The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal
Open accessAbstract
Efficient engulfment of the intact cell corpse is a critical end point of apoptosis, required to prevent secondary necrosis and inflammation. The presentation of "eat-me" signals on the dying cell is an important part of this process of recognition and engulfment by professional phagocytes. Here, we present evidence that apoptotic cells secrete chemotactic factor(s) that stimulate the attraction of monocytic cells and primary macrophages. The activation of caspase-3 in the apoptotic cell was found to be required for the release of this chemotactic factor(s). The putative chemoattractant was identified as the phospholipid, lysophosphatidylcholine. Further analysis showed that lysophosphatidylcholine was released from apoptotic cells due to the caspase-3 mediated activation of the calcium-independent phospholipase A(2). These data suggest that in addition to eat-me signals, apoptotic cells display attraction signals to ensure the efficient removal of apoptotic cells and prevent postapoptotic necrosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, autoimmunity has been observed in mice in which phagocytes lack the G-protein coupled receptor G2A41, which is required for the response to lysophosphatidylcholine 42”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [41]
Citations
Cites
3 retracted
Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A
Kabarowski, J. H. S., Zhu, K., Le, L. Q., Witte, O. N., & Xu, Y. (2001) · Science · doi:10.1126/science.1061781 · Cited by 332
Self-citationRetractedSphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
Xu, Y., Zhu, K., Hong, G., Wu, W., Baudhuin, L. M., Xiao, Y.-J., & Damron, D. S. (2000) · Nature Cell Biology · doi:10.1038/35010529 · Cited by 289
Self-citationRetractedZhu, K., Baudhuin, L. M., Hong, G., Williams, F. S., Cristina, K. L., Kabarowski, J. H. S., Witte, O. N., & Xu, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008057200 · Cited by 242
Self-citationRetractedFadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 1×
“Conversely, by the expression of anti-inflammatory cytokines such caspases might directly cleave the putative inhibitor and as transforming growth factor- (Fadok et al., 1998). thereby release iPLA2.”
BackgroundCaspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis
Jänicke, R. U., Sprengart, M. L., Wati, M. R., & Porter, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9357 · Cited by 1,955
Natural adjuvants: Endogenous activators of dendritic cells
Gallucci, S., Lolkema, M. P., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,601
Corpse clearance defines the meaning of cell death
Savill, J., & Fadok, V. A. (2000) · Nature · doi:10.1038/35037722 · Cited by 1,572
A receptor for phosphatidylserine-specific clearance of apoptotic cells
Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
Sebbagh, M., Renvoizé, C., Hamelin, J., Riché, N., Bertoglio, J., & Bréard, J. (2001) · Nature Cell Biology · doi:10.1038/35070019 · Cited by 915
Cited by
Sorted by citations
Items 201–300 of 965
Frasch, S. C., Henson, P. M., Nagaosa, K., Fessler, M. B., Borregaard, N., & Bratton, D. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313414200 · Cited by 113
Microparticles Release by Adipocytes Act as “Find-Me” Signals to Promote Macrophage Migration
Eguchi, A., Mulya, A., Lazić, M., Radhakrishnan, D., Berk, M. P., Povero, D., Górnicka, A., & Feldstein, A. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123110 · Cited by 116
Surface‐exposed calreticulin in the interaction between dying cells and phagocytes
Martins, I., Kepp, O., Galluzzi, L., Senovilla, L., Schlemmer, F., Adjemian, S., Menger, L., Michaud, M., Zitvogel, L., & Kroemer, G. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05740.x · Cited by 112
