Tumor Necrosis Factor

The Bcl2 family: regulators of the cellular life-or-death switch

Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738

IAP proteins: blocking the road to death's door

Salvesen, G. S., & Duckett, C. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm830 · Cited by 1,756

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

Maeda, S., Chang, L., Li, Z.-W., Luo, J.-L., Leffert, H., & Karin, M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00301-7 · Cited by 286

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792

Obesity and cancer: the role of dysfunctional adipose tissue

van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0372 · Cited by 715

The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Chang, L., Kamata, H., Solinas, G., Luo, J.-L., Maeda, S., Venuprasad, K., Liu, Y.-C., & Karin, M. (2006) · Cell · doi:10.1016/j.cell.2006.01.021 · Cited by 706

The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity

Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.051 · Cited by 324

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

Dondelinger, Y., Aguileta, M. A., Goossens, V, Dubuisson, C., Grootjans, S., Dejardin, E., Vandenabeele, P., & Bertrand, M. J. M. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.94 · Cited by 312

Stimulation of Microglial Metabotropic Glutamate Receptor mGlu2 Triggers Tumor Necrosis Factor α-Induced Neurotoxicity in Concert with Microglial-Derived Fas Ligand

Taylor, D. L., Jones, F., Kubota, E. S. F. C. S., & Pocock, J. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4456-04.2005 · Cited by 308

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

Ventura, J.-J., Cogswell, P., Flavell, R. A., Baldwin, A. S., & Davis, R. J. (2004) · Genes & Development · doi:10.1101/gad.1223004 · Cited by 303

Connecting TNF-α Signaling Pathways to iNOS Expression in a Mouse Model of Alzheimer's Disease: Relevance for the Behavioral and Synaptic Deficits Induced by Amyloid β Protein

Medeiros, R., Prediger, R. D. S., Passos, G. F., Pandolfo, P., Duarte, F. S., Franco, J. L., Dafre, A. L., Di Giunta, G., Figueiredo, C. P., Takahashi, R. N., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5047-06.2007 · Cited by 292

Autocrine activation of microglia by tumor necrosis factor-α

Kuno, R., Wang, J., Kawanokuchi, J., Takeuchi, H., Mizuno, T., & Suzumura, A. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.015 · Cited by 232

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

Janelsins, M. C., Mastrangelo, M. A., Park, K. M., Sudol, K. L., Narrow, W. C., Oddo, S., LaFerla, F. M., Callahan, L. M., Federoff, H. J., & Bowers, W. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.080528 · Cited by 220

Tumor Necrosis Factor-α Modulates Survival, Proliferation, and Neuronal Differentiation in Neonatal Subventricular Zone Cell Cultures

Bernardino, L., Agasse, F., Silva, B., Ferreira, R., Grade, S., & Malva, J. O. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0914 · Cited by 220

Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia

Tosun, M., Celik, H., Avci, B., Yavuz, E., Alper, T., & Malatyalioğlu, E. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767051003774942 · Cited by 185

MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease

Saraiva, C., Paiva, J., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.005 · Cited by 169

Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways

Papa, S., Bubici, C., Zazzeroni, F., & Franzoso, G. (2009) · bchm · doi:10.1515/bc.2009.111 · Cited by 156

Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model

Uhlirova, M., Jasper, H., & Bohmann, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504170102 · Cited by 134

Cytotoxicity of TNFα is regulated by integrin‐mediated matrix signaling

Chen, C., Young, J. L., Monzon, R. I., Chen, N., Todorović, V., & Lau, L. F. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601596 · Cited by 143

JNK signaling is the shared pathway linking neuroinflammation, blood-brain barrier disruption and oligodendroglial apoptosis in the white matter injury of the immature brain

Wang, L.-W., Tu, Y.-F., Huang, C.-C., & Ho, C.-J. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-175 · Cited by 119

Necroptosis induced by RIPK3 requires MLKL but not Drp1

Moujalled, D. M., Cook, W. D., Murphy, J. M., & Vaux, D. L. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.18 · Cited by 103

AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain

Costa, B., Siniscalco, D., Trovato, A. E., Comelli, F., Sotgiu, M. L., Colleoni, M., Maione, S., Rossi, F., & Giagnoni, G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706798 · Cited by 99

A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis

Gupta, S., Agrawal, A., Agrawal, S., Su, H., & Gollapudi, S. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-5 · Cited by 77

Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo

Juric, V., Chen, C.-C., & Lau, L. F. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00064-09 · Cited by 70

FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis

Ranjan, K., & Pathak, C. (2016) · Scientific Reports · doi:10.1038/srep22787 · Cited by 53

Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines

Chen, C., & Lau, L. F. (2010) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0080-4 · Cited by 47

The Extracellular Matrix Protein CCN1 Dictates TNFα and FasL Cytotoxicity In Vivo

Chen, C.-C., Juric, V., & Lau, L. F. (2011) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-6612-4_63 · Cited by 8