Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia
Open accessAbstract
Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found that treatment with 5-HT and behavioral training produce biphasic changes in the expression of CREB2, a transcriptional repressor. An immediate increase in CREB2 protein was followed by a subsequent decrease. The effects of these treatments persist for at least 24 h and are observed in isolated sensory neurons. This study suggests that the dynamics of CREB2 expression could contribute to the consolidation of memory.
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In Aplysia californica sensory neurons, the level of the transcription repressor CREB2 shows a late drop at about 12 hours after treatment.
“In addition, in these sensory neurons, the level of the transcription repressor CREB2 shows a late drop at ~12 hours after treatment56.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [56]
Slow dynamics of additional biochemical cascades contribute to LTM, such as changes in the synthesis of transcription factors CREB1 and CREB2.
“For example, the slow dynamics of additional biochemical cascades contribute to LTM (e.g., changes in the synthesis of transcription factors such as CREB1 and CREB22,32).”
From Computational design of enhanced learning protocols (2012) · cites this paper as [32]
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- Authors
- Liu, R.-Y., Shah, S., Cleary, L. J., & Byrne, J. H.
- Affiliations
- The University of Texas at Austin (US)
- The University of Texas Health Science Center at Houston (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-03-25
- Volume
- 18
- Issue
- 4
- Pages
- 245-249
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC3072775
- OpenAlex
- W2105830774
- Cited by
- 24
- References
- 32
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NS019895)
- National Institute of Neurological Disorders and Stroke (NS019895, R01NS019895)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- ATF4, serotonin, behavioral training, long-term memory, Aplysia, sensory neurons, transcriptional repressor, memory consolidation, synaptic plasticity, gene expression dynamics
- MeSH terms
- Animals, Antibodies, Aplysia, Behavior, Animal, Cells, Cultured, Conditioning, Classical, Electric Stimulation, Gene Expression Regulation, Functional Laterality, Nerve Tissue Proteins, Sensory Receptor Cells, Repressor Proteins, RNA, Messenger, Serotonin, Time Factors, Cyclic AMP Response Element-Binding Protein, Nonlinear Dynamics, Ganglia, Invertebrate
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