A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
Open accessAbstract
Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic cells in failure to generate anti-inflammatory responses and directly activating inflammatory responses will be discussed.
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Aging-associated disruptions of PCD regulation and phagocytosis may contribute to aging-associated inflammation, including activation of the NFκB signaling pathway.
“Aging-associated disruptions of PCD regulation and phagocytosis may contribute to aging-associated inflammation, including activation of the NFκB signaling pathway (Gupta et al., 2006; Salvioli et al., 2013), (Shaw et al., 2010).”
From Programmed cell death in aging (2015) · cites this paper as Gupta et al., 2006
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- Authors
- Gupta, S., Agrawal, A., Agrawal, S., Su, H., & Gollapudi, S.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Gupta, Sudhir
- Venue
- Immunity & Ageing
- Published
- 2006-05-19
- Volume
- 3
- Issue
- 1
- Pages
- 5-5
- ISSN
- 1742-4933 (ISSN-L)
- PMC
- PMC1475884
- OpenAlex
- W1823085865
- Cited by
- 77
- References
- 89
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Immunity & Ageing (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG018313)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- immunosenescence, inflammaging, apoptosis, aging, immunodeficiency, inflammation, apoptotic cells, anti-inflammatory response
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