Li, F., Chong, Z. Z., & Maiese, K. (2004) · Neurosignals · doi:10.1159/000081963 · Cited by 113
Derer, A., Deloch, L., Rubner, Y., Fietkau, R., Frey, B., & Gaipl, U. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00505 · Cited by 113
Exosome release by reticulocytes—An integral part of the red blood cell differentiation system
Blanc, L., Gassart, A. D., Géminard, C., Bette‐Bobillo, P., & Vidal, M. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.008 · Cited by 111
The effect of ageing on the resolution of inflammation
Sendama, W. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.101000 · Cited by 111
Krispin, A., Bledi, Y., Atallah, M., Trahtemberg, U., Verbovetski, I., Nahari, E., Zelig, O., Michal Linial, B., & Mevorach, D. (2006) · Blood · doi:10.1182/blood-2006-03-013334 · Cited by 108
Glycobiology of cell death: when glycans and lectins govern cell fate
Lichtenstein, R. G., & Rabinovich, G. A. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.50 · Cited by 107
Gubern, A., Barceló-Torns, M., Casas, J., Barneda, D., Masgrau, R., Picatoste, F., Balsinde, J., Balboa, M. A., & Claro, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806173200 · Cited by 107
Crosstalk between macrophages and cardiac cells after myocardial infarction
Jian, Y., Zhou, X. J., Shan, W., Chen, C., Ge, W., Cui, J., Yi, W., & Sun, Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01105-4 · Cited by 114
Kim, S. Y., Jo, H., Kim, M. H., Cha, Y., Choi, S. W., Shim, J., Kim, T. J., & Lee, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806578200 · Cited by 104
Targeted bone remodeling involves BMU steering as well as activation
Martin, R. B. (2007) · Bone · doi:10.1016/j.bone.2007.02.023 · Cited by 103
The innate immune system and the clearance of apoptotic cells
Devitt, A., & Marshall, L. J. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211095 · Cited by 109
The role of nucleotides in the neuron–glia communication responsible for the brain functions
Inoue, K., Koizumi, S., & Tsuda, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04824.x · Cited by 105
Microenvironmental influences of apoptosis in vivo and in vitro
Gregory, C. D., & Pound, J. D. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0485-9 · Cited by 103
Yamaguchi, H., Maruyama, T., Urade, Y., & Nagata, S. (2014) · eLife · doi:10.7554/elife.02172 · Cited by 100
Harada, H., Kizaka‐Kondoh, S., & Hiraoka, M. (2005) · Molecular Imaging · doi:10.1162/15353500200505112 · Cited by 103
Regulation of efferocytosis as a novel cancer therapy
Zhou, Y., Yao, Y., Deng, Y., & Shao, A. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00542-9 · Cited by 100
The role of IgM antibodies in the recognition and clearance of apoptotic cells
Peng, Y., Kowalewski, R., Kim, S., & Elkon, K. B. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2004.07.045 · Cited by 100
Clearance of Dying Cells by Phagocytes: Mechanisms and Implications for Disease Pathogenesis
Fond, A. M., & Ravichandran, K. S. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-39406-0_2 · Cited by 97
Macrophage profiling in atherosclerosis: understanding the unstable plaque
Gianopoulos, I., & Daskalopoulou, S. S. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-023-01023-z · Cited by 101
Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2 (Lp-PLA2 ): a review
da Silva, I. T., de MELLO, A. P. D. F. A. C., & Damasceno, N. R. T. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-170 · Cited by 99
Regulation of immune responses by neutrophils
Wang, J., & Arase, H. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12445 · Cited by 106
New Insights into Microglia–Neuron Interactions: A Neuron’s Perspective
Pósfai, B., Cserép, C., Orsolits, B., & Dénes, Á. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.046 · Cited by 98
