y., Zhang, Y., Yang, L., Chen, W., Jiang, Z., Xiao, Z., Xie, X., Zhong, G., & Yi, X. (2022) · Pest Management Science · doi:10.1002/ps.7208 · Cited by 5

Comparison between relative and absolute quantitative real-time PCR applied to single-cell analyses: Transcriptional levels in a key neuron for long-term memory in the pond snail

Hatakeyama, D., Chikamoto, N., Fujimoto, K., Kitahashi, T., & Ito, E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0279017 · Cited by 5

Direct and Inherited Epigenetic Changes in the Nervous System Caused by Intensive Locomotion: Possible Adaptive Significance

Mezheritskiy, M., & Dyakonova, V. E. (2022) · Russian Journal of Developmental Biology · doi:10.1134/s1062360422050058 · Cited by 5

On the origin and nature of nongenetic information in eumetazoans

Cabej, N. R. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15001 · Cited by 5

The Role of CREB in Neuronal Plasticity, Learning and Memory, and in Neuropsychiatric Disorders

(2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/978160805257811201010022 · Cited by 5

Dynamics and Mechanisms of ERK Activation after Different Protocols that Induce Long-Term Synaptic Facilitation in Aplysia

Zhang, Y., Liu, R., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2022) · Oxford Open Neuroscience · doi:10.1093/oons/kvac014 · Cited by 6

Suberoylanilide hydroxamic acid attenuates cognitive impairment in offspring caused by maternal surgery during mid-pregnancy

Feng, Y., Qin, J., Lu, Y., Wang, M., Wang, S., & Luo, F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0295096 · Cited by 5

The Epigenetics of Neural Learning

Bronfman, Z. Z., Ginsburg, S., & Jablonka, E. (2016) · Wiley eBooks · doi:10.1002/9781118650813.ch7 · Cited by 6

Studies of Histone H3 Methylation during the Formation of Long-Term Memory

Grinkevich, L. N. (2014) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-014-9953-y · Cited by 4

Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice

Upadhya, S. C., Smith, T. K., Brennan, P., Mychaleckyj, J. C., & Hegde, A. N. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.08.009 · Cited by 4

Through the Immune Looking Glass: A Model for Brain Memory Strategies

Sánchez‐Ramón, S., & Faure, F. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00017 · Cited by 4

DNA Methylation in Eukaryotes: Regulation and Function

Niller, H. H., Demcsák, A., & Minárovits, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-20796-4_24-1 · Cited by 4

Contribution of histone acetylation to the serotonin-mediated long-term synaptic plasticity in terrestrial snails

Zuzina, A. B., & Balaban, P. M. (2022) · Journal of Comparative Physiology A · doi:10.1007/s00359-022-01562-1 · Cited by 5

Enhancing Associative Learning in Rats With a Computationally Designed Training Protocol

Zhang, X. O., Zhang, Y., Cho, C. E., Engelke, D. S., Smolen, P. D., Byrne, J. H., & Monte, F. H. D. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.07.006 · Cited by 4

Memory-enhancing effects of short-term fasting

Totani, Y., 中井, 純., Hatakeyama, D., & Ito, E. (2020) · The European Zoological Journal · doi:10.1080/24750263.2020.1827053 · Cited by 4

Histone Deacetylase Inhibitor Prevents Memory Impairment by Methiothepin

Zuzina, A. B., Vinarskaya, A. K., Balaban, P. M., & Roshchin, M. V. (2021) · Advances in intelligent systems and computing · doi:10.1007/978-3-030-71637-0_71 · Cited by 4

Activity‐Dependent Regulation of Transcription During Development of Synapses

Sanyal, S., & Ramaswami, M. (2006) · International review of neurobiology · doi:10.1016/s0074-7742(06)75013-9 · Cited by 4

Opposing roles of serotonin and neuropeptide FMRFamide in the regulation of epigenetic processes involved in the long-term memory formation

Grinkevich, L. N., & Vorobiova, O. V. (2017) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059717030054 · Cited by 4

Postsynaptic effects of Aplysia cysteine-rich neurotrophic factor in the induction of activity-dependent long-term facilitation in Aplysia californicaPreprint

