Regulation of efferocytosis as a novel cancer therapy

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,365 · see citing works

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321 · see citing works

Calreticulin exposure dictates the immunogenicity of cancer cell death

Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216 · see citing works

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · see citing works

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824 · see citing works

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Clynes, R. A., Towers, T. L., Presta, L. G., & Ravetch, J. V. (2000) · Nature Medicine · doi:10.1038/74704 · Cited by 2,768 · see citing works

Distinct role of macrophages in different tumor microenvironments

Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225 · see citing works

The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022 · see citing works

Immunosuppressive effects of apoptotic cells

Voll, R. E., Herrmann, M., Roth, E. A., Stach, C., Kalden, J. R., & Girkontaite, I. (1997) · Nature · doi:10.1038/37022 · Cited by 1,787 · see citing works

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.045 · Cited by 1,752 · see citing works

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P. D., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R. K., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,667 · see citing works

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473 · see citing works

Annexins: linking Ca2+ signalling to membrane dynamics

Gerke, V., Creutz, C. E., & Moss, S. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1661 · Cited by 1,412 · see citing works

Identification of a factor that links apoptotic cells to phagocytes

Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2002) · Nature · doi:10.1038/417182a · Cited by 1,401 · see citing works

Therapeutic antibodies: successes, limitations and hopes for the future

Chames, P., Van Regenmortel, M., Weiss, E., & Baty, D. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00190.x · Cited by 1,382 · see citing works

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.

Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333 · see citing works

Identification of Tim4 as a phosphatidylserine receptor

Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., & Nagata, S. (2007) · Nature · doi:10.1038/nature06307 · Cited by 1,180 · see citing works

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

Vergadi, E., Ieronymaki, E., Lyroni, K., Vaporidi, K., & Tsatsanis, C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601515 · Cited by 1,148 · see citing works

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

Chao, M. P., Alizadeh, A. A., Tang, C. Z., Myklebust, J. H., Varghese, B., Gill, S. I., Jan, M., Cha, A. C., Chan, C. K. F., Tan, B. T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.044 · Cited by 1,095 · see citing works

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-F., Goswami, S. K., Stanley, E. R., Segall, J. E., Pollard, J. W., & Condeelis, J. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1823 · Cited by 1,053 · see citing works

Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., & Nagata, S. (2004) · Science · doi:10.1126/science.1094359 · Cited by 992 · see citing works

Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00422-7 · Cited by 967 · see citing works

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

Staunton, D. E., Marlin, S. D., Stratowa, C., Dustin, M. L., & Springer, T. A. (1988) · Cell · doi:10.1016/0092-8674(88)90434-5 · Cited by 954 · see citing works

Integrin-associated protein (CD47) and its ligands

Brown, E. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01906-1 · Cited by 880 · see citing works

BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

Park, D., Tosello‐Trampont, A., Elliott, M. R., Lu, M., Haney, L. B., Ma, Z., Klibanov, A. L., Mandell, J. W., & Ravichandran, K. S. (2007) · Nature · doi:10.1038/nature06329 · Cited by 848 · see citing works

TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer

Linger, R. M. A., Keating, A. K., Earp, H. S., & Graham, D. K. (2008) · Advances in cancer research · doi:10.1016/s0065-230x(08)00002-x · Cited by 750 · see citing works

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

Birge, R. B., Boeltz, S., Kumar, S., Carlson, J., Wanderley, J. L. M., Calianese, D. C., Barcinski, M. A., Brekken, R. A., Huang, X., Hutchins, J., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.11 · Cited by 731 · see citing works

Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family

Lu, Q., & Lemke, G. (2001) · Science · doi:10.1126/science.1061663 · Cited by 699 · see citing works

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

Kobayashi, N., Karisola, P., Peña-Cruz, V., Dorfman, D., Jinushi, M., Umetsu, S., Butte, M., Nagumo, H., Chernova, I., Zhu, B., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.011 · Cited by 688 · see citing works

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

Kojima, Y., Volkmer, J.-P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., Direnzo, D., Nanda, V., Ye, J., Connolly, A. J., et al. (2016) · Nature · doi:10.1038/nature18935 · Cited by 683 · see citing works

Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades

Hubbard, A. K., & Rothlein, R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00223-9 · Cited by 594 · see citing works

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Ravichandran, K. S. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.004 · Cited by 559 · see citing works

Clearance of Apoptotic Cells

Lauber, K., Blumenthal, S. G., Waibel, M., & Wesselborg, S. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00237-0 · Cited by 552 · see citing works

Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer

Kurahara, H., Shinchi, H., Mataki, Y., Maemura, K., Noma, H., Kubo, F., Sakoda, M., Ueno, S., Natsugoe, S., & Takao, S. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.05.026 · Cited by 552 · see citing works

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

Ravichandran, K. S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 547 · see citing works

AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications

Zhu, C., Wei, Y., & Wei, X. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1090-3 · Cited by 498 · see citing works

Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL

Liu, L., Greger, J., Shi, H., Liu, Y., Greshock, J., Annan, R., Halsey, W., Sathe, G. M., Martin, A.-M., & Gilmer, T. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4490 · Cited by 495 · see citing works

Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

Myers, K. V., Amend, S. R., & Pienta, K. J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1022-2 · Cited by 482 · see citing works

Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

Obeid, M., Panaretakis, T., Joza, N., Tufi, R., Tesniere, A., van Endert, P., Zitvogel, L., & Kroemer, G. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402201 · Cited by 474 · see citing works

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Truman, L. A., Ford, C. A., Pasikowska, M., Pound, J. D., Wilkinson, S. J., Dumitriu, I. E., Melville, L., Melrose, L. A., Ogden, C. A., Nibbs, R., et al. (2008) · Blood · doi:10.1182/blood-2008-06-162404 · Cited by 473 · see citing works

Increased exposure of anionic phospholipids on the surface of tumor blood vessels.

Ran, S., Downes, A., & Thorpe, P. E. (2002) · PubMed · Cited by 471 · see citing works

Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor

Park, S.-Y., Jung, M.-Y., Kim, H.-J., Lee, S., Kim, S.-Y., Lee, B.-H., Kwon, T.-H., Park, R. W., & Kim, I. T. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402242 · Cited by 464 · see citing works

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Paolino, M., Choidas, A., Wallner, S., Pranjic, B., Uribesalgo, I., Loeser, S., Jamieson, A. M., Langdon, W. Y., Ikeda, F., Fededa, J. P., et al. (2014) · Nature · doi:10.1038/nature12998 · Cited by 456 · see citing works

Burying the Dead

Vandivier, R. W., Henson, P. M., & Douglas, I. S. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1673 · Cited by 450 · see citing works

Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

Brown, S., Heinisch, I., Ross, E., Shaw, K., Buckley, C. D., & Savill, J. (2002) · Nature · doi:10.1038/nature00811 · Cited by 390 · see citing works

αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

Albert, M. L., Kim, J.-I., & Birge, R. B. (2000) · Nature Cell Biology · doi:10.1038/35046549 · Cited by 377 · see citing works

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine‐1‐phosphate as a “come‐and‐get‐me” signal

Gude, D., Alvarez, S. E., Paugh, S. W., Mitra, P., Yu, J., Griffiths, R., Barbour, S. E., Milstien, S., & Spiegel, S. (2008) · The FASEB Journal · doi:10.1096/fj.08-107169 · Cited by 364 · see citing works

TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

van der Meer, J. H. M., van der Poll, T., & Veer, C. V. ′. (2014) · Blood · doi:10.1182/blood-2013-09-528752 · Cited by 341 · see citing works

A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.