Olofsson, K. E., Andersson, L. I. M., Nilsson, J. Å., & Björkbacka, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.087 · Cited by 98
Astudillo, A. M., Balboa, M. A., & Balsinde, J. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101207 · Cited by 102
Savill, J., Gregory, C. D., & Haslett, C. (2003) · Science · doi:10.1126/science.1092533 · Cited by 97
The immune functions of phosphatidylserine in membranes of dying cells and microvesicles
Frey, B., & Gaipl, U. S. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0228-6 · Cited by 106
Pérez, R., Melero, R., Balboa, M. A., & Balsinde, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402562200 · Cited by 96
Calcium-independent phospholipase A2 and apoptosis
Balsinde, J., Pérez, R., & Balboa, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.07.013 · Cited by 96
Lysophosphatidylcholine Modulates Neutrophil Oxidant Production through Elevation of Cyclic AMP
Lin, P., Welch, E. J., Gao, X.-P., Malik, A. B., & Ye, R. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2981 · Cited by 96
New roles for old enzymes: killer caspases as the engine of cell behavior changes
Connolly, P. F., Jäger, R., & Fearnhead, H. O. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00149 · Cited by 96
Venegas, V., & Zhou, Z. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-02-0138 · Cited by 95
Peripheral blood mononuclear cell secretome for tissue repair
Beer, L., Mildner, M., Gyöngyösi, M., & Ankersmit, H. J. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1292-8 · Cited by 97
Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment
Pitt, J. M., Kroemer, G., & Zitvogel, L. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-67577-0_5 · Cited by 98
Frasch, S. C., Berry, K. A. Z., Murphy, R. C., Borregaard, N., Henson, P. M., & Bratton, D. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6540 · Cited by 94
Targeting Efferocytosis in Inflammaging
Poon, I. K. H., & Ravichandran, K. S. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-032723-110507 · Cited by 100
Cleavage of Annexin A1 by ADAM10 during Secondary Necrosis Generates a Monocytic “Find-Me” Signal
Blume, K., Soeroes, S., Keppeler, H., Stevanović, S., Kretschmer, D., Rautenberg, M., Wesselborg, S., & Lauber, K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004073 · Cited by 92
Self-citationFraser, D. D., Slessarev, M., Martin, C. M., Daley, M., Patel, M. A., Miller, M. R., Patterson, E. K., O’Gorman, D. B., Gill, S. E., Wishart, D. S., et al. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000272 · Cited by 114
When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death
Bock, F. J., & Riley, J. S. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01082-0 · Cited by 94
Role of pancreatic β ‐cell death and inflammation in diabetes
Quan, W., Jo, E., & Lee, M. ‐. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12153 · Cited by 92
Phagocytic astrocytes: Emerging from the shadows of microglia
Konishi, H., Koizumi, S., & Kiyama, H. (2022) · Glia · doi:10.1002/glia.24145 · Cited by 88
From cancer immunosurveillance to cancer immunotherapy
Stagg, J., Johnstone, R. W., & Smyth, M. J. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00566.x · Cited by 91
Clearance deficiency—A potential link between infections and autoimmunity
Schulze, C., Munoz, L. E., Franz, S., Sarter, K., Chaurio, R. A., Gaipl, U. S., & i, M. H. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.07.049 · Cited by 89
Xiao, L., Zhang, L., Guo, C., Xin, Q., Gu, X., Jiang, C., & Wu, J. (2024) · 癌症:英文版 · doi:10.1002/cac2.12579 · Cited by 87
Werthmöller, N., Frey, B., Wunderlich, R., Fietkau, R., & Gaipl, U. S. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.129 · Cited by 88
