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Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928 · cited 1×
“Cdc42 has been found Cell Lines and Transfectionsto colocalize with Par-3/-6 (Joberty et al., 2000) and LS174T and DLD-1 cells were cultured in RPMI 1640 media con-represents a good candidate effector of LKB1-induced taining standard supplements.”
Background
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“These puncta are found on the dorsal surface of cells, somewhat reminiscent of the results reported earlier with STRAD expression in another epithelial cell line [10,11].”
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“LKB1 is a master serine/threonine kinase that regulates multiple cellular process including growth 26,35 , cell metabolism 20,21 , and cell polarity 36 – 38 .”
Metadata
- Authors
- Baas, A. F., Kuipers, J., van der Wel, N. N., Batlle, E., Koerten, H. K., Peters, P. J., & Clevers, H. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 116
- Issue
- 3
- Pages
- 457-466
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2106302419
- Cited by
- 508
- References
- 2
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3454 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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