Camenisch, T. D., Koller, B. H., Earp, H. S., & Matsushima, G. K. (1999) · PubMed · Cited by 321 · see citing works

A Novel Receptor Tyrosine Kinase, Mer, Inhibits TNF-α Production and Lipopolysaccharide-Induced Endotoxic Shock

Camenisch, T. D., Koller, B. H., Earp, H. S., & Matsushima, G. K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3498 · Cited by 290 · see citing works

The role of efferocytosis in atherosclerosis

Kojima, Y., Weissman, I. L., & Leeper, N. J. (2017) · Circulation · doi:10.1161/circulationaha.116.025684 · Cited by 289 · see citing works

The immune response to secondary necrotic cells

Sachet, M., Liang, Y. Y., & Oehler, R. (2017) · Apoptosis · doi:10.1007/s10495-017-1413-z · Cited by 282 · see citing works

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

Lew, E. D., Oh, J., Burrola, P., Lax, I., Zagórska, A., Través, P. G., Schlessinger, J., & Lemke, G. (2014) · eLife · doi:10.7554/elife.03385 · Cited by 271 · see citing works

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

Kim, D., Wang, J., Willingham, S. B., Martin, R. K., Wernig, G., & Weissman, I. L. (2012) · Leukemia · doi:10.1038/leu.2012.141 · Cited by 249 · see citing works

Macrophages as mediators of tumor immunosurveillance

Jaiswal, S., Chao, M. P., Majeti, R., & Weissman, I. L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.04.001 · Cited by 241 · see citing works

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

He, M. T., Kubo, H., Morimoto, K., Fujino, N., Suzuki, T., Takahasi, T., Yamada, M., Yamaya, M., Maekawa, T., Yamamoto, Y., et al. (2011) · EMBO Reports · doi:10.1038/embor.2011.28 · Cited by 232 · see citing works

Cancer Neoantigens and Applications for Immunotherapy

Desrichard, A., Snyder, A., & Chan, T. A.-T. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3175 · Cited by 217 · see citing works

Differences between the clearance of apoptotic cells by professional and non-professional phagocytes

Parnaik, R., RAFF, M. C., & Scholes, J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00598-4 · Cited by 216 · see citing works

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

Ramirez‐Ortiz, Z. G., Pendergraft, W. F., Prasad, A., Byrne, M. H., Iram, T., Blanchette, C. J., Luster, A. D., Hacohen, N., Khoury, J. B. E., & Means, T. K. (2013) · Nature Immunology · doi:10.1038/ni.2670 · Cited by 214 · see citing works

Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor

Sainaghi, P. P., Castello, L. M., Bergamasco, L., Galletti, M., Bellosta, P., & Avanzi, G. C. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20265 · Cited by 209 · see citing works

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

Chao, M. P., Tang, C. Z., Pachynski, R. K., Chin, R., Majeti, R., & Weissman, I. L. (2011) · Blood · doi:10.1182/blood-2011-02-338020 · Cited by 196 · see citing works

MFG-E8–mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF

Jinushi, M., Nakazaki, Y., Dougan, M. L., Carrasco, D. R., Mihm, M. C., & Dranoff, G. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30966 · Cited by 195 · see citing works

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

Cook, R. S., Jacobsen, K. M., Wofford, A., DeRyckere, D., Stanford, J. C., Prieto, A. L., Redente, E. F., Sandahl, M. A., Hunter, D. M., Strunk, K. E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67655 · Cited by 186 · see citing works

Polarization of Prostate Cancer-associated Macrophages Is Induced by Milk Fat Globule-EGF Factor 8 (MFG-E8)-mediated Efferocytosis

Soki, F. N., Koh, A. J., Jones, J., Kim, Y. W., Dai, J., Keller, E. T., Pienta, K. J., Atabai, K., Roca, H., & McCauley, L. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.571620 · Cited by 173 · see citing works

Opportunities and challenges in the development of kinase inhibitor therapy for cancerPreprint

Sawyers, C. L. (2003) · Genes & Development · doi:10.1101/gad.1152403 · Cited by 170 · see citing works

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

Loges, S., Schmidt, T., Tjwa, M., Geyte, K. V., Lievens, D., Lutgens, E., Vanhoutte, D., Borgel, D., Plaisance, S., Hoylaerts, M., et al. (2009) · Blood · doi:10.1182/blood-2009-06-228684 · Cited by 163 · see citing works

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

Miller, M. A., Oudin, M. J., Sullivan, R. J., Wang, S. J., Meyer, A. S., Im, H., Frederick, D. T., Tadros, J., Griffith, L. G., Lee, H., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0933 · Cited by 163 · see citing works

Spontaneous tumor rejection by cbl-b –deficient CD8+ T cells

Loeser, S., Loser, K., Bijker, M. S., Rangachari, M., van der Burg, S. H., Wada, T., Beissert, S., Melief, C. J. M., & Penninger, J. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061699 · Cited by 161 · see citing works

Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland1

Monks, J., Smith-Steinhart, C., Kruk, E. R., Fadok, V. A., & Henson, P. M. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.065045 · Cited by 158 · see citing works

Tim4- and MerTK-Mediated Engulfment of Apoptotic Cells by Mouse Resident Peritoneal Macrophages

Nishi, C., Toda, S., Segawa, K., & Nagata, S. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01394-13 · Cited by 157 · see citing works

Autophosphorylation Docking Site Tyr-867 in Mer Receptor Tyrosine Kinase Allows for Dissociation of Multiple Signaling Pathways for Phagocytosis of Apoptotic Cells and Down-modulation of Lipopolysaccharide-inducible NF-κB Transcriptional Activation

Tibrewal, N., Wu, Y., D’Mello, V., Akakura, R., George, T. C., Varnum, B. C., & Birge, R. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706906200 · Cited by 156 · see citing works

TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy

Akalu, Y. T., Rothlin, C. V., & Ghosh, S. (2017) · Immunological Reviews · doi:10.1111/imr.12522 · Cited by 156 · see citing works

Efferocytosis in the tumor microenvironment

Werfel, T. A., & Cook, R. S. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0698-5 · Cited by 156 · see citing works

Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib

Giles, K. M., Kalinowski, F. C., Candy, P. A., Epis, M. R., Zhang, P. M., Redfern, A. D., Stuart, L. M., Goodall, G. J., & Leedman, P. J. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0170 · Cited by 155 · see citing works

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

Bosurgi, L., Bernink, J. H., Cuevas, V. D., Gagliani, N., Joannas, L. D., Schmid, E. T., Booth, C. J., Ghosh, S., & Rothlin, C. V. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302507110 · Cited by 151 · see citing works

Phosphatidylserine-Targeting Antibody Induces M1 Macrophage Polarization and Promotes Myeloid-Derived Suppressor Cell Differentiation

Yin, Y., Huang, X., Lynn, K. D., & Thorpe, P. E. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0073 · Cited by 149 · see citing works

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

Goyette, M.-A., Duhamel, S., Aubert, L., Pelletier, A., Savage, P., Thibault, M.-P., Johnson, R. M., Carmeliet, P., Basik, M., Gaboury, L. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.019 · Cited by 144 · see citing works