Fas and TRAIL ‘death receptors’ as initiators of inflammation: Implications for cancer
Cullen, S. P., & Martin, S. J. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.01.012 · Cited by 94
Senescence induction; a possible cancer therapy
LLeonart, M. E., Artero‐Castro, A., & Kondoh, H. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-3 · Cited by 90
Driscoll, W. S., Vaisar, T., Tang, J., Wilson, C. L., & Raines, E. W. (2013) · Circulation Research · doi:10.1161/circresaha.112.300683 · Cited by 87
Delineating the roles of neutrophils and macrophages in zebrafish regeneration models
Keightley, M.-C., Wang, C., Pazhakh, V., & Lieschke, G. J. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.07.010 · Cited by 82
Liu, L., Yin, T., Chen, Y., Li, Y., Yin, L., Ding, J., Yang, J., & Feng, H.-L. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.08.008 · Cited by 84
Anti-Inflammatory Neutrophil Functions in the Resolution of Inflammation and Tissue Repair
Loh, W., & Vermeren, S. (2022) · Cells · doi:10.3390/cells11244076 · Cited by 92
Chong, Z. Z., & Maiese, K. (2004) · PubMed · doi:10.14670/hh-19.495 · Cited by 84
Laplante, P., Sirois, I., Raymond, M.-A., Kokta, V., Béliveau, A., Prat, A., Pshezhetsky, A. V., & Hébert, M. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.124 · Cited by 87
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Soteriou, D., & Fuchs, Y. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.122 · Cited by 87
How to improve the immunogenicity of chemotherapy and radiotherapy
Ma, Y., Conforti, R., Aymeric, L., Locher, C., Kepp, O., Kroemer, G., & Zitvogel, L. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9283-2 · Cited by 88
Macrophages Discriminate Glycosylation Patterns of Apoptotic Cell-derived Microparticles
Bilyy, R. O., Shkandina, T., Tomin, A., Munoz, L. E., Franz, S., Antonyuk, V., Kit, Y. Y., Zirngibl, M., Fürnrohr, B. G., Janko, C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.273144 · Cited by 83
Self-citationJohann, A. M., von Knethen, A., Lindemann, D., & Brüne, B. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401832 · Cited by 85
Genetic deletion of CD36 enhances injury after acute neonatal stroke
Woo, M., Wang, X., Faustino, J. V., Derugin, N., Wendland, M. F., Zhou, P., Iadecola, C., & Vexler, Z. S. (2012) · Annals of Neurology · doi:10.1002/ana.23727 · Cited by 82
Ghesquiere, S. A. I., Gijbels, M. J., Anthonsen, M. W., van Gorp, P. J., van der Made, I., Johansen, B., Hofker, M. H., & de Winther, M. P. J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400253-jlr200 · Cited by 82
How Does Ionizing Irradiation Contribute to the Induction of Anti-Tumor Immunity?
Rubner, Y., Wunderlich, R., Rühle, P.-F., Kulzer, L., Werthmöller, N., Frey, B., Weiss, E., Keilholz, L., Fietkau, R., & Gaipl, U. S. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00075 · Cited by 84
Hong, J., Lin, G.-H., Lin, C. J., Wang, W.-P., Lee, C., Lin, T.-L., & Wu, J. (2004) · Development · doi:10.1242/dev.01409 · Cited by 81
The dendritic cell–tumor cross-talk in cancer
Ma, Y., Aymeric, L., Locher, C., Kroemer, G., & Zitvogel, L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.09.008 · Cited by 80
Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity
Zent, C. S., & Elliott, M. R. (2016) · FEBS Journal · doi:10.1111/febs.13961 · Cited by 81
Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication
Sirois, I., Raymond, M.-A., Brassard, N., Cailhier, J., Fedjaev, M., Hamelin, K., Londoño, I., Bendayan, M., Pshezhetsky, A. V., & Hébert, M. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.126 · Cited by 80
After cell death: the molecular machinery of efferocytosis
Moon, B., Yang, S., Moon, H., Lee, J., & Park, D. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01070-5 · Cited by 78