Alexandrescu, A., & Carew, T. J. (2020) · Learning & Memory · doi:10.1101/lm.051011.119 · Cited by 3

Early life exercise primes the neural epigenome to facilitate gene expression and hippocampal memory consolidationPreprint

Raus, A. M., Fuller, T. D., Nelson, N., Valientes, D. A., Bayat, A., & Ivy, A. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.23.473936 · Cited by 4

Learning and Memory in Invertebrates: C. Elegans

Timbers, T., & Rankin, C. H. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00798-1 · Cited by 4

The microbiota-gut-brain-epigenome axis as a novel therapeutic target for decoding postpartum depression

Zheng, B., Xiaoming, S. H. E. N., Han, N., Guo, X. D., & Wan, S. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1778348 · Cited by 4

Effects of β−hydroxy-β-methylbutyrate (HMB) supplementation on biomarkers for cognitive function and electrophysiological processes in aging

Belagodu, A. P., Kang, S., Gulley, J. M., & Galvez, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817990-1.00054-8 · Cited by 3

Histone acetylation increase rescues a weak remote fear memory in rats

Vinarskaya, A. K., Zuzina, A. B., & Balaban, P. M. (2023) · Genes and Cells · doi:10.17816/gc623277 · Cited by 3

Role of Epigenetics in the Brain

Matt, S. M., Roth, E. D., & Roth, T. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00005-x · Cited by 3

Synaptic Mechanisms of Induction and Maintenance of Long-Term Sensitization Memory in Aplysia

Glanzman, D. L. (2013) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-415823-8.00017-4 · Cited by 3

Epigenetics: Integrating Genetic Programs, Brain Development and Emergent Phenotypes

Weaver, I. C. G. (2014) · Cell & Developmental Biology · doi:10.4172/2168-9296.1000132 · Cited by 3

Specific Changes in c-fos Expression and Colocalization with DNA in Identified Neuronal Nuclei of Edible Snail Following Neurotransmitter Application

Shevelkin, A. V., Efimova, O., Nikitin, V. P., Anokhin, K. V., & Sherstnev, V. V. (2012) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-012-1813-6 · Cited by 3

Gene environment meshing: A primordial stepping towards behavioural modulation

Wani, A. L., & Ara, A. (2015) · Postępy Psychiatrii i Neurologii · doi:10.1016/j.pin.2015.02.004 · Cited by 3

Temporal lobe epilepsy: a unique window into living human brain epigenetic gene regulation

Grote, A., Schoch, S., & Becker, A. J. (2015) · Brain · doi:10.1093/brain/awu386 · Cited by 3

Epigenetics – Chromatin Structure and Rett Syndrome

Levenson, J. M., & Wood, M. A. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00043-7 · Cited by 3

Synaptic and Cellular Basis of Learning

Bailey, C. H., & Kandel, E. R. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb001028 · Cited by 3

Addictive drug abuse and depression-a focus on epigenetics

Zhang, W., Xu, M., Wang, C., Liang, H., Zhu, X., Pan, Y., & Guo, F. (2026) · Communications Biology · doi:10.1038/s42003-026-09705-9 · Cited by 2

The Cell Biology of Learning and Memory in Aplysia

Glanzman, D. L. (2008) · Advances in psychology · doi:10.1016/s0166-4115(08)10021-8 · Cited by 2

Long-term Depression Overcomes Long-term Facilitation

(2002) · Science Signaling · doi:10.1126/scisignal.1602002tw445

Serotonin-Mediated Synapsin Expression Is Necessary for Long-Term Facilitation of theAplysiaSensorimotor Synapse

Hart, A. K., Fioravante, D., Liu, R., Phares, G. A., Cleary, L. J., & Byrne, J. H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2816-11.2011 · Cited by 36

Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia

Liu, R.-Y., Shah, S., Cleary, L. J., & Byrne, J. H. (2011) · Learning & Memory · doi:10.1101/lm.2112111 · Cited by 24

The Requirement for Enhanced CREB1 Expression in Consolidation of Long-Term Synaptic Facilitation and Long-Term Excitability in Sensory Neurons of Aplysia

Liu, R.-Y., Cleary, L. J., & Byrne, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5071-10.2011 · Cited by 60

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572