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

Kariolis, M. S., Miao, Y. R., Jones, D. S., Kapur, S., Mathews, I. I., Giaccia, A. J., & Cochran, J. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1636 · Cited by 143 · see citing works

Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis

Weinger, J. G., Brosnan, C. F., Loudig, O., Goldberg, M. F., Macian, F., Arnett, H. A., Prieto, A. L., Tsiperson, V., & Shafit-Zagardo, B. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-49 · Cited by 134 · see citing works

Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer

Sen, T., Tong, P., Diao, L., Li, L., Fan, Y.-H., Hoff, J. A., Heymach, J. V., Wang, J., & Byers, L. A. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1284 · Cited by 134 · see citing works

A Monoclonal Antibody that Binds Anionic Phospholipids on Tumor Blood Vessels Enhances the Antitumor Effect of Docetaxel on Human Breast Tumors in Mice

Huang, X., Bennett, M. A., & Thorpe, P. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0031 · Cited by 133 · see citing works

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

Baghdadi, M., Yoneda, A., Yamashina, T., Nagao, H., Komohara, Y., Nagai, S., Akiba, H., Foretz, M., Yoshiyama, H., Kinoshita, I., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.014 · Cited by 130 · see citing works

Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression

Kasikara, C., Kumar, S., Kimani, S. G., Tsou, W., Geng, K., Davra, V., Sriram, G., Devoe, C., Nguyen, K.-Q. N., Lewis-Antes, A., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0350 · Cited by 129 · see citing works

HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrin

Friggeri, A., Yang, Y., Banerjee, S., Park, Y.-J., Liu, G., & Abraham, E. H. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00152.2010 · Cited by 128 · see citing works

ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis

Yang, M. H., Liu, J., Piao, C., Shao, J., & Du, J. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.144 · Cited by 127 · see citing works

The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

Flannagan, R. S., Canton, J., Furuya, W., Glogauer, M., & Grinstein, S. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-04-0212 · Cited by 126 · see citing works

Milk Fat Globule EGF-8 Promotes Melanoma Progression through Coordinated Akt and Twist Signaling in the Tumor Microenvironment

Jinushi, M., Nakazaki, Y., Carrasco, D. R., Draganov, D., Souders, N. C., Johnson, M., Mihm, M. C., & Dranoff, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2147 · Cited by 125 · see citing works

Ablation of Cbl-b provides protection against transplanted and spontaneous tumors

Chiang, J. Y., Jang, I. K., Hodes, R., & Gu, H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29472 · Cited by 124 · see citing works

Resistance to CD4+CD25+ Regulatory T Cells and TGF-β in Cbl-b−/− Mice

Wohlfert, E. A., Callahan, M. K., & Clark, R. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1059 · Cited by 121 · see citing works

Immune Responses in Bladder Cancer-Role of Immune Cell Populations, Prognostic Factors and Therapeutic Implications

Joseph, M., & Enting, D. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01270 · Cited by 120 · see citing works

Axl, A Receptor Tyrosine Kinase, Mediates Flow-Induced Vascular Remodeling

Korshunov, V. A., Mohan, A. M., Georger, M. A., & Berk, B. C. (2006) · Circulation Research · doi:10.1161/01.res.0000223322.16149.9a · Cited by 116 · see citing works

Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK)

Rochlitz, C. F., Lohri, A., Bacchi, M., Schmidt, M., Nagel, S., Fopp, M., Fey, M., Herrmann, R., & Neubauer, A. (1999) · Leukemia · doi:10.1038/sj.leu.2401484 · Cited by 115 · see citing works

Signaling cross-talk in the resistance to HER family receptor targeted therapy

Yamaguchi, H., Chang, S. H., Hsu, J. L., & Hung, M. (2013) · Oncogene · doi:10.1038/onc.2013.74 · Cited by 115 · see citing works

Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors

Chen, F. L., Xia, W., & Spector, N. L. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0581 · Cited by 112 · see citing works

Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy

Leconet, W., Larbouret, C., Chardès, T., Thomas, G., Neiveyans, M., Busson, M., Jarlier, M., Radosevic‐Robin, N., Pugnière, M., Bernex, F., et al. (2013) · Oncogene · doi:10.1038/onc.2013.487 · Cited by 107 · see citing works

Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells

Vouri, M., Croucher, D. R., Kennedy, S. P., An, Q., Pilkington, G. J., & Hafizi, S. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.66 · Cited by 106 · see citing works

Overexpression of MERTK Receptor Tyrosine Kinase in Epithelial Cancer Cells Drives Efferocytosis in a Gain-of-Function Capacity

Nguyen, K.-Q. N., Tsou, W., Calarese, D. A., Kimani, S. G., Singh, S., Hsieh, S., Liu, Y., Lü, B., Wu, Y., Garforth, S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.570838 · Cited by 99 · see citing works

p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

Tian, L., Choi, S., Murakami, Y., Allen, J. N., Morse, H. C., Qi, C., Krzewski, K., & Coligan, J. E. (2014) · Nature Communications · doi:10.1038/ncomms4146 · Cited by 98 · see citing works

AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers

Balaji, K., Vijayaraghavan, S., Diao, L., Tong, P., Fan, Y.-H., Carey, J. P. W., Bui, T. N., Warner, S. L., Heymach, J. V., Hunt, K. K., et al. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0157 · Cited by 98 · see citing works

Crosstalk between ERK, AKT, and cell survival

Dent, P. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.27541 · Cited by 97 · see citing works

Efferocytosis: molecular mechanisms and pathophysiological perspectives

Hayat, S. M. G., Bianconi, V., Pirro, M., & Sahebkar, A. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12206 · Cited by 97 · see citing works

MFG-E8/Lactadherin Promotes Tumor Growth in an Angiogenesis-Dependent Transgenic Mouse Model of Multistage Carcinogenesis

Neutzner, M., Lopez, T., Xu, F., Bergmann‐Leitner, E. S., Leitner, W. W., & Udey, M. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0165 · Cited by 96 · see citing works

Milk fat globule epidermal growth factor–8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms

Jinushi, M., Sato, M., Kanamoto, A., Itoh, A., Nagai, S., Koyasu, S., Dranoff, G., & Tahara, H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082614 · Cited by 95 · see citing works

CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition

Murakami, Y., Tian, L., Voss, O. H., Margulies, D. H., Krzewski, K., & Coligan, J. E. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.86 · Cited by 94 · see citing works

Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment

Kumar, S., Calianese, D. C., & Birge, R. B. (2017) · Immunological Reviews · doi:10.1111/imr.12587 · Cited by 92 · see citing works

Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1

Werfel, T. A., Elion, D. L., Rahman, B., Hicks, D. J., Sanchez, V. M., Ericsson, P. I. G., Nixon, M. J., James, J. L., Balko, J. M., Scherle, P., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1106 · Cited by 92 · see citing works

Treatment with annexin V increases immunogenicity of apoptotic human T-cells in Balb/c mice

Stach, C. M., Turnay, J., Voll, R. E., Kern, P. M., Kolowos, W., Beyer, T. D., Kalden, J. R., & i, M. H. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400715 · Cited by 89 · see citing works

MFG-E8 Drives Melanoma Growth by Stimulating Mesenchymal Stromal Cell–Induced Angiogenesis and M2 Polarization of Tumor-Associated Macrophages