Schimek, V., Strasser, K., Beer, A., Göber, S., Walterskirchen, N., Brostjan, C., Müller, C., Bachleitner‐Hofmann, T., Bergmann, M. M., Dolznig, H., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04585-3 · Cited by 79
Rupp, J., Pfleiderer, L., Jugert, C., Möller, S., Klinger, M. H. F., Dalhoff, K., Solbach, W., Stenger, S., Laskay, T., & van Zandbergen, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006020 · Cited by 78
Caspase activation regulates the extracellular export of autophagic vacuoles
Sirois, I., Groleau, J., Pallet, N., Brassard, N., Hamelin, K., Londoño, I., Pshezhetsky, A. V., Bendayan, M., & Hébert, M. (2012) · Autophagy · doi:10.4161/auto.19768 · Cited by 81
Heo, D. K., Lim, H. M., Nam, J., Lee, M. G., & Kim, J. Y. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.11.003 · Cited by 84
Girkontaitė, I., Sakk, V., Wagner, M., Borggrefe, T., Tedford, K., Chun, J. J. M., & Fischer, K. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041483 · Cited by 79
Blume, K., Soeroes, S., Waibel, M., Keppeler, H., Wesselborg, S., i, M. H., Schulze‐Osthoff, K., & Lauber, K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902250 · Cited by 77
Self-citationModified Lipoproteins Induce Arterial Wall Inflammation During Atherogenesis
Lorey, M. B., Öörni, K., & Kovanen, P. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.841545 · Cited by 82
Endothelial Apoptosis and Chronic Transplant Vasculopathy: Recent Results, Novel Mechanisms
Cailhier, J., Laplante, P., & Hébert, M. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.01165.x · Cited by 77
Mechanisms of failed apoptotic cell clearance by phagocyte subsets in cardiovascular disease
Thorp, E. B. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0516-6 · Cited by 79
Pieragostino, D., D’Alessandro, M., di Ioia, M., Rossi, C., Zucchelli, M., Urbani, A., Ilio, C. D., Lugaresi, A., Sacchetta, P., & Boccio, P. D. (2015) · Molecular BioSystems · doi:10.1039/c4mb00700j · Cited by 76
Zhao, Z., Zhang, X. H., Zhao, C., Choi, J.-W., Shi, J., Song, K., TURK, J. W., & Ma, Z. A. (2010) · Endocrinology · doi:10.1210/en.2010-0016 · Cited by 78
O'Sullivan, M. P., O'Leary, S., Kelly, D. M., & Keane, J. (2007) · Infection and Immunity · doi:10.1128/iai.01107-06 · Cited by 74
Caspase-3 and prostaglandins signal for tumor regrowth in cancer therapy
Galluzzi, L., Kepp, O., & Kroemer, G. (2011) · Oncogene · doi:10.1038/onc.2011.459 · Cited by 75
Stock, C. M., Schilling, T., Schwab, A., & Eder, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8560 · Cited by 76
Fat Cell and Fatty Acid Turnover in Obesity
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_6 · Cited by 75
P2Y4 Receptor-Mediated Pinocytosis Contributes to Amyloid Beta-Induced Self-Uptake by Microglia
Li, H.-Q., Chen, C., Dou, Y., Wu, H.-J., Liu, Y.-J., Lou, H.-F., Zhang, J.-M., Li, X.-M., Wang, H., & Duan, S. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00544-13 · Cited by 73
The role of phospholipases A2 in schizophrenia
Law, M. H., Cotton, R. G. H., & Berger, G. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001819 · Cited by 73
From regulation of dying cell engulfment to development of anti-cancer therapy
Krysko, D. V., & Vandenabeele, P. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402271 · Cited by 71
López‐Vales, R., Navarro, X., Shimizu, T., Baskakis, C., Kokotos, G., Constantinou‐Kokotou, V., Stephens, D. L., Dennis, E. A., & David, S. (2008) · Brain · doi:10.1093/brain/awn188 · Cited by 71
MFG-E8 Released by Apoptotic Endothelial Cells Triggers Anti-Inflammatory Macrophage Reprogramming
Brissette, M.-J., Lepage, S. E., Lamonde, A.-S., Sirois, I., Groleau, J., Laurin, L., & Cailhier, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036368 · Cited by 70
Cell Labeling and Tracking Method without Distorted Signals by Phagocytosis of Macrophages