Yamada, K., Uchiyama, A., Uehara, A., Perera, B., Ogino, S., Yokoyama, Y., Takeuchi, Y., Udey, M. C., Ishikawa, O., & Motegi, S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2812 · Cited by 87 · see citing works

Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl

Paccez, J. D., Duncan, K., Sekar, D., Correa, R. G., Wang, Y., Gu, X., Bashin, M., Chibale, K., Libermann, T. A., & Zerbini, L. F. (2019) · Oncogenesis · doi:10.1038/s41389-019-0122-6 · Cited by 81 · see citing works

ICAM-1 Has a Critical Role in the Regulation of Metastatic Melanoma Tumor Susceptibility to CTL Lysis by Interfering with PI3K/AKT Pathway

Hamaï, A., Meslin, F., Benlalam, H., Jalil, A., Mehrpour, M., Faure, F., Lécluse, Y., Vielh, P., Avril, M., Robert, C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0719 · Cited by 81 · see citing works

Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells

Fens, M. H. A. M., Mastrobattista, E., de Graaff, A. M., Flesch, F. M., Ultee, A., Rasmussen, J. T., Molema, G., Storm, G., & Schiffelers, R. M. (2008) · Blood · doi:10.1182/blood-2007-06-094763 · Cited by 80 · see citing works

Macrophage-Derived Neuropilin-2 Exhibits Novel Tumor-Promoting Functions

Roy, S., Bag, A. K., Dutta, S., Polavaram, N. S., Islam, R., Schellenburg, S., Banwait, J., Guda, C., Ran, S., Hollingsworth, M. A., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0562 · Cited by 80 · see citing works

Targeting AXL overcomes resistance to docetaxel therapy in advanced prostate cancer

Lin, J., Wang, Z., De, W., Zheng, M., Xu, W., Wu, H., Armstrong, A., & Zhu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.17026 · Cited by 79 · see citing works

Phase I Safety and Pharmacokinetic Study of Bavituximab, a Chimeric Phosphatidylserine-Targeting Monoclonal Antibody, in Patients with Advanced Solid Tumors

Gerber, D. E., Stopeck, A., Wong, L., Rosen, L. S., Thorpe, P. E., Shan, J. S., & Ibrahim, N. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1074 · Cited by 73 · see citing works

Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer

Knocke, S., Fleischmann-Mundt, B., Saborowski, M., Manns, M. P., Kühnel, F., Wirth, T. C., & Woller, N. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.086 · Cited by 70 · see citing works

Intracellular HMGB1 Negatively Regulates Efferocytosis

Banerjee, S., de Freitas, A., Friggeri, A., Zmijewski, J. W., Liu, G., & Abraham, E. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101500 · Cited by 68 · see citing works

MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents

McDaniel, N. K., Cummings, C. T., Iida, M., Huelse, J. M., Pearson, H. E., Vasileiadi, E., Parker, R. E., Orbuch, R. A., Ondracek, O. J., Welke, N. B., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-1239 · Cited by 66 · see citing works

Anexelekto (AXL) Increases Resistance to EGFR-TKI and Activation of AKT and ERK1/2 in Non-Small Cell Lung Cancer Cells

Tian, Y., Zhang, Z., Miao, L., Yang, Z., Yang, J., Wang, Y., Qian, D., Cai, H., & Wang, Y. (2016) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504016x14648701447814 · Cited by 61 · see citing works

Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non–Small Cell Lung Cancer

Kawada, I., Hasina, R., Arif, Q., Mueller, J. S., Smithberger, E., Husain, A. N., Vokes, E. E., & Salgia, R. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3583 · Cited by 59 · see citing works

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo

Onken, J., Torka, R., Korsing, S., Radke, J., Krementeskaia, I., Nieminen-Kelhä, M., Bai, X., Ullrich, A., Heppner, F. L., & Vajkoczy, P. (2016) · Oncotarget · doi:10.18632/oncotarget.7130 · Cited by 59 · see citing works

Milk fat globule—epidermal growth factor—factor VIII (MFGE8)/lactadherin promotes bladder tumor development

Sugano, G., Bernard‐Pierrot, I., Lae, M. E., Battail, C., Allory, Y., Stransky, N., Krumeich, S., Lepage, M.-L., Maille, P., Donnadieu, M.-H., et al. (2010) · Oncogene · doi:10.1038/onc.2010.446 · Cited by 57 · see citing works

Apoptotic Cells of an Epithelial Cell Line, AsPC-1, Release Monocyte Chemotactic S19 Ribosomal Protein Dimer

Nishimura, T., Horino, K., Nishiura, H., Shibuya, Y., Hiraoka, T., Tanase, S., & Yamamoto, T. (2001) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002876 · Cited by 57 · see citing works

Development of Bavituximab, a Vascular Targeting Agent with Immune-Modulating Properties, for Lung Cancer Treatment

DeRose, P. M., Thorpe, P. E., & Gerber, D. E. (2011) · Immunotherapy · doi:10.2217/imt.11.87 · Cited by 56 · see citing works

The influence on the immunomodulatory effects of dying and dead cells of Annexin V

Munoz, L. E., Franz, S., Pausch, F., Fürnrohr, B. G., Sheriff, A., Vogt, B., Kern, P. M., Baum, W., Stach, C. M., von Laer, D., et al. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306166 · Cited by 55 · see citing works

Identification of MFG-E8 as a novel therapeutic target for diseases

Li, B., Zhang, H.-Y., Pan, H., & Ye, D. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.829455 · Cited by 53 · see citing works

A phase I clinical trial of bavituximab and paclitaxel in patients with HER2 negative metastatic breast cancer

Chalasani, P., Marron, M., Roe, D. J., Clarke, K., Iannone, M., Livingston, R. B., Shan, J. S., & Stopeck, A. (2015) · Cancer Medicine · doi:10.1002/cam4.447 · Cited by 45 · see citing works

Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

Tian, L., Choi, S.-C., Lee, H., Murakami, Y., Qi, C.-F., Sengottuvelu, M., Voss, O., Krzewski, K., & Coligan, J. E. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.161 · Cited by 45 · see citing works

TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner

Zhang, Q., Wang, H., Wu, X., Liu, B., Liu, W., Wang, R., Liang, X., Ma, C., & Gao, L. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.323 · Cited by 44 · see citing works

Inhibitory role of Gas6 in intestinal tumorigenesis

Akitake, R., Seno, H., Nakatsuji, M., Kimura, Y., Nakanishi, Y., Yoshioka, T., Kanda, K., Kawada, M., Kawada, K., Sakai, Y., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt069 · Cited by 42 · see citing works

Bavituximab plus paclitaxel and carboplatin for the treatment of advanced non-small-cell lung cancer

Digumarti, R., Bapsy, P. P., Suresh, A. V., Bhattacharyya, G. S., Dasappa, L., Shan, J. S., & Gerber, D. E. (2014) · Lung Cancer · doi:10.1016/j.lungcan.2014.08.010 · Cited by 41 · see citing works

Homozygous Mutation in MERTK Causes Severe Autosomal Recessive Retinitis Pigmentosa

Ksantini, M., Lafont, E., Bocquet, B., Meunier, I., & Hamel, C. (2011) · European Journal of Ophthalmology · doi:10.5301/ejo.5000096 · Cited by 39 · see citing works

Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer

Mancini, M., Gaborit, N., Lindzen, M., Salame, T. M., Dall’Ora, M., Sevilla-Sharon, M., Abdul‐Hai, A., Downward, J., & Yarden, Y. (2015) · Science Signaling · doi:10.1126/scisignal.aaa0725 · Cited by 38 · see citing works

MERTK Promotes Resistance to Irreversible EGFR Tyrosine Kinase Inhibitors in Non–small Cell Lung Cancers Expressing Wild-type EGFR Family Members

Yan, D., Parker, R. E., Wang, X., Frye, S. V., Earp, H. S., DeRyckere, D., & Graham, D. K. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0040 · Cited by 33 · see citing works

Expression of milk fat globule epidermal growth factor-VIII may be an indicator of poor prognosis in malignant melanoma

Oba, J., Moroi, Y., Nakahara, T., Abe, T., Hagihara, A., & Furue, M. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10409.x · Cited by 32 · see citing works

Efferocytosis of apoptotic human papillomavirus‐positive cervical cancer cells by human primary fibroblasts

Hermetet, F., Jacquin, É., Launay, S., Gaiffe, É., Couturier, M., Hirchaud, F., Sandoz, P., Prétet, J., & Mougin, C. (2016) · Biology of the Cell · doi:10.1111/boc.201500090 · Cited by 32 · see citing works

A novel human anti‐AXL monoclonal antibody attenuates tumour cell migration

Duan, Y., Luo, L., Qiao, C., Li, X., Wang, J., Liu, H., Zhou, T., Shen, B., Lv, M., & Feng, J. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12777 · Cited by 26 · see citing works

Prognostic Correlation Between MFG-E8 Expression Level and Colorectal Cancer

Jia, M., Yao, H., Chen, C., Wang, Y., Wang, H., Cui, T., & Zhu, J. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.06.003 · Cited by 24 · see citing works

Docetaxel Combined With Bavituximab in Previously Treated, Advanced Nonsquamous Non–Small-Cell Lung Cancer

Gerber, D. E., Spigel, D. R., Giorgadze, D., Shtivelband, M. I., Ponomarova, O. V., Shan, J. S., Menander, K. B., & Belani, C. P. (2016) · Clinical Lung Cancer · doi:10.1016/j.cllc.2016.02.003 · Cited by 23 · see citing works

Expression of milk fat globule epidermal growth factor-VIII may be an indicator of poor prognosis in malignant melanoma

大場, 純. (2012) · Cited by 21 · see citing works

Immunoregulatory influence of abundant MFG ‐E8 expression by esophageal cancer treated with chemotherapy

Kanemura, T., Miyata, H., Makino, T., Tanaka, K., Sugimura, K., Hamada‐Uematsu, M., Mizote, Y., Uchida, H., Miyazaki, Y., Takahashi, T., et al. (2018) · Cancer Science · doi:10.1111/cas.13785 · Cited by 18 · see citing works

MFG-E8 overexpression is associated with poor prognosis in breast cancer patients

Yu, L., Zhao, L., Jia, Z., Bi, J., Wei, Q., Song, X., Jiang, L., Lin, S., & Wei, M. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.12.036 · Cited by 17 · see citing works

Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells

Lee, Y., Kim, S., & Lee, C. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.9957 · Cited by 13 · see citing works

Down-regulation of MFG-E8 by RNA interference combined with doxorubicin triggers melanoma destruction

Zhao, J., Ma, X., Li, Z., Deng, R., Wang, S.-M., Shen, G., Zhang, J., Wang, F., Zhang, B., & Wei, Y.-Q. (2014) · Clinical and Experimental Medicine · doi:10.1007/s10238-014-0277-6 · Cited by 9 · see citing works

Untitled work

Good (1996) · doi:10.1002/(sici)1097-4652(199609)168:3

Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention

Zhou, X., Liu, X., & Huang, L. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202006220 · Cited by 145 · see citing works

Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity

Zhuang, W., Wang, Y., Nie, W., Yao, L., Liang, C., He, J., Zuo, L., Huang, L.-L., & Xie, H. (2023) · Nature Communications · doi:10.1038/s41467-023-37369-0 · Cited by 114 · see citing works

Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications

Wang, H., Liu, Z., Shao, J., Lin, L., Jiang, M., Wang, L., Lu, X.-C., Zhang, H. S., Chen, Y., & Zhang, R. (2020) · Journal of Immunology Research · doi:10.1155/2020/4904217 · Cited by 114 · see citing works

The ABCA1-efferocytosis axis: A new strategy to protect against atherosclerosis

Chen, W., Li, L., Wang, J., Zhang, R., Zhang, T., Wu, Y., Wang, S., & Xing, D. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.02.025 · Cited by 84 · see citing works

Efferocytosis: An accomplice of cancer immune escape

Qiu, H., Shao, Z., Wen, X., Liu, Z., Chen, Z., Qu, D., Ding, X., & Zhang, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115540 · Cited by 55 · see citing works

LC3-associated phagocytosis (LAP): a potentially influential mediator of efferocytosis-related tumor progression and aggressiveness

Asare, P. F., Roscioli, E., Hurtado, P. R., Tran, H. B., Mah, C. Y., & Hodge, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01298 · Cited by 50 · see citing works

An imbalance of the IL-33/ST2-AXL-efferocytosis axis induces pregnancy loss through metabolic reprogramming of decidual macrophages

Sheng, Y., Hu, W., Shen, H., Wei, C., Liu, Y., Ma, X.-Q., Li, M., & Zhu, X. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04197-2 · Cited by 47 · see citing works

Overnutrition and Lipotoxicity: Impaired Efferocytosis and Chronic Inflammation as Precursors to Multifaceted Disease Pathogenesis

Mann, V., Sundaresan, A., & Shishodia, S. (2024) · Biology · doi:10.3390/biology13040241 · Cited by 41 · see citing works

Efferocytosis Nanoinhibitors to Promote Secondary Necrosis and Potentiate the Immunogenicity of Conventional Cancer Therapies for Improved Therapeutic Benefits

Wu, Y., Wang, C., Yan, Y., Hao, Y., Liu, B., Dong, Z., Chen, M., Zhu, Y., Liu, N., Feng, L., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c04884 · Cited by 38 · see citing works

Dys-regulated phosphatidylserine externalization as a cell intrinsic immune escape mechanism in cancer

Pulica, R., Aquib, A., Varsanyi, C., Gadiyar, V., Wang, Z., Frederick, T., Calianese, D. C., Patel, B., de Dios, K. V., Poalasin, V., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02090-6 · Cited by 40 · see citing works

RNA-based modulation of macrophage-mediated efferocytosis potentiates antitumor immunity in colorectal cancer

Zhou, X., Li, D., Xia, S., Ma, X., Li, R., Mu, Y., Liu, Z., Zhang, L., Zhou, Q., Zhuo, W., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.018 · Cited by 35 · see citing works

Endothelial Senescence and Chronic Fatigue Syndrome, a COVID-19 Based Hypothesis

Sfera, A., Osorio, C. P., del Campo, C. M. Z.-M., Pereida, S., Maurer, S., Maldonado, J. C., & Kozlakidis, Z. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.673217 · Cited by 34 · see citing works

Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Ma, Z., Sun, Y. L., Yu, Y., Xiao, W., Xiao, Z., Zhong, T., Xiang, X., & Li, Z. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01669-9 · Cited by 32 · see citing works

Interaction, immune infiltration characteristics and prognostic modeling of efferocytosis-related subtypes in glioblastoma

Zhao, S., Wang, Q., Liu, Y., Zhang, P., Ji, W., Xie, J., & Cheng, C. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01688-4 · Cited by 30 · see citing works

Molecular Mechanisms of Tumor Immunomodulation in the Microenvironment of Colorectal Cancer

Plundrich, D., Chikhladze, S., Fichtner‐Feigl, S., Feuerstein, R., & Briquez, P. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052782 · Cited by 31 · see citing works

Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression

Sun, Y. L., Xiao, W., Yu, Y., Jiang, Y., Xiao, Z., Huang, D., Zhong, T., Li, J., Xiang, X., He, Y., et al. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113565 · Cited by 25 · see citing works

Immunological role of TAM receptors in the cancer microenvironment

Gadiyar, V., Patel, G., & Davra, V. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.09.011 · Cited by 26 · see citing works

Efferocytosis Drives Myeloid NLRP3 Dependent Inflammasome Signaling and Gasdermin D Independent Secretion of IL-1β to Promote Tumor Growth

Lang, C., Roy, S., Wang, Y., Graves, D. K., Xu, Y., Serezani, C. H., Korrer, M. J., & Kim, Y. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.993771 · Cited by 24 · see citing works

TAM kinases as regulators of cell death

Post, S. M., Andreeff, M., Dinardo, C. D., Khoury, J. D., & Ruvolo, P. P. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.118992 · Cited by 21 · see citing works

The DNA damage response pathway regulates the expression of the immune checkpoint CD47

Ghantous, L., Volman, Y., Hefez, R., Wald, O., Stern, E., Friehmann, T., Chajut, A., Bremer, E., Elhalel, M. D., & Rachmilewitz, J. (2023) · Communications Biology · doi:10.1038/s42003-023-04615-6 · Cited by 23 · see citing works

Efferocytosis: the art of cellular clearance and novel perspectives in disease therapy

Li, G., Xu, J., Tian, X., Xiao, J., Long, J., Chen, Y., Shen, W., & Zhao, S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02484-7 · Cited by 25 · see citing works

Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation

Mao, Y. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.10.002 · Cited by 21 · see citing works

Leveraging efferocytosis blockade for improved cancer chemo-immunotherapy through synchronized release of doxorubicin and BMS777607 confined within tailored mesoporous silica nanoparticles

Zhang, J., Chen, F., Li, Y., Duan, Q.-J., Wu, C., Zheng, S.-J., Leong, K. W., Shao, D., & Du, J. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102039 · Cited by 21 · see citing works

The expression and significance of efferocytosis and immune checkpoint related molecules in pancancer samples and the correlation of their expression with anticancer drug sensitivity

Cheng, L., Weng, B., Jia, C., Zhang, L., Hu, B., Deng, L., Mou, N., Sun, F., & Hu, J. Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.977025 · Cited by 20 · see citing works

Integrating Bulk RNA and Single-Cell Sequencing Data Unveils Efferocytosis Patterns and ceRNA Network in Ischemic Stroke

Yuan, J., Liao, Y.-S., Zhang, T.-C., Tang, Y.-Q., Yu, P., Liu, Y., Cai, D., Yu, S., & Zhao, L. (2024) · Translational Stroke Research · doi:10.1007/s12975-024-01255-8 · Cited by 20 · see citing works

Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions

Han, M., Ryu, G., Shin, S.-A., An, J., Kim, H., Park, D., Lee, D.-H., & Lee, C. S. (2021) · Life · doi:10.3390/life11111141 · Cited by 18 · see citing works

Differential Macrophage Responses to Gold Nanostars and Their Implication for Cancer Immunotherapy

Kenry, K., Eschle, B. K., Andreiuk, B., Gokhale, P. C., & Mitragotri, S. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202100198 · Cited by 17 · see citing works

Efferocytosis and the Story of “Find Me,” “Eat Me,” and “Don’t Eat Me” Signaling in the Tumor Microenvironment

Banerjee, H. N., Bartlett, V., Krauss, C., Aurelius, C., Johnston, K., Hedley, J., & Verma, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-73119-9_8 · Cited by 17 · see citing works

Immuno-oncology: are TAM receptors in glioblastoma friends or foes?

Zhou, Y., Wang, Y., Chen, H., Xu, Y., Luo, Y., Deng, Y., Zhang, J., & Shao, A. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-020-00694-8 · Cited by 17 · see citing works

7S,15R-Dihydroxy-16S,17S-Epoxy-Docosapentaenoic Acid, a Novel DHA Epoxy Derivative, Inhibits Colorectal Cancer Stemness through Repolarization of Tumor-Associated Macrophage Functions and the ROS/STAT3 Signaling Pathway

Wang, L., Choi, H. S., Su, Y., Lee, B., Song, J., Jang, Y., & Seo, J. (2021) · Antioxidants · doi:10.3390/antiox10091459 · Cited by 15 · see citing works

Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis

Gao, P., Wang, J., Tang, H., Pang, H., Liu, J., Wang, C., Xia, F., Chen, H., Xu, L., Zhang, J., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01409-5 · Cited by 14 · see citing works

Integration of the bulk transcriptome and single-cell transcriptome reveals efferocytosis features in lung adenocarcinoma prognosis and immunotherapy by combining deep learning

Xie, Y., Chen, H., Zhang, X., Zhang, J., Zhang, K., Wang, X., Min, S., Wang, X., & Lian, C. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03571-3 · Cited by 14 · see citing works

Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach

Ji, X., Qian, X., Luo, G., Yang, W., Huang, W., Lei, Z., Zhou, J., Zhong, G., Zhou, J., Liu, N., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.01.012 · Cited by 14 · see citing works

Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration

Zhang, Y., Nie, R., Feng, Z.-Y., Fan, M., Shen, Z., Zhang, X., Zhang, Q., Zou, C., Zhang, J., Huang, K., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.05.026 · Cited by 13 · see citing works

Combining bulk and scRNA‐seq to explore the molecular mechanisms governing the distinct efferocytosis activities of a macrophage subpopulation in PDAC

Zhu, S., Cheng, Q., Zou, M., Li, C., Tang, Y., Xia, L., Jiang, Y., Gong, Z., Tang, Z., Tang, Y., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18266 · Cited by 13 · see citing works

The TRIM28/miR133a/CD47 axis acts as a potential therapeutic target in pancreatic necrosis by impairing efferocytosis

Zhu, Q., Yuan, C., Wang, D., Tu, B., Chen, W., Dong, X., Wu, K., Tao, L., Ding, Y., Xiao, W., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.06.005 · Cited by 13 · see citing works

Efferocytosis in Health and Disease

Li, C., Yang, Y., Zhou, F., Jiang, Q., Jiang, Y., Huang, X., Zhang, Y., Ye, Z., Xu, G. X., Kao, G., et al. (2025) · MedComm · doi:10.1002/mco2.70546 · Cited by 15 · see citing works

Identification of efferocytosis-related subtypes in gliomas and elucidating their characteristics and clinical significance

Gao, M., Huang, J., Yang, B., Liu, Q., Luo, M., Yang, B., Li, X., & Liu, X. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1295891 · Cited by 12 · see citing works

Efferocytosis: a double-edged sword in microbial immunity

Mohammad‐Rafiei, F., Moadab, F., Mahmoudi, A. A., Navashenaq, J. G., & Hayat, S. M. G. (2023) · Archives of Microbiology · doi:10.1007/s00203-023-03704-8 · Cited by 10 · see citing works

Crosstalk between efferocytic myeloid cells and T-cells and its relevance to atherosclerosis

Ngai, D., Sukka, S. R., & Tabas, I. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1403150 · Cited by 10 · see citing works

The intricate interplay between ferroptosis and efferocytosis in cancer: unraveling novel insights and therapeutic opportunities

Firouzjaei, A. A., & Mohammadi‐Yeganeh, S. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1424218 · Cited by 10 · see citing works

Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus

Yoshida, S., Hamada, Y., Narita, M., Sato, D., Tanaka, K., Mori, T., Tezuka, H., Suda, Y., Tamura, H., Aoki, K., et al. (2023) · Molecular Brain · doi:10.1186/s13041-023-01006-0 · Cited by 10 · see citing works

The outer membrane protein Tp92 of Treponema pallidum delays human neutrophil apoptosis via the ERK , PI3K / Akt , and NF‐κB pathways

Li, W., Li, S., Wang, J., Yu, M., Yang, H., He, Z., Tang, Y., Liu, J., Guo, N., Xie, D., et al. (2023) · Molecular Microbiology · doi:10.1111/mmi.15164 · Cited by 9 · see citing works

Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells

Bendre, S. V., Wang, Y., Hajyousif, B., K C, R., Bhogale, S. G., Pradeep, D., Krawczynska, N., Schane, C. P., Weisser, E., Singh, A., et al. (2026) · Science Advances · doi:10.1126/sciadv.adx5490 · Cited by 8 · see citing works

Efferocytosis signatures as prognostic markers for revealing immune landscape and predicting immunotherapy response in hepatocellular carcinoma

Xu, K., Liu, Y. S., Luo, H., & Wang, T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1218244 · Cited by 8 · see citing works

Molecular profiling of TAM tyrosine kinase receptors and ligands in endometrial carcinoma: An in silico-study

Akın, D. F., & Özkan, D. (2023) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2022.09.010 · Cited by 7 · see citing works

Phosphatidylserine accelerates wound healing and reduces necrosis in the rats: Growth factor activation

Saffari, P. M., Asili, P., Eshraghi, S., Muhammadnejad, A., Dehpour, A. R., Goudarzi, R., & Partoazar, A. (2024) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13849 · Cited by 7 · see citing works

Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y. Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-02992-2 · Cited by 7 · see citing works

Plant‐Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer

Wang, H., Wang, X., Wang, L., Wang, H., & Zhang, Y. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400197 · Cited by 5 · see citing works

A novel molecular classification based on efferocytosis-related genes for predicting clinical outcome and treatment response in acute myeloid leukemia

Zhong, F., Yao, F., Qin, B., Liu, J. L., Li, X., Huang, B., & Wang, X. (2024) · Inflammation Research · doi:10.1007/s00011-024-01938-w · Cited by 5 · see citing works

Single-cell transcriptomic analysis reveals efferocytosis signature predicting immunotherapy response in hepatocellular carcinoma

Li, L., Li, G., & Zhai, W. (2025) · Digestive and Liver Disease · doi:10.1016/j.dld.2025.01.196 · Cited by 5 · see citing works

Directing Hypoxic Tumor Microenvironment and HIF to Illuminate Cancer Immunotherapy's Existing Prospects and Challenges in Drug Targets

Ray, S. K., & Mukherjee, S. (2022) · Current Drug Targets · doi:10.2174/1389450123666220111114649 · Cited by 6 · see citing works

Macrophage polarization in tumors: The impact of efferocytosis.

Zhang, Y., Zang, H., & Wen, Q.-Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115807 · Cited by 5 · see citing works

Combination of Niclosamide with Immunogenic Cell Death-Inducer Delivered by Nanoparticles for Breast Cancer Therapy by Disturbing Pro-survival Autophagy and Efferocytosis

Sun, Q., Yang, W., Li, Y., Song, Z., Shen, W. H., Yang, Y., & Yin, D. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c00985 · Cited by 4 · see citing works

Targeting lipid metabolism to overcome tamoxifen resistance in breast cancer: Evaluating the synergistic therapeutic potential of quercetin

Rifaat, R. M., Kamel, M., Sharaky, M. M., Attia, Y. M., & Shouman, S. A. (2025) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2025.100953 · Cited by 3 · see citing works

ALOX15B-based efferocytosis clusters: prognostic implications and immune cell infiltration in breast cancer

Chen, J., Zheng, C., Zhang, F., Sun, S., Liu, G., & Huang, G. C. (2025) · Discover Oncology · doi:10.1007/s12672-025-02961-x · Cited by 3 · see citing works

Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy

Li, M., Dong, W., Cui, Y., Li, J., Yang, C., Zhang, D., & Fu, X. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102233 · Cited by 3 · see citing works

Death as rebirth: how efferocytosis drives tissue repair and disease treatment

Duan, X., Han, S., Bian, Y., Yuan, Y., Shen, J., Dai, Y., Mi, J., & Wang, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1712547 · Cited by 3 · see citing works

Clinical significance of lipid pathway-targeted therapy in breast cancer

Li, D., Jin, P., Cai, Y., Wu, S., Guo, X., Zhang, Z., Liu, K., Li, P., Hu, Y., & Zhou, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1514811 · Cited by 3 · see citing works

Efferocytosis-related gene IL33 predicts prognosis and immune response and mediates proliferation and migration in vitro and in vivo of breast cancer

Xiao, H., Cheng, X., Zhang, Z., Chen, L., Xie, C., & Tang, M. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1533571 · Cited by 3 · see citing works

SNRPB and CEP290, predicting the prognosis of diffuse large B cell lymphoma and associated with tumour immune microenvironment

Tang, J. Y., Lü, B., Bin, T., Xu, X., Lin, C., Wang, Y., & Xie, W. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2425065 · Cited by 3 · see citing works

A prognostic pyroptosis-related LncRNA classifier associated with the immune landscape and therapy efficacy in glioma

Zhong, J., Liu, J., Huang, Z., Zheng, Y., Chen, J. C., Ji, J., Chen, T., & Ke, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1026192 · Cited by 2 · see citing works

Establishment of a novel efferocytosis potential index predicts prognosis and immunotherapy response in cancers

Chen, P., Li, Z., & Li, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30337 · Cited by 2 · see citing works

Mapping the evolving trend of research on efferocytosis: a comprehensive data-mining-based study

Jian, Y., Dong, S., Liu, W., Li, G., Lian, X., & Wang, Y. (2025) · BioData Mining · doi:10.1186/s13040-025-00475-4 · Cited by 2 · see citing works

Mapping the knowledge structure and emerging trends of efferocytosis research: a bibliometric analysis.