Kang, S., Lee, S., Na, J. H., Yoon, H. I., Lee, D., Koo, H., Cho, Y. W., Kim, S. H., Jeong, S. Y., Kwon, I. C., et al. (2014) · Theranostics · doi:10.7150/thno.7265 · Cited by 70
Murakami, M., Masuda, S., Ueda-Semmyo, K., Yoda, E., Kuwata, H., Takanezawa, Y., Aoki, J., Arai, H., Sumimoto, H., Ishikawa, Y., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413766200 · Cited by 70
Verhoeckx, K. C. M., Bijlsma, S., Jespersen, S., Ramaker, R., Verheij, E. R., Witkamp, R. F., van der Greef, J., & Rodenburg, R. J. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.07.008 · Cited by 70
Parks, B. W., Black, L. L., Zimmerman, K. A., Metz, A. E., Steele, C. H., Murphy-Ullrich, J. E., & Kabarowski, J. H. S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m035352 · Cited by 69
Apoptotic cells induce arginase II in macrophages, thereby attenuating NO production
Johann, A. M., Barra, V., Kühn, A., Weigert, A., von Knethen, A., & Brüne, B. (2007) · The FASEB Journal · doi:10.1096/fj.06-7815com · Cited by 68
Mesquita, R. D., Carneiro, A. B., Báfica, A. L. B., Gazos‐Lopes, F., Takiya, C. M., Souto-Padrón, T. C. B. S., Vieira, D. P., Ferreira‐Pereira, A., de Almeida, I. C., Figueiredo, R. T., et al. (2008) · Infection and Immunity · doi:10.1128/iai.00683-08 · Cited by 69
Apoptotic Cells at the Crossroads of Tolerance and Immunity
Škoberne, M., Beignon, A., Larsson, M., & Bhardwaj, N. (2005) · Springer eBooks · doi:10.1007/3-540-27320-4_12 · Cited by 69
Gil‐de‐Gómez, L., Astudillo, A. M., Guijas, C., Magrioti, V., Kokotos, G., Balboa, M. A., & Balsinde, J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302267 · Cited by 67
Fogarty, C. E., & Bergmann, A. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.07.013 · Cited by 66
Mitochondrial targeting as a novel therapy for stroke
Borlongan, C., Russo, E., Nguyen, H., Lippert, T., Tuazon, J. P., & Napoli, E. (2018) · Brain Circulation · doi:10.4103/bc.bc_14_18 · Cited by 67
Wedemeyer, I., Bechmann, L. P., Odenthal, M., Jochum, C., Marquitan, G., Drebber, U., Gerken, G., Gieseler, R. K. H., Dienes, H. P., & Canbay, A. E. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.08.023 · Cited by 66
Seifert, S., Pannell, M., Uckert, W., Färber, K., & Kettenmann, H. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.03.005 · Cited by 66
Xia, C., Campbell, K. A., & Clare-Salzler, M. J. (2009) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32832ce943 · Cited by 66
Metadata
- Authors
- Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., Xu, Y., Autenrieth, I. B., Schulze-Osthoff, K., Belka, C., Stuhler, G., & Wesselborg, S.
- Affiliations
- University of Tübingen (DE)
- Cleveland Clinic (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Wesselborg, Sebastian
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 113
- Issue
- 6
- Pages
- 717-730
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2159330173
- Cited by
- 967
- References
- 35
- Citations by year
- 2026: 31 · 2025: 31 · 2024: 42 · 2023: 41 · 2022: 50 · 2021: 40 · 2020: 32 · 2019: 31 · 2018: 43 · 2017: 33 · 2016: 37 · 2015: 39 · 2014: 44 · 2013: 43 · 2012: 36
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3699 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- efferocytosis, caspase-3, lysophosphatidylcholine, phagocyte migration, macrophages, monocytic cells, calcium-independent phospholipase A2, eat-me signals, secondary necrosis, inflammation
- MeSH terms
- Animals, Chemotaxis, Enzyme Inhibitors, Eukaryotic Cells, Humans, Inflammation, Lysophosphatidylcholines, Phagocytes, Phagocytosis, Phospholipases A, Protein Synthesis Inhibitors, Signal Transduction, Ankyrin Repeat, Apoptosis, HT29 Cells, COS Cells, Caspases, Cell Surface Extensions, Lipid Metabolism, Mice, Caspase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review