Lv, H., Hua, Q., Wang, Y., Gao, Z., Liu, P., Qin, D., & Xu, Y. (2023) · PubMed Central · Cited by 2 · see citing works

β-glucan reprograms macrophages to attenuate efferocytosis of cancer cellsPreprint

Chatzis, A., Lukaszonek, J., Lagos, D., Boucher, D., & Kourtzelis, I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.11.622862 · Cited by 2 · see citing works

Efferocytosis-associated genes serve as prognostic biomarkers for pancreatic ductal adenocarcinoma and identify P2RY6 as a therapeutic target

Wang, X., Wang, W., Yang, C., Wang, P., Liu, Y., Yu, L., Zhang, S., Yan, X., & Wang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1708441 · Cited by 1 · see citing works

Integration of Machine Learning Algorithms and Single‐Cell Sequencing Analysis Reveals the Efferocytosis‐Related Molecular Subtype and Prognostic Scoring Index in Colon Adenocarcinoma

Ju, K., Liu, X., Wang, Q., Liu, X., Li, D., & Tan, B. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16985 · Cited by 1 · see citing works

Drivers of EMT and Immune Evasion

Brekken, R. A., & Wnuk-Lipińska, K. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_11 · Cited by 1 · see citing works

β-glucan reprograms macrophages to attenuate efferocytosis of cancer cellsPreprint

Chatzis, A., Lukaszonek, J., Lagos, D., Boucher, D., & Kourtzelis, I. (2025) · eLife · doi:10.7554/elife.105206.2 · Cited by 1 · see citing works

Exploring the anticancer activity of five Hyalomma species (Acari: Ixodidae) salivary gland extracts on human colorectal cancer cell line HT-29Preprint

Tavassoli, M., Kadivar, M., Akhavan, A. A., Abdigoudarzi, M., Chaibakhsh, S., Beik-Mohammadi, M., & Sedaghat, M. M. (2022) · Research Square · doi:10.21203/rs.3.rs-1970199/v1

C3d(g), iron nanoparticles, hemin and cytochrome c may induce oxidative cytotoxicity in tumors and reduce tumor-associated myeloid cells-mediated immunosuppression

Kavvadas, E. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110944

Trained innate immunity attenuates macrophage efferocytosis of cancer cellsPreprint

Chatzis, A., Lukaszonek, J., Lagos, D., Boucher, D., & Kourtzelis, I. (2025) · eLife · doi:10.7554/elife.105206.1

β-glucan reprograms macrophages to attenuate efferocytosis of cancer cellsPreprint

Chatzis, A., Lukaszonek, J., Lagos, D., Boucher, D., & Kourtzelis, I. (2025) · eLife · doi:10.7554/elife.105206

Inhibition of AXL dependent non-professional efferocytosis sensitizes pancreatic cancer to immune checkpoint blockadePreprint

Park, J. Y., McCaw, T. R., Dao, H., Donahue, T. R., Crompton, J., Vlashi, E., & Girgis, M. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.12.669943

Development of a prognostic RiskScore model using efferocytosis-related signature genes for lung adenocarcinoma

Dai, Z., Jin, S., Huang, S., Liu, B., Shen, X., & Jin, Y. (2025) · PeerJ · doi:10.7717/peerj.19892

Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21Preprint

Giri, S., Selvadurai, B.-R., Nieves, A. S., Gupta, N., Lindzen, M., Chatterjee, R., Genna, A., Daele, M. V., Ramesh-Kumar, D., Zerbib, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.16.681972

Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers

Zhao, J., Liu, X., Sun, Q., He, Y., Wang, J., Liu, J., Li, C., Yan, F., Jin, H., Xue, Z., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0334163

Construction and accuracy assessment of an efferocytosis-related prognostic model for ovarian cancer: A diagnostic accuracy study

Yuan, X., Hu, J., Li, N., He, P., Wang, D., Liu, Y., & Yajuan, L. (2025) · Medicine · doi:10.1097/md.0000000000045324

Additional file 7 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26689511

Additional file 6 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26689508

Additional file 1 of Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Ma, Z., Sun, Y., Yu, Y., Xiao, W., Xiao, Z., Zhong, T., Xiang, X., & Li, Z. (2024) · Figshare · doi:10.6084/m9.figshare.25909927

Additional file 5 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26689505

Additional file 4 of Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Ma, Z., Sun, Y., Yu, Y., Xiao, W., Xiao, Z., Zhong, T., Xiang, X., & Li, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26726273

Additional file 8 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26689514

Additional file 3 of Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Ma, Z., Sun, Y., Yu, Y., Xiao, W., Xiao, Z., Zhong, T., Xiang, X., & Li, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26726270

Additional file 1 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25347080

Additional file 2 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25347292

Additional file 4 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26689502

Additional file 1 of Interaction, immune infiltration characteristics and prognostic modeling of efferocytosis-related subtypes in glioblastoma

Zhao, S., Wang, Q., Liu, Y., Zhang, P., Ji, W., Xie, J., & Cheng, C. (2024) · Figshare · doi:10.6084/m9.figshare.26628304

Additional file 2 of Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Ma, Z., Sun, Y., Yu, Y., Xiao, W., Xiao, Z., Zhong, T., Xiang, X., & Li, Z. (2024) · Figshare · doi:10.6084/m9.figshare.25910168

Additional file 2 of Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus

Yoshida, S., Hamada, Y., Narita, M., Sato, D., Tanaka, K., Mori, T., Tezuka, H., Suda, Y., Tamura, H., Aoki, K., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22600334

Additional file 1 of Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus

Yoshida, S., Hamada, Y., Narita, M., Sato, D., Tanaka, K., Mori, T., Tezuka, H., Suda, Y., Tamura, H., Aoki, K., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22600331

Additional file 3 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26689499

Additional file 9 of Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy

Hu, Y., Revenko, A. S., Barsoumian, H. B., Bertolet, G., Fowlkes, N. W., Maazi, H., Green, M. M., He, K., Sezen, D., Voss, T. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26689517

YiQi-HuoXue prescription ameliorates LPS-induced sepsis-associated encephalopathy via VCAM-1–mediated microglial efferocytosis

Wang, Z., Song, E., Wang, Y., & Lu, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1792688

Efferocytosis-related biomarkers and immune infiltration in pancreatic ductal adenocarcinoma based on single-cell sequencing and machine learning: a comprehensive bioinformatics analysis and experimental validation

Huang, S., Gu, D., & Xiong, W. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153751

Microparticle uptake reduces efferocytic capacity of macrophages

Mishra, S., Aggarwal, B., Anant, P. S., Bajaj, A., & Jhunjhunwala, S. (2026) · Biomaterials Science · doi:10.1039/d5bm01447f

Construction of an efferocytosis related signature to predict the prognosis of pancreatic ductal adenocarcinoma

Li, J., Du, Z., Liu, X., Pan, T., Zheng, Y., & He, Y. (2026) · Discover Oncology · doi:10.1007/s12672-026-05088-9

Nanomedicine-enabled reprogramming of macrophage trained immunity to modulate cancer stem cells fate

Li, Y., Ge, Z., Sun, Y., Miao, L., Wang, P., Zhao, Y., Chai, S., Fan, B., Li, Y., Huang, W., et al. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.113105

The complex roles of efferocytosis in cancer development, metastasis, and treatment

Tajbakhsh, A., Gheibi hayat, S. M., Movahedpour, A., Savardashtaki, A., Loveless, R., Barreto, G. E., Teng, Y., & Sahebkar, A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111776 · Cited by 64 · see citing works

Efferocytosis: An accomplice of cancer immune